Product References
A gain of function ryanodine receptor 2 mutation (R1760W-RyR2) in catecholaminergic polymorphic ventricular tachycardia.
Clinical and experimental pharmacology & physiology
Li S,Lv T,Yang J,Li K,Yang Y,Zhang P
MA3-925 was used in Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot to indicate that R1760W-RyR2 mutation induced calcium leak, representing a gain of function.
Sun Jan 01 00:00:00 EST 2023
Alterations in cytoskeletal and Ca2+ cycling regulators in atria lacking the obscurin Ig58/59 module.
Frontiers in cardiovascular medicine
Grogan A,Huang W,Brong A,Kane MA,Kontrogianni-Konstantopoulos A
MA3-925 was used in Western Blotting to implicate obscurin, particularly the Ig58/59 module, as an essential regulator of the Z-disk associated cytoskeleton and Ca2+ cycling in the atria.
Tue Jun 13 00:00:00 EDT 2023
Muscle calcium stress cleaves junctophilin1, unleashing a gene regulatory program predicted to correct glucose dysregulation.
eLife
Tammineni ER,Figueroa L,Manno C,Varma D,Kraeva N,Ibarra CA,Klip A,Riazi S,Rios E
MA3-925 was used in Immunohistochemistry-immunofluorescence to demonstrate that a JPh44-like construct induces transcriptional changes predictive of increased glucose utilization in myoblasts, including less transcription and translation of GSK3β and decreased transcription of proteins that reduce utilization of glucose.
Wed Feb 01 00:00:00 EST 2023
Muscle calcium stress cleaves junctophilin1, unleashing a gene regulatory program predicted to correct glucose dysregulation.
eLife
Tammineni ER,Figueroa L,Manno C,Varma D,Kraeva N,Ibarra CA,Klip A,Riazi S,Rios E
MA3-925 was used in Immunohistochemistry-immunofluorescence to demonstrate that a JPh44-like construct induces transcriptional changes predictive of increased glucose utilization in myoblasts, including less transcription and translation of GSK3β and decreased transcription of proteins that reduce utilization of glucose.
Wed Feb 01 00:00:00 EST 2023
Defective excitation-contraction coupling and mitochondrial respiration precede mitochondrial Ca2+ accumulation in spinobulbar muscular atrophy skeletal muscle.
Nature communications
Marchioretti C,Zanetti G,Pirazzini M,Gherardi G,Nogara L,Andreotti R,Martini P,Marcucci L,Canato M,Nath SR,Zuccaro E,Chivet M,Mammucari C,Pacifici M,Raffaello A,Rizzuto R,Mattarei A,Desbats MA,Salviati L,Megighian A,Sorarù G,Pegoraro E,Belluzzi E,Pozzuoli A,Biz C,Ruggieri P,Romualdi C,Lieberman AP,Babu GJ,Sandri M,Blaauw B,Basso M,Pennuto M
MA3-925 was used in Western Blotting to show that excitation-contraction coupling (ECC) deregulation and defective mitochondrial respiration are early but reversible events followed by altered muscle force, calcium dyshomeostasis, and dismantling of triad structure.
Mon Feb 06 00:00:00 EST 2023
Ryanodine receptor RyR1-mediated elevation of Ca2+ concentration is required for the late stage of myogenic differentiation and fusion.
Journal of animal science and biotechnology
Qiu K,Wang Y,Xu D,He L,Zhang X,Yan E,Wang L,Yin J
MA3-925 was used in Immunocytochemistry to explore the role of RyR1 in myogenic differentiation, myotube formation as well as the potential mechanism of RyR1-related myopathies, using RyR1-knockdown myoblasts and CRISPR/Cas9-based RyR1-knockout myoblasts.
Fri Feb 11 00:00:00 EST 2022
Septin7 is indispensable for proper skeletal muscle architecture and function.
eLife
Gönczi M,Ráduly Z,Szabó L,Fodor J,Telek A,Dobrosi N,Balogh N,Szentesi P,Kis G,Antal M,Trencsenyi G,Dienes B,Csernoch L
MA3-925 was used in Immunocytochemistry-immunoflourescence to provide evidence that Septin-7 is essential in proper muscle development, in myotube differentiation and demonstrate its contribution to muscle regeneration.
Fri Aug 05 00:00:00 EDT 2022
Impaired fatigue resistance, sarcoplasmic reticulum function, and mitochondrial activity in soleus muscle of db/db mice.
Physiological reports
Yamamoto H,Eshima H,Kakehi S,Kawamori R,Watada H,Tamura Y
MA3-925 was used in Western Blotting to suggest that fatigue resistance in slow-twitch dominant muscle is impaired in mice with T2DM.
Thu Sep 01 00:00:00 EDT 2022
Quantification of the calcium signaling deficit in muscles devoid of triadin.
PloS one
Manno C,Tammineni E,Figueroa L,Marty I,Ríos E
MA3-925 was used in Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot to find higher resting cytosolic and lower SR-luminal [Ca2+], 40% lower calsequestrin expression, and more CaV1.1, RyR1 and SERCA1.
Wed Mar 09 00:00:00 EST 2022
Region-specific distribution of transversal-axial tubule system organization underlies heterogeneity of calcium dynamics in the right atrium.
American journal of physiology. Heart and circulatory physiology
Lang D,Medvedev RY,Ratajczyk L,Zheng J,Yuan X,Lim E,Han OY,Valdivia HH,Glukhov AV
MA3-925 was used in Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot to indicate different roles of TATS in Ca2+ signaling at distinct anatomical regions of the atria and provide mechanistic insight into pathological atrial remodeling.
Tue Feb 01 00:00:00 EST 2022
Ca2+ release via InsP3Rs enhances RyR recruitment during Ca2+ transients by increasing dyadic [Ca2+] in cardiomyocytes.
Journal of cell science
Demydenko K,Sipido KR,Roderick HL
MA3-925 was used in Immunocytochemistry to propose that this mechanism contributes to neurohormonal modulation of cardiac function.
Thu Jul 15 00:00:00 EDT 2021
CaMKII inhibition reduces arrhythmogenic Ca2+ events in subendocardial cryoinjured rat living myocardial slices.
The Journal of general physiology
Dries E,Bardi I,Nunez-Toldra R,Meijlink B,Terracciano CM
MA3-925 was used in Western Blotting to show arrhythmogenic Ca2+ events in rat myocardial slices are reduced by CaMKII inhibition.
Mon Jun 07 00:00:00 EDT 2021
Essential Role of Somatic Kv2 Channels in High-Frequency Firing in Cartwheel Cells of the Dorsal Cochlear Nucleus.
eNeuro
Irie T
MA3-925 was used in Immunocytochemistry to reveal that Kv2.1 and Kv2.2 were largely present on the cartwheel cell body membrane but not on the axon initial segment (AIS) nor the proximal dendrite.
Fri Jul 02 00:00:00 EDT 2021
β2-Adrenergic agonist salbutamol augments hypertrophy in MHCIIa fibers and sprint mean power output but not muscle force during 11 weeks of resistance training in young men.
Journal of applied physiology (Bethesda, Md. : 1985)
Jessen S,Reitelseder S,Kalsen A,Kreiberg M,Onslev J,Gad A,Ørtenblad N,Backer V,Holm L,Bangsbo J,Hostrup M
MA3-925 was used in Western Blot to suggest that salbutamol is a muscle anabolic drug, which induces greater sprint mean power output, without affecting peak power output and muscle strength when ingested during a period of resistance training.
Mon Mar 01 00:00:00 EST 2021
A chronic high-fat diet exacerbates contractile dysfunction with impaired intracellular Ca2+ release capacity in the skeletal muscle of aged mice.
Journal of applied physiology (Bethesda, Md. : 1985)
Eshima H,Tamura Y,Kakehi S,Kakigi R,Hashimoto R,Funai K,Kawamori R,Watada H
MA3-925 was used in Western Blotting to investigate skeletal muscle contractile function ex vivo and intracellular Ca2+ release in male C57BL/6J mice fed a low-fat diet (LFD) or a high-fat diet (HFD) for 4 or 20 mo.
Fri May 01 00:00:00 EDT 2020
Calsequestrins New Calcium Store Markers of Adult Zebrafish Cerebellum and Optic Tectum.
Frontiers in neuroanatomy
Furlan S,Campione M,Murgia M,Mosole S,Argenton F,Volpe P,Nori A
MA3-925 was used in Immunohistochemistry to identify new endoplasmic reticulum (ER) calcium store markers in zebrafish adult brain with emphasis on cerebellum and optic tectum.
Mon Sep 28 00:00:00 EDT 2020
MG53 suppresses interferon-β and inflammation via regulation of ryanodine receptor-mediated intracellular calcium signaling.
Nature communications
Sermersheim M,Kenney AD,Lin PH,McMichael TM,Cai C,Gumpper K,Adesanya TMA,Li H,Zhou X,Park KH,Yount JS,Ma J
MA3-925 was used in Western Blotting to show human macrophages express MG53, and MG53 protein expression is reduced following virus infection.
Fri Jul 17 00:00:00 EDT 2020
Muscarinic-dependent phosphorylation of the cardiac ryanodine receptor by protein kinase G is mediated by PI3K-AKT-nNOS signaling.
The Journal of biological chemistry
Baine S,Thomas J,Bonilla I,Ivanova M,Belevych A,Li J,Veeraraghavan R,Radwanski PB,Carnes C,Gyorke S
MA3-925 was used in Western Blotting to provide detailed insights into muscarinic-induced PKG signaling and the mediators that regulate cardiac RyR2 phosphorylation critical for cardiovascular function.
Fri Aug 14 00:00:00 EDT 2020
Role of type 2A phosphatase regulatory subunit B56α in regulating cardiac responses to β-adrenergic stimulation in vivo.
Cardiovascular research
Puhl SL,Weeks KL,Güran A,Ranieri A,Boknik P,Kirchhefer U,Müller FU,Avkiran M
MA3-925 was used in Western Blotting to study the role of B56α on cardiac responses to Β-adrenergic receptor stimulation.
Fri Mar 01 00:00:00 EST 2019
SERCA2a tyrosine nitration coincides with impairments in maximal SERCA activity in left ventricles from tafazzin-deficient mice.
Physiological reports
Braun JL,Hamstra SI,Messner HN,Fajardo VA
MA3-925 was used in Western Blotting to demonstrate that sarco/endoplasmic reticulum Ca2+ -ATPase function is impaired in left ventricles obtained from young and old Taz knockdown mice likely due to elevated reactive oxygen/nitrogen species production.
Thu Aug 01 00:00:00 EDT 2019
A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice.
eLife
Dai W,Laforest B,Tyan L,Shen KM,Nadadur RD,Alvarado FJ,Mazurek SR,Lazarevic S,Gadek M,Wang Y,Li Y,Valdivia HH,Shen L,Broman MT,Moskowitz IP,Weber CR
MA3-925 was used in Western Blotting to establish a calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice.
Thu Mar 21 00:00:00 EDT 2019
Cardiac hypertrophy and arrhythmia in mice induced by a mutation in ryanodine receptor 2.
JCI insight
Alvarado FJ,Bos JM,Yuchi Z,Valdivia CR,Hernández JJ,Zhao YT,Henderlong DS,Chen Y,Booher TR,Marcou CA,Van Petegem F,Ackerman MJ,Valdivia HH
MA3-925 was used in Western Blotting to determine the role of RyR2-P1124L in the stimulation of functional and structural alterations in isolated RyR2 channels and open hearts.
Tue Mar 05 00:00:00 EST 2019
Facilitation of ischaemia-induced ventricular fibrillation by catecholamines is mediated by β1 and β2 agonism in the rat heart in vitro.
British journal of pharmacology
Wilder CDE,Pavlaki N,Dursun T,Gyimah P,Caldwell-Dunn E,Ranieri A,Lewis HR,Curtis MJ
MA3-925 was used in Western Blotting to study whether Β-blockers inhibit the ability of catecholamines to facilitate ischaemia-induced ventricular fibrillation.
Tue May 01 00:00:00 EDT 2018
Identification of VAPA and VAPB as Kv2 Channel-Interacting Proteins Defining Endoplasmic Reticulum-Plasma Membrane Junctions in Mammalian Brain Neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Kirmiz M,Vierra NC,Palacio S,Trimmer JS
MA3-925 was used in Immunohistochemistry to suggests that Kv2.1 expression in the PM can affect ER-PM junctions via its phosphorylation-dependent association to ER-localized VAPA and VAPB.
Wed Aug 29 00:00:00 EDT 2018
Sorcin ablation plus β-adrenergic stimulation generate an arrhythmogenic substrate in mouse ventricular myocytes.
Journal of molecular and cellular cardiology
Chen X,Weber C,Farrell ET,Alvarado FJ,Zhao YT,Gómez AM,Valdivia HH
MA3-925 was used in Western Blotting to investigate sorcin's influence on cardiac excitation-contraction coupling and its role in the development of cardiac malfunctions.
Mon Jan 01 00:00:00 EST 2018
Inositol trisphosphate receptor-mediated Ca2+ signalling stimulates mitochondrial function and gene expression in core myopathy patients.
Human molecular genetics
Suman M,Sharpe JA,Bentham RB,Kotiadis VN,Menegollo M,Pignataro V,Molgó J,Muntoni F,Duchen MR,Pegoraro E,Szabadkai G
MA3-925 was used in Western Blotting to indicate that remodelling of skeletal muscle Ca2+ signalling following loss of functional ryanodine receptor mediates bioenergetic adaptation.
Sun Jul 01 00:00:00 EDT 2018
Development of the excitation-contraction coupling machinery and its relation to myofibrillogenesis in human iPSC-derived skeletal myocytes.
Skeletal muscle
Lainé J,Skoglund G,Fournier E,Tabti N
MA3-925 was used in Immunocytochemistry-immunoflourescence to study the development of the excitation-contraction coupling machinery and its relation to myofibrillogenesis in human iPSC-derived skeletal myocytes.
Fri Jan 05 00:00:00 EST 2018
Arrhythmias precede cardiomyopathy and remodeling of Ca2+ handling proteins in a novel model of long QT syndrome.
Journal of molecular and cellular cardiology
Montnach J,Chizelle FF,Belbachir N,Castro C,Li L,Loussouarn G,Toumaniantz G,Carcouët A,Meinzinger AJ,Shmerling D,Benitah JP,Gómez AM,Charpentier F,Baró I
MA3-925 was used in Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot to show that the Scn5a+/ΔQKP mouse model recapitulates the clinical phenotype of mutation carriers and provides new and unexpected insights into the pathological development of the disease in patients carrying the QKP1507-1509 deletion.
Mon Oct 01 00:00:00 EDT 2018
Electrical Stimulation Prevents Preferential Skeletal Muscle Myosin Loss in Steroid-Denervation Rats.
Frontiers in physiology
Yamada T,Himori K,Tatebayashi D,Yamada R,Ashida Y,Imai T,Akatsuka M,Masuda Y,Kanzaki K,Watanabe D,Wada M,Westerblad H,Lanner JT
MA3-925 was used in Western Blotting to demonstrate that electrical stimulation treatment is an effective way to prevent muscle impairments associated with loss of myosin.
Wed Sep 30 00:00:00 EDT 2020
Double-Nanodomain Coupling of Calcium Channels, Ryanodine Receptors, and BK Channels Controls the Generation of Burst Firing.
Neuron
Irie T,Trussell LO
MA3-925 was used in Immunohistochemistry-immunofluorescence to study the ionic currents that control the duration and probability of high frequency action potential bursts in neural computations.
Wed Nov 15 00:00:00 EST 2017
The Arrhythmogenic Calmodulin p.Phe142Leu Mutation Impairs C-domain Ca2+ Binding but Not Calmodulin-dependent Inhibition of the Cardiac Ryanodine Receptor.
The Journal of biological chemistry
Søndergaard MT,Liu Y,Larsen KT,Nani A,Tian X,Holt C,Wang R,Wimmer R,Van Petegem F,Fill M,Chen SR,Overgaard MT
MA3925 was used in western blot to study the ryanodine receptor inhibitory action of the calmodulin p.Phe142Leu mutation
Fri Jan 27 00:00:00 EST 2017
Chronic hypoxia attenuates the vasodilator efficacy of protein kinase G in fetal and adult ovine cerebral arteries.
American journal of physiology. Heart and circulatory physiology
Thorpe RB,Hubbell MC,Silpanisong J,Williams JM,Pearce WJ
MA3-925 was used in Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot to demonstrate hypoxic changes in BK subunit abundances in fetal cerebral arteries and also introduce the use of advanced methods of confocal colocalization to study interaction between PKG and its targets.
Sat Jul 01 00:00:00 EDT 2017
Deregulated Ca2+ cycling underlies the development of arrhythmia and heart disease due to mutant obscurin.
Science advances
Hu LR,Ackermann MA,Hecker PA,Prosser BL,King B,O'Connell KA,Grogan A,Meyer LC,Berndsen CE,Wright NT,Jonathan Lederer W,Kontrogianni-Konstantopoulos A
MA3-925 was used in Immunofluorescence to postulate that enhanced binding between mutant obscurins and phospholamban leads to SERCA2 disinhibition, which may underlie the observed pathological alterations.
Thu Jun 01 00:00:00 EDT 2017
Deregulated Ca2+ cycling underlies the development of arrhythmia and heart disease due to mutant obscurin.
Science advances
Hu LR,Ackermann MA,Hecker PA,Prosser BL,King B,O'Connell KA,Grogan A,Meyer LC,Berndsen CE,Wright NT,Jonathan Lederer W,Kontrogianni-Konstantopoulos A
MA3-925 was used in Immunofluorescence to postulate that enhanced binding between mutant obscurins and phospholamban leads to SERCA2 disinhibition, which may underlie the observed pathological alterations.
Thu Jun 01 00:00:00 EDT 2017
Calcium dysregulation, functional calpainopathy, and endoplasmic reticulum stress in sporadic inclusion body myositis.
Acta neuropathologica communications
Amici DR,Pinal-Fernandez I,Mázala DA,Lloyd TE,Corse AM,Christopher-Stine L,Mammen AL,Chin ER
MA3925 was used in western blot to determine the role of calcium regulation in sporadic inclusion body myositis
Wed Mar 22 00:00:00 EDT 2017
A chemical chaperone improves muscle function in mice with a RyR1 mutation.
Nature communications
Lee CS,Hanna AD,Wang H,Dagnino-Acosta A,Joshi AD,Knoblauch M,Xia Y,Georgiou DK,Xu J,Long C,Amano H,Reynolds C,Dong K,Martin JC,Lagor WR,Rodney GG,Sahin E,Sewry C,Hamilton SL
MA3925 was used in immunohistochemistry and western blot to elucidate the mechanism by which the I4895T mutation in the type 1 ryanodine receptor/Ca(2+) release channel results in disease
Fri Mar 24 00:00:00 EDT 2017
Calcium/calmodulin-dependent kinase II and nitric oxide synthase 1-dependent modulation of ryanodine receptors during β-adrenergic stimulation is restricted to the dyadic cleft.
The Journal of physiology
Dries E,Santiago DJ,Johnson DM,Gilbert G,Holemans P,Korte SM,Roderick HL,Sipido KR
MA3-925 was used in immunocytochemistry to characterize modulation of ryanodine receptors during beta-adrenergic stimulation and restriction to the dyadic cleft via nictric oxide synthase-1 and calcium/calmodulin-dependent kinase II
Sat Oct 15 00:00:00 EDT 2016
LRRC10 is required to maintain cardiac function in response to pressure overload.
American journal of physiology. Heart and circulatory physiology
Brody MJ,Feng L,Grimes AC,Hacker TA,Olson TM,Kamp TJ,Balijepalli RC,Lee Y
MA3-925 was used in immunohistochemistry - paraffin section to investigate LRRC10 and its role in cardiac function under pressure
Fri Jan 15 00:00:00 EST 2016
Early oxidative damage induced by doxorubicin: Source of production, protection by GKT137831 and effect on Ca(2+) transporters in HL-1 cardiomyocytes.
Archives of biochemistry and biophysics
Asensio-López MC,Soler F,Sánchez-Más J,Pascual-Figal D,Fernández-Belda F,Lax A
MA3-925 was used in western blot to characterize induction by doxorubicin causing early oxidative damage and the source of production, effect of Ca(2+) transporters in HL-1 cardiomyocytes and protection by GKT137831
Tue Mar 15 00:00:00 EDT 2016
Role of SERCA and the sarcoplasmic reticulum calcium content on calcium waves propagation in rat ventricular myocytes.
Archives of biochemistry and biophysics
Salazar-Cantú A,Pérez-Treviño P,Montalvo-Parra D,Balderas-Villalobos J,Gómez-Víquez NL,García N,Altamirano J
MA3-925 was used in western blot to characterize calcium waves propagation in rat ventricular myocytes by the role of SERCA and the sarcoplasmic reticulum calcium content
Mon Aug 15 00:00:00 EDT 2016
Calsequestrins in skeletal and cardiac muscle from adult Danio rerio.
Journal of muscle research and cell motility
Furlan S,Mosole S,Murgia M,Nagaraj N,Argenton F,Volpe P,Nori A
MA3-925 was used in immunohistochemistry - frozen section to analyze Danio rerio for calsequestrins in cardiac and skeletal muscle
Fri Apr 01 00:00:00 EDT 2016
The Cytoplasmic Region of Inner Helix S6 Is an Important Determinant of Cardiac Ryanodine Receptor Channel Gating.
The Journal of biological chemistry
Sun B,Guo W,Tian X,Yao J,Zhang L,Wang R,Chen SR
MA3925 was used in western blot to investigate the role of the S6 cytoplasmic region in the function of cardiac ryanodine receptor
Fri Dec 09 00:00:00 EST 2016
Enhanced Cytosolic Ca2+ Activation Underlies a Common Defect of Central Domain Cardiac Ryanodine Receptor Mutations Linked to Arrhythmias.
The Journal of biological chemistry
Xiao Z,Guo W,Sun B,Hunt DJ,Wei J,Liu Y,Wang Y,Wang R,Jones PP,Back TG,Chen SRW
MA3925 was used in western blot to clarify the role of ryanodine receptor mutation in channel function
Fri Nov 18 00:00:00 EST 2016
Sensing Cardiac Electrical Activity With a Cardiac Myocyte--Targeted Optogenetic Voltage Indicator.
Circulation research
Chang Liao ML,de Boer TP,Mutoh H,Raad N,Richter C,Wagner E,Downie BR,Unsöld B,Arooj I,Streckfuss-Bömeke K,Döker S,Luther S,Guan K,Wagner S,Lehnart SE,Maier LS,Stühmer W,Wettwer E,van Veen T,Morlock MM,Knöpfel T,Zimmermann WH
MA3-925 was used in Immunocytochemistry-immunoflourescence to develop a novel, transgenic voltage-sensor model and provide proof of concept for its use in optogenetic sensing of physiological and pathological excitation in cardiac myocytes.
Fri Aug 14 00:00:00 EDT 2015
Phospholamban overexpression in mice causes a centronuclear myopathy-like phenotype.
Disease models & mechanisms
Fajardo VA,Bombardier E,McMillan E,Tran K,Wadsworth BJ,Gamu D,Hopf A,Vigna C,Smith IC,Bellissimo C,Michel RN,Tarnopolsky MA,Quadrilatero J,Tupling AR
MA3-925 was used in western blot to study SERCA dysfunction in mice overexpressing phospholamban
Sat Aug 01 00:00:00 EDT 2015
Epigenetic changes as a common trigger of muscle weakness in congenital myopathies.
Human molecular genetics
Rokach O,Sekulic-Jablanovic M,Voermans N,Wilmshurst J,Pillay K,Heytens L,Zhou H,Muntoni F,Gautel M,Nevo Y,Mitrani-Rosenbaum S,Attali R,Finotti A,Gambari R,Mosca B,Jungbluth H,Zorzato F,Treves S
MA3-925 was used in western blot to determine the mechanisms that reduce ryanodine receptor 1 in patients with congenital myopathies.
Sat Aug 15 00:00:00 EDT 2015
Mitsugumin 56 (hedgehog acyltransferase-like) is a sarcoplasmic reticulum-resident protein essential for postnatal muscle maturation.
FEBS letters
Van B,Nishi M,Komazaki S,Ichimura A,Kakizawa S,Nakanaga K,Aoki J,Park KH,Ma J,Ueyama T,Ogata T,Maruyama N,Takeshima H
MA3-925 was used in western blot to investigate Mitsugumin 56 in skeletal muscle maturation using knockout mice
Tue Apr 28 00:00:00 EDT 2015
Compound RYR1 heterozygosity resulting in a complex phenotype of malignant hyperthermia susceptibility and a core myopathy.
Neuromuscular disorders : NMD
Kraeva N,Heytens L,Jungbluth H,Treves S,Voermans N,Kamsteeg E,Ceuterick-de Groote C,Baets J,Riazi S
MA3-925 was used in western blot to determine which RYR1 variants contribute to malignant hyperthermia
Wed Jul 01 00:00:00 EDT 2015
Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function.
Nature communications
Sharma P,Abbasi C,Lazic S,Teng ACT,Wang D,Dubois N,Ignatchenko V,Wong V,Liu J,Araki T,Tiburcy M,Ackerley C,Zimmermann WH,Hamilton R,Sun Y,Liu PP,Keller G,Stagljar I,Scott IC,Kislinger T,Gramolini AO
MA3-925 was used in western blot to investigate the impact of Tmem65 on heart development
Fri Sep 25 00:00:00 EDT 2015
The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias.
Nature medicine
Chen W,Wang R,Chen B,Zhong X,Kong H,Bai Y,Zhou Q,Xie C,Zhang J,Guo A,Tian X,Jones PP,O'Mara ML,Liu Y,Mi T,Zhang L,Bolstad J,Semeniuk L,Cheng H,Zhang J,Chen J,Tieleman DP,Gillis AM,Duff HJ,Fill M,Song LS,Chen SR
MA3-925 was used in western blot to study the role of the ryanodine receptor store-sensing gate in ventricular tachyarrhythmias
Sat Feb 01 00:00:00 EST 2014
Nuclear BK channels regulate gene expression via the control of nuclear calcium signaling.
Nature neuroscience
Li B,Jie W,Huang L,Wei P,Li S,Luo Z,Friedman AK,Meredith AL,Han MH,Zhu XH,Gao TM
MA3-925 was used in western blot to determine how nuclear calcium signaling controls nuclear BK channels that regulate gene expression
Fri Aug 01 00:00:00 EDT 2014
Suppression of InsP3 receptor-mediated Ca2+ signaling alleviates mutant presenilin-linked familial Alzheimer's disease pathogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Shilling D,Müller M,Takano H,Mak DO,Abel T,Coulter DA,Foskett JK
MA3-925 was used in western blot to study the role of exagerated Ca(2+) signaling mediated by InsP3 receptor1 in the pathogenesis of mutant presenilin-linked Alzheimer's disease
Wed May 14 00:00:00 EDT 2014
Bcl-2 binds to and inhibits ryanodine receptors.
Journal of cell science
Vervliet T,Decrock E,Molgó J,Sorrentino V,Missiaen L,Leybaert L,De Smedt H,Kasri NN,Parys JB,Bultynck G
MA3-925 was used in immunoprecipitation and western blot to study the inhibition of ryanodine recptors by Bcl-2
Sun Jun 15 00:00:00 EDT 2014
Distinct regions of triadin are required for targeting and retention at the junctional domain of the sarcoplasmic reticulum.
The Biochemical journal
Rossi D,Bencini C,Maritati M,Benini F,Lorenzini S,Pierantozzi E,Scarcella AM,Paolini C,Protasi F,Sorrentino V
MA3-925 was used in immunocytochemistry to study three regions of triadin that are involved in its targeting to the sarcoplasmic reticulum junctional domain
Sat Mar 01 00:00:00 EST 2014
The role of ryanodine receptor type 3 in a mouse model of Alzheimer disease.
Channels (Austin, Tex.)
Liu J,Supnet C,Sun S,Zhang H,Good L,Popugaeva E,Bezprozvanny I
MA3-925 was used in western blot to assess the importance of RyanR type 3 in Alzheimer disease pathology
Tue Jun 16 00:00:00 EDT 2015
A unique ion channel clustering domain on the axon initial segment of mammalian neurons.
The Journal of comparative neurology
King AN,Manning CF,Trimmer JS
MA3-925 was used in immunohistochemistry - free floating to study Kv2.1 function and membrane excitability in the axon initial segment
Fri Aug 01 00:00:00 EDT 2014
Establishment of a human skeletal muscle-derived cell line: biochemical, cellular and electrophysiological characterization.
The Biochemical journal
Rokach O,Ullrich ND,Rausch M,Mouly V,Zhou H,Muntoni F,Zorzato F,Treves S
MA3-925 was used in Immunocytochemistry-immunoflourescence to characterize the excitation-contraction coupling machinery of an immortalized human skeletal muscle cell line.
Tue Oct 15 00:00:00 EDT 2013
Novel excitation-contraction uncoupled RYR1 mutations in patients with central core disease.
Neuromuscular disorders : NMD
Kraeva N,Zvaritch E,Rossi AE,Goonasekera SA,Zaid H,Frodis W,Kraev A,Dirksen RT,Maclennan DH,Riazi S
MA3-925 was used in western blot to functionally characterize 5 novel mutations of RYR1 from patients with central core disease
Fri Feb 01 00:00:00 EST 2013
In vivo imaging of intracellular Ca2+ after muscle contractions and direct Ca2+ injection in rat skeletal muscle in diabetes.
American journal of physiology. Regulatory, integrative and comparative physiology
Eshima H,Tanaka Y,Sonobe T,Inagaki T,Nakajima T,Poole DC,Kano Y
MA3-925 was used in western blot to study Ca(2+) handling in diabetic rat skeletal muscle using in vivo imaging
Sun Sep 15 00:00:00 EDT 2013
Decreased cardiac L-type Ca²⁺ channel activity induces hypertrophy and heart failure in mice.
The Journal of clinical investigation
Goonasekera SA,Hammer K,Auger-Messier M,Bodi I,Chen X,Zhang H,Reiken S,Elrod JW,Correll RN,York AJ,Sargent MA,Hofmann F,Moosmang S,Marks AR,Houser SR,Bers DM,Molkentin JD
MA3-925 was used in western blot to study the effect of cardiac L-type calcium channel inhibitors on cardiomyocytes and vasculature
Sun Jan 01 00:00:00 EST 2012
Tirapazamine-doxorubicin interaction referring to heart oxidative stress and Ca²⁺ balance protein levels.
Oxidative medicine and cellular longevity
Sliwinska J,Dudka J,Korga A,Burdan F,Matysiak W,Jodlowska-Jedrych B,Mandziuk S,Dawidek-Pietryka K
MA3-925 was used in western blot to study the effect of tirapazamine on oxidative stress and heart contractile protein level in doxorubicin-treated rats
Tue Sep 04 00:00:00 EDT 2012
Abnormalities of calcium handling proteins in skeletal muscle mirror those of the heart in humans with heart failure: a shared mechanism?
Journal of cardiac failure
Middlekauff HR,Vigna C,Verity MA,Fonarow GC,Horwich TB,Hamilton MA,Shieh P,Tupling AR
MA3-925 was used in western blot to investigate the abnormalities of calcium handling proteins in skeletal and heart muscle during heart failure
Sat Sep 01 00:00:00 EDT 2012
SRP-35, a newly identified protein of the skeletal muscle sarcoplasmic reticulum, is a retinol dehydrogenase.
The Biochemical journal
Treves S,Thurnheer R,Mosca B,Vukcevic M,Bergamelli L,Voltan R,Oberhauser V,Ronjat M,Csernoch L,Szentesi P,Zorzato F
MA3-925 was used in western blot to study the role of a newly identified retinol dehydrogenase in skeletal muscle sarcoplasmic reticulum
Sun Jan 15 00:00:00 EST 2012
Overexpression of histidine-rich calcium binding protein in equine ventricular myocardium.
Veterinary journal (London, England : 1997)
Sacchetto R,Sharova E,Patruno M,Maccatrozzo L,Damiani E,Mascarello F
MA3-925 was used in immunohistochemistry to investigate myocardic histidine-rich calcium binding protein in horses
Sun Jul 01 00:00:00 EDT 2012
Identification of ATP-binding regions in the RyR1 Ca²⁺ release channel.
PloS one
Popova OB,Baker MR,Tran TP,Le T,Serysheva II
MA3-925 was used in western blot to use a photo-activated ATP analogue to identify the regions of the RyR1 receptor that bind ATP
Thu May 09 00:00:00 EDT 2013
Ryanodine receptor oxidation causes intracellular calcium leak and muscle weakness in aging.
Cell metabolism
Andersson DC,Betzenhauser MJ,Reiken S,Meli AC,Umanskaya A,Xie W,Shiomi T,Zalk R,Lacampagne A,Marks AR
MA3-925 was used in western blot to determine the role of Ryanodine receptors in age-related loss of muscle functioning
Wed Aug 03 00:00:00 EDT 2011
Discrepant electrophysiological characteristics and calcium homeostasis of left atrial anterior and posterior myocytes.
Basic research in cardiology
Suenari K,Chen YC,Kao YH,Cheng CC,Lin YK,Chen YJ,Chen SA
MA3-925 was used in western blot to investigate the difference between anterior and posterior myocytes in the left atrium
Sat Jan 01 00:00:00 EST 2011
Nitrosative stress elicited by nNOSµ delocalization inhibits muscle force in dystrophin-null mice.
The Journal of pathology
Li D,Yue Y,Lai Y,Hakim CH,Duan D
MA3-925 was used in western blot to investigate the influence of nNOSmu distribution on the modulation of muscle force
Sat Jan 01 00:00:00 EST 2011
Ageing, but not yet senescent, rats exhibit reduced muscle quality and sarcoplasmic reticulum function.
Acta physiologica (Oxford, England)
Russ DW,Grandy JS,Toma K,Ward CW
MA3-925 was used in western blot to study the effects of ageing on muscle quality and sarcoplasmic reticulum Ca(2+) release.
Tue Mar 01 00:00:00 EST 2011
Extracellular matrix of collagen modulates intracellular calcium handling and electrophysiological characteristics of HL-1 cardiomyocytes with activation of angiotensin II type 1 receptor.
Journal of cardiac failure
Lu YY,Chen YC,Kao YH,Wu TJ,Chen SA,Chen YJ
MA3-925 was used in western blot to investigate the involvement of collagen in calcium homeostasis and the electrophysiological features of cardiomyocytes
Sat Jan 01 00:00:00 EST 2011
Integrity of the network sarcoplasmic reticulum in skeletal muscle requires small ankyrin 1.
Journal of cell science
Ackermann MA,Ziman AP,Strong J,Zhang Y,Hartford AK,Ward CW,Randall WR,Kontrogianni-Konstantopoulos A,Bloch RJ
MA3-925 was used in western blot to investigate the role of small ankyrin 1 in sarcoplasmic reticulum of skeletal muscle
Tue Nov 01 00:00:00 EDT 2011
Antioxidant network expression abrogates oxidative posttranslational modifications in mice.
American journal of physiology. Heart and circulatory physiology
Mital R,Zhang W,Cai M,Huttinger ZM,Goodman LA,Wheeler DG,Ziolo MT,Dwyer KM,d'Apice AJ,Zweier JL,He G,Cowan PJ,Gumina RJ
MA3-925 was used in western blot to examine the therapeutic effect of antioxidant enzymes against myocardial ischemia-reperfusion injury
Sun May 01 00:00:00 EDT 2011
Decrease in the density of t-tubular L-type Ca2+ channel currents in failing ventricular myocytes.
American journal of physiology. Heart and circulatory physiology
Horiuchi-Hirose M,Kashihara T,Nakada T,Kurebayashi N,Shimojo H,Shibazaki T,Sheng X,Yano S,Hirose M,Hongo M,Sakurai T,Moriizumi T,Ueda H,Yamada M
MA3-925 was used in western blot to investigate the mechanism for the decrease of the TT LTCC current density in failing ventricular myocytes
Tue Mar 01 00:00:00 EST 2011
Enhanced excitation-coupled Ca(2+) entry induces nuclear translocation of NFAT and contributes to IL-6 release from myotubes from patients with central core disease.
Human molecular genetics
Treves S,Vukcevic M,Jeannet PY,Levano S,Girard T,Urwyler A,Fischer D,Voit T,Jungbluth H,Lillis S,Muntoni F,Quinlivan R,Sarkozy A,Bushby K,Zorzato F
Tue Feb 01 00:00:00 EST 2011
Alterations of excitation-contraction coupling and excitation coupled Ca(2+) entry in human myotubes carrying CAV3 mutations linked to rippling muscle.
Human mutation
Ullrich ND,Fischer D,Kornblum C,Walter MC,Niggli E,Zorzato F,Treves S
MA3-925 was used in immunocytochemistry and western blot to study calcium homeostasis and excitation-contraction coupling in cultured myotubes derived from two patients with Rippling muscle disease
Tue Mar 01 00:00:00 EST 2011
Overexpression of transient receptor potential canonical type 1 (TRPC1) alters both store operated calcium entry and depolarization-evoked calcium signals in C2C12 cells.
Cell calcium
Oláh T,Fodor J,Ruzsnavszky O,Vincze J,Berbey C,Allard B,Csernoch L
MA3-925 was used in western blot to study the role of transient receptor potential canonical type 1 (TRPC1) in skeletal muscle
Wed Jun 01 00:00:00 EDT 2011
Unmasking potential intracellular roles for dysferlin through improved immunolabeling methods.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Roche JA,Ru LW,O'Neill AM,Resneck WG,Lovering RM,Bloch RJ
MA3-925 was used in immunohistochemistry to investigate the localization of dysferlin in skeletal muscle through optimized immunolabeling methods
Tue Nov 01 00:00:00 EDT 2011
Identification of novel ryanodine receptor 1 (RyR1) protein interaction with calcium homeostasis endoplasmic reticulum protein (CHERP).
The Journal of biological chemistry
Ryan T,Sharma P,Ignatchenko A,MacLennan DH,Kislinger T,Gramolini AO
MA3-925 was used in western blot to identify interacting partners of the skeletal muscle receptor, ryanodine receptor 1
Fri May 13 00:00:00 EDT 2011
PI3Ks maintain the structural integrity of T-tubules in cardiac myocytes.
PloS one
Wu CY,Jia Z,Wang W,Ballou LM,Jiang YP,Chen B,Mathias RT,Cohen IS,Song LS,Entcheva E,Lin RZ
MA3-925 was used in immunocytochemistry to investigate the importance of phosphoinositide 3-kinases in the organization and structure of cardiomyocytic T-tubules
Thu Dec 29 00:00:00 EST 2011
iNOS ablation does not improve specific force of the extensor digitorum longus muscle in dystrophin-deficient mdx4cv mice.
PloS one
Li D,Shin JH,Duan D
MA3-925 was used in western blot to investigate the involvement of inducible nitric oxide synthase in force generation in dystrophin-deficient muscle
Thu Dec 01 00:00:00 EST 2011
Subcellular heterogeneity of ryanodine receptor properties in ventricular myocytes with low T-tubule density.
PloS one
Biesmans L,Macquaide N,Heinzel FR,Bito V,Smith GL,Sipido KR
MA3-925 was used in Immunohistochemistry-immunofluorescence to characterise ryanodine receptor functional properties in relation to T-tubule proximity, at baseline and after myocardial infarction.
Fri Feb 17 00:00:00 EST 2012
Catecholaminergic polymorphic ventricular tachycardia is caused by mutation-linked defective conformational regulation of the ryanodine receptor.
Circulation research
Uchinoumi H,Yano M,Suetomi T,Ono M,Xu X,Tateishi H,Oda T,Okuda S,Doi M,Kobayashi S,Yamamoto T,Ikeda Y,Ohkusa T,Ikemoto N,Matsuzaki M
MA3-925 was used in Immunoprecipitation to conclude that a single point mutation within the RyR2 sensitizes the channel to agonists and reduces the threshold of luminal [Ca(2+)] for activation, primarily mediated by defective interdomain interaction within the RyR2.
Fri Apr 30 00:00:00 EDT 2010
Role of presenilins in neuronal calcium homeostasis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Zhang H,Sun S,Herreman A,De Strooper B,Bezprozvanny I
MA3-925 was used in western blot to demonstrate that presenilins play an important role in neuronal ER calcium homeostasis
Wed Jun 23 00:00:00 EDT 2010
Paclitaxel accelerates spontaneous calcium oscillations in cardiomyocytes by interacting with NCS-1 and the InsP3R.
Journal of molecular and cellular cardiology
Zhang K,Heidrich FM,DeGray B,Boehmerle W,Ehrlich BE
MA3-925 was used in western blot to investigate the effect of taxol on calcium signaling and calcium oscillation
Mon Nov 01 00:00:00 EDT 2010
Modulation of Ca(2+) release through ryanodine receptors in vascular smooth muscle by protein kinase Calpha.
Pflugers Archiv : European journal of physiology
Peng H,Yaney GC,Kirber MT
MA3-925 was used in immunoprecipitation to study the role of PKC alpha in ryanodine receptor-mediated calcium release in vascular smooth muscle
Wed Sep 01 00:00:00 EDT 2010
Calsequestrin and junctin immunoreactivity in hexagonally cross-linked tubular arrays myopathy.
Neuromuscular disorders : NMD
Di Blasi C,Blasevich F,Bellafiore E,Mottarelli E,Gibertini S,Zanotti S,Saredi S,Mantegazza R,Morandi L,Mora M
MA3-925 was used in immunohistochemistry to investigate the immunohistochemical features of hexagonally cross-linked tubular arrays myopathy
Sat May 01 00:00:00 EDT 2010
Initiating treadmill training in late middle age offers modest adaptations in Ca2+ handling but enhances oxidative damage in senescent rat skeletal muscle.
American journal of physiology. Regulatory, integrative and comparative physiology
Thomas MM,Vigna C,Betik AC,Tupling AR,Hepple RT
MA3-925 was used in western blot to identify the relationship between calcium handling and muscle senescence during late middle-age training
Sat May 01 00:00:00 EDT 2010
Total beta-adrenoceptor deficiency results in cardiac hypotrophy and negative inotropy.
Physiological research
Lee S,Grafweg S,Schneider T,Jimenez M,Giacobino JP,Ghanem A,Tiemann K,Bloch W,Müller-Ehmsen J,Schwinger RH,Brixius K
MA3-925 was used in western blot to investigate the role of beta adrenoceptor in cardiac strutural and functional integrity
Mon Feb 14 00:00:00 EST 2011
Aerobic exercise training improves skeletal muscle function and Ca2+ handling-related protein expression in sympathetic hyperactivity-induced heart failure.
Journal of applied physiology (Bethesda, Md. : 1985)
Bueno CR,Ferreira JC,Pereira MG,Bacurau AV,Brum PC
MA3-925 was used in western blot to investigate the effect of aerobic exercise on skeletal muscle function and calcium-related protein expression
Wed Sep 01 00:00:00 EDT 2010
Ca2+ overload and sarcoplasmic reticulum instability in tric-a null skeletal muscle.
The Journal of biological chemistry
Zhao X,Yamazaki D,Park KH,Komazaki S,Tjondrokoesoemo A,Nishi M,Lin P,Hirata Y,Brotto M,Takeshima H,Ma J
MA3-925 was used in western blot to investigate the function of trimeric intracellular cation channels in sarcoplasmic reticulum
Fri Nov 26 00:00:00 EST 2010
Aerobic exercise training improves Ca2+ handling and redox status of skeletal muscle in mice.
Experimental biology and medicine (Maywood, N.J.)
Ferreira JC,Bacurau AV,Bueno CR,Cunha TC,Tanaka LY,Jardim MA,Ramires PR,Brum PC
MA3-925 was used in western blot to investigate the effect of aerobic exercise on calcium signal and redox state of skeletal muscle
Thu Apr 01 00:00:00 EDT 2010
Abnormalities in intracellular Ca2+ regulation contribute to the pathomechanism of Tako-Tsubo cardiomyopathy.
European heart journal
Nef HM,Möllmann H,Troidl C,Kostin S,Voss S,Hilpert P,Behrens CB,Rolf A,Rixe J,Weber M,Hamm CW,Elsässer A
MA3-925 was used in western blot to investigate the gene expression of calcium-handling proteins in Tako-Tsubo cardiomyopathy
Tue Sep 01 00:00:00 EDT 2009
Distribution of ryanodine receptors in rat ventricular myocytes.
Journal of muscle research and cell motility
Salnikov V,Lukyanenko YO,Lederer WJ,Lukyanenko V
MA3-925 was used in immunocytochemistry to investigate the expression of ryanodine receptors in ventricular myocytes
Mon Nov 02 00:00:00 EST 2009
Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Chen X,Tang TS,Tu H,Nelson O,Pook M,Hammer R,Nukina N,Bezprozvanny I
MA3-925 was used in western blot to investigate the association of mutant ATX3 with the type 1 inositol 1,4,5-trisphosphate receptor and its effect on calcium signalling in spinocerebellar ataxia type 3.
Wed Nov 26 00:00:00 EST 2008
IP3 receptor-dependent Ca2+ release modulates excitation-contraction coupling in rabbit ventricular myocytes.
American journal of physiology. Heart and circulatory physiology
Domeier TL,Zima AV,Maxwell JT,Huke S,Mignery GA,Blatter LA
MA3-925 was used in Western Blotting to suggest that in rabbit ventricular myocytes IP(3)R-dependent Ca(2+) release has positive inotropic effects on ECC by facilitating Ca(2+) release through ryanodine receptor clusters.
Fri Feb 01 00:00:00 EST 2008
Reduced expression of sarcalumenin and related Ca2+ -regulatory proteins in aged rat skeletal muscle.
Experimental gerontology
O'Connell K,Gannon J,Doran P,Ohlendieck K
MA3-925 was used in western blot to investigate the expression of sarcalumenin and related calcium-regulatory proteins in rodent skeletal muscle during aging
Wed Oct 01 00:00:00 EDT 2008
Anatomical and neurochemical characterization of dopaminergic interplexiform processes in mouse and rat retinas.
The Journal of comparative neurology
Witkovsky P,Gábriel R,Krizaj D
MA3-925 was used in immunocytochemistry to study the organization of dopaminergic interplexiform processes in the outer layer of rodent retinas and possible corresponding functions
Wed Sep 10 00:00:00 EDT 2008
S100A1 decreases calcium spark frequency and alters their spatial characteristics in permeabilized adult ventricular cardiomyocytes.
Cell calcium
Völkers M,Loughrey CM,Macquaide N,Remppis A,DeGeorge BR,Wegner FV,Friedrich O,Fink RH,Koch WJ,Smith GL,Most P
MA3-925 was used in immunoprecipitation and western blot to suggest that S100A1 is an inhibitory modulator of RyR2 function at diastolic calcium concentrations in rabbit ventricular cardiomyocytes
Thu Feb 01 00:00:00 EST 2007
Nitric oxide regulates growth cone filopodial dynamics via ryanodine receptor-mediated calcium release.
The European journal of neuroscience
Welshhans K,Rehder V
MA3-925 was used in immunocytochemistry to study the role of the ryanodine receptor in the regulation of growth cone filopodial dynamics by nitric oxide
Sat Sep 01 00:00:00 EDT 2007
Disruption of the intracellular Ca2+ homeostasis in the cardiac excitation-contraction coupling is a crucial mechanism of arrhythmic toxicity in aconitine-induced cardiomyocytes.
Biochemical and biophysical research communications
Fu M,Wu M,Wang JF,Qiao YJ,Wang Z
MA3-925 was used in western blot to investigate the mechanism of arrhythmic cytotoxicity in heart cells treated with aconitine
Fri Mar 23 00:00:00 EDT 2007
Increased sarcoplasmic reticulum calcium leak but unaltered contractility by acute CaMKII overexpression in isolated rabbit cardiac myocytes.
Circulation research
Kohlhaas M,Zhang T,Seidler T,Zibrova D,Dybkova N,Steen A,Wagner S,Chen L,Brown JH,Bers DM,Maier LS
MA3-925 was used in immunoprecipitation to study the role of acute CaMKII overexpression in calcium leakage and contractility in rabbit cardiomyocytes
Fri Feb 03 00:00:00 EST 2006
Ca2+/Calmodulin-dependent protein kinase II phosphorylation of ryanodine receptor does affect calcium sparks in mouse ventricular myocytes.
Circulation research
Guo T,Zhang T,Mestril R,Bers DM
MA3-925 was used in Immunoprecipitation to conclude that CaMKII-dependent phosphorylation of RyR by endogenous associated CaMKII increases resting SR Ca2+ release or leak.
Fri Aug 18 00:00:00 EDT 2006
Effects of congestive heart failure on Ca2+ handling in skeletal muscle during fatigue.
Circulation research
Lunde PK,Sejersted OM,Thorud HM,Tønnessen T,Henriksen UL,Christensen G,Westerblad H,Bruton J
MA3-925 was used in Western Blotting to examine the mechanisms causing soleus fibres in rats with congestive heart failure to fatigue more rapidly than in healthy rats.
Fri Jun 23 00:00:00 EDT 2006
Functional uncoupling between Ca2+ release and afterhyperpolarization in mutant hippocampal neurons lacking junctophilins.
Proceedings of the National Academy of Sciences of the United States of America
Moriguchi S,Nishi M,Komazaki S,Sakagami H,Miyazaki T,Masumiya H,Saito SY,Watanabe M,Kondo H,Yawo H,Fukunaga K,Takeshima H
MA3-925 was used in western blot to investigate the important role of junctophilins in neural excitability and plasticity
Tue Jul 11 00:00:00 EDT 2006
Tumor necrosis factor potentiates central vagal afferent signaling by modulating ryanodine channels.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Rogers RC,Van Meter MJ,Hermann GE
MA3-925 was used in immunohistochemistry to investigate the role of the tumor necrosis factor during the central vagal afferent signaling process.
Wed Dec 06 00:00:00 EST 2006
IL-4 inhibits calcium transients in bovine trachealis cells by a ryanodine receptor-dependent mechanism.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Ethier MF,Madison JM
MA3-925 was used in western blot to study how IL-4 inhibits calcium transients in bovine trachealis cells
Sun Jan 01 00:00:00 EST 2006
Increased phospholamban phosphorylation limits the force-frequency response in the MLP-/- mouse with heart failure.
Journal of molecular and cellular cardiology
Antoons G,Vangheluwe P,Volders PG,Bito V,Holemans P,Ceci M,Wuytack F,Caroni P,Mubagwa K,Sipido KR
MA3-925 was used in western blot to study the role of increased phospholamban phosphorylation in limiting the force-frequency response in a model of dilated cardiomyopathy
Wed Mar 01 00:00:00 EST 2006
Further study on the role of HSP70 on Ca2+ homeostasis in rat ventricular myocytes subjected to simulated ischemia.
American journal of physiology. Cell physiology
Liu J,Kam KW,Borchert GH,Kravtsov GM,Ballard HJ,Wong TM
MA3-925 was used in western blot to investigate the role of HSP70 on calcium homeostasis in rat ventricular myocytes subjected to simulated ischemia
Wed Feb 01 00:00:00 EST 2006
Calcium release from ryanodine receptors in the nucleoplasmic reticulum.
Cell calcium
Marius P,Guerra MT,Nathanson MH,Ehrlich BE,Leite MF
MA3-925 was used in western blot to investigate the presence of RyR in the intranuclear extensions of nuclear envelope and its role in calcium signaling
Sun Jan 01 00:00:00 EST 2006
Ca2+ sparks and waves in canine purkinje cells: a triple layered system of Ca2+ activation.
Circulation research
Stuyvers BD,Dun W,Matkovich S,Sorrentino V,Boyden PA,ter Keurs HE
MA3-925 was used in immunocytochemistry to study the role of Ca2+ sparks and waves in canine Purkinje cells
Fri Jul 08 00:00:00 EDT 2005
The origin of tubular aggregates in human myopathies.
The Journal of pathology
Chevessier F,Bauché-Godard S,Leroy JP,Koenig J,Paturneau-Jouas M,Eymard B,Hantaï D,Verdière-Sahuqué M
MA3-925 was used in immunohistochemistry to study the origin and significance of tubular aggregates in human myopathies
Tue Nov 01 00:00:00 EST 2005
Expression of the skeletal muscle dystrophin-dystroglycan complex and syntrophin-nitric oxide synthase complex is severely affected in the type 2 diabetic Goto-Kakizaki rat.
European journal of cell biology
Mulvey C,Harno E,Keenan A,Ohlendieck K
MA3-925 was used in western blot to study the reduced expression of the dystrophin-dystroglycan complex and the syntrophin-NOS complex in skeletal muscle of type 2 diabetic rats and the significance for insulin resistance
Tue Nov 01 00:00:00 EST 2005
S100A1 increases the gain of excitation-contraction coupling in isolated rabbit ventricular cardiomyocytes.
Journal of molecular and cellular cardiology
Kettlewell S,Most P,Currie S,Koch WJ,Smith GL
MA3-925 was used in immunoprecipitation to investigate the effect of s100A1 on the excitation-contraction coupling in isolated rabbit ventricular cardiomyocytes
Thu Dec 01 00:00:00 EST 2005
Neuregulin receptor ErbB2 localization at T-tubule in cardiac and skeletal muscle.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Ueda H,Oikawa A,Nakamura A,Terasawa F,Kawagishi K,Moriizumi T
MA3-925 was used in immunohistochemistry to locate neuregulin receptor ErbB2 at T-tubule in cardiac and skeletal muscle
Sat Jan 01 00:00:00 EST 2005
Effects of ryanodine receptor activation on neurotransmitter release and neuronal cell death following kainic acid-induced status epilepticus.
Epilepsy research
Mori F,Okada M,Tomiyama M,Kaneko S,Wakabayashi K
MA3-925 was used in immunohistochemistry to investigate the molecular mechanism responsible for kainic acid-induced neuronal cell death
Wed Jun 01 00:00:00 EDT 2005
Organic cation permeation through the channel formed by polycystin-2.
The Journal of biological chemistry
Anyatonwu GI,Ehrlich BE
MA3-925 was used in western blot to characterize the channels formed by a member of the transient receptor potential family of ion channels polycystin-2.
Fri Aug 19 00:00:00 EDT 2005
Mechanical unloading improves intracellular Ca2+ regulation in rats with doxorubicin-induced cardiomyopathy.
Journal of the American College of Cardiology
Takaseya T,Ishimatsu M,Tayama E,Nishi A,Akasu T,Aoyagi S
MA3-925 was used in western blot to investigate the effects of mechanical unloading on cardiomyocytes from doxorubicin-induced cardiomyopathy
Tue Dec 07 00:00:00 EST 2004
Cardiac adenoviral S100A1 gene delivery rescues failing myocardium.
The Journal of clinical investigation
Most P,Pleger ST,Völkers M,Heidt B,Boerries M,Weichenhan D,Löffler E,Janssen PM,Eckhart AD,Martini J,Williams ML,Katus HA,Remppis A,Koch WJ
MA3-925 was used in western blot to investigaet the ability of S100A2 gene transfer to rescue failing myocardium
Wed Dec 01 00:00:00 EST 2004
TRPC3 channels confer cellular memory of recent neuromuscular activity.
Proceedings of the National Academy of Sciences of the United States of America
Rosenberg P,Hawkins A,Stiber J,Shelton JM,Hutcheson K,Bassel-Duby R,Shin DM,Yan Z,Williams RS
MA3-925 was used in western blot to study the regulation of NFAT functions through neuromuscular stimulation in rodent skeletal muscles.
Tue Jun 22 00:00:00 EDT 2004
Location of divergent region 2 on the three-dimensional structure of cardiac muscle ryanodine receptor/calcium release channel.
Journal of molecular biology
Liu Z,Zhang J,Wang R,Wayne Chen SR,Wagenknecht T
MA3-925 was used in western blot to study the 3-dimensional localisation of divergent region 2 of the cardiac muscle ryanodine receptor/calcium release channel
Fri Apr 30 00:00:00 EDT 2004
Inhibition of ryanodine receptor 1 in fast skeletal muscle fibers induces a fast-to-slow muscle fiber type transition.
Journal of cell science
Jordan T,Jiang H,Li H,DiMario JX
MA3-925 was used in immunocytochemistry to demonstrate the effect of ryanodine receptor 1 on muscle fiber type specification.
Wed Dec 01 00:00:00 EST 2004
The 12 kDa FK506-binding protein, FKBP12, modulates the Ca(2+)-flux properties of the type-3 ryanodine receptor.
Journal of cell science
Van Acker K,Bultynck G,Rossi D,Sorrentino V,Boens N,Missiaen L,De Smedt H,Parys JB,Callewaert G
MA3-925 was used in western blot to study the effect of FKBP12 on the activity of the type-3 ryanodine receptor.
Mon Mar 01 00:00:00 EST 2004
RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets.
The Journal of biological chemistry
Johnson JD,Han Z,Otani K,Ye H,Zhang Y,Wu H,Horikawa Y,Misler S,Bell GI,Polonsky KS
MA3-925 was used in immunocytochemistry to investigate the role of RyR2 in beta-cell survival in vitro and its mechanism .
Fri Jun 04 00:00:00 EDT 2004
Defects in ryanodine receptor calcium release in skeletal muscle from post-myocardial infarct rats.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Ward CW,Reiken S,Marks AR,Marty I,Vassort G,Lacampagne A
MA3-925 was used in western blot to investigate the relationship between ryanodine receptor calcium release and impaired myocardial function
Fri Aug 01 00:00:00 EDT 2003
S-glutathionylation decreases Mg2+ inhibition and S-nitrosylation enhances Ca2+ activation of RyR1 channels.
The Journal of biological chemistry
Aracena P,Sánchez G,Donoso P,Hamilton SL,Hidalgo C
MA3-925 was used in western blot to investigate the effect of S-glutathionylation and S-nitrosylation on the modulation of RyR1 channels by Mg2+ and calcium.
Fri Oct 31 00:00:00 EST 2003
Activation of metabotropic glutamate receptor mGlu5 on nuclear membranes mediates intranuclear Ca2+ changes in heterologous cell types and neurons.
The Journal of biological chemistry
O'Malley KL,Jong YJ,Gonchar Y,Burkhalter A,Romano C
MA3-925 was used in immunocytochemistry to suggest a role for metabotropic glutamate receptor mGlu5 in intranuclear calcium signaling pathways.
Fri Jul 25 00:00:00 EDT 2003
Transgenic overexpression of the Ca2+-binding protein S100A1 in the heart leads to increased in vivo myocardial contractile performance.
The Journal of biological chemistry
Most P,Remppis A,Pleger ST,Löffler E,Ehlermann P,Bernotat J,Kleuss C,Heierhorst J,Ruiz P,Witt H,Karczewski P,Mao L,Rockman HA,Duncan SJ,Katus HA,Koch WJ
MA3-925 was used in western blot to investigate the role of S100A1 in the regulation of cardiac function in vivo
Fri Sep 05 00:00:00 EDT 2003
Protein kinase A phosphorylation of the ryanodine receptor does not affect calcium sparks in mouse ventricular myocytes.
Circulation research
Li Y,Kranias EG,Mignery GA,Bers DM
MA3-925 was used in immunoprecipitation to study the RyR phosphorylation in PLB-KO mouse ventricular myocytes
Fri Feb 22 00:00:00 EST 2002
Cardiac remodeling and atrial fibrillation in transgenic mice overexpressing junctin.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Hong CS,Cho MC,Kwak YG,Song CH,Lee YH,Lim JS,Kwon YK,Chae SW,Kim DH
MA3-925 was used in western blot to study junctin's functions in heart
Thu Aug 01 00:00:00 EDT 2002
Defective intracellular Ca(2+) signaling contributes to cardiomyopathy in Type 1 diabetic rats.
American journal of physiology. Heart and circulatory physiology
Choi KM,Zhong Y,Hoit BD,Grupp IL,Hahn H,Dilly KW,Guatimosim S,Lederer WJ,Matlib MA
MA3-925 was used in western blot to study the possible contribution of defects in intracellular calcium signaling cardiomyopathy in streptozotocin-induced diabetic rats
Tue Oct 01 00:00:00 EDT 2002
Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).
The Journal of biological chemistry
Xiao B,Masumiya H,Jiang D,Wang R,Sei Y,Zhang L,Murayama T,Ogawa Y,Lai FA,Wagenknecht T,Chen SR
MA3-925 was used in western blot to investigate the function of three ryanodine receptor isoforms during the formation of the functional heteromeric channels.
Fri Nov 01 00:00:00 EST 2002
Contraction and intracellular Ca(2+) handling in isolated skeletal muscle of rats with congestive heart failure.
Circulation research
Lunde PK,Dahlstedt AJ,Bruton JD,Lännergren J,Thorén P,Sejersted OM,Westerblad H
MA3-925 was used in western blot to study the contraction and intracellular calcium handling in rat skeletal muscle
Fri Jun 22 00:00:00 EDT 2001
Three-dimensional reconstruction of the recombinant type 3 ryanodine receptor and localization of its amino terminus.
Proceedings of the National Academy of Sciences of the United States of America
Liu Z,Zhang J,Sharma MR,Li P,Chen SR,Wagenknecht T
MA3-925 was used in western blot to investigate the Three-dimensional structure of the recombinant type 3 ryanodine receptor
Tue May 22 00:00:00 EDT 2001
cADP-ribose/ryanodine channel/Ca2+-release signal transduction pathway in mesangial cells.
American journal of physiology. Renal physiology
Yusufi AN,Cheng J,Thompson MA,Dousa TP,Warner GM,Walker HJ,Grande JP
MA3-925 was used in western blot to demonstrate that MC possess elements of a novel ADP-ribosyl cyclase signaling pathway regulated by proinflammatory cytokines and steroid superfamily hormones.
Sun Jul 01 00:00:00 EDT 2001
Molecular basis of Ca(2)+ activation of the mouse cardiac Ca(2)+ release channel (ryanodine receptor).
The Journal of general physiology
Li P,Chen SR
MA3-925 was used in western blot to study the mechanism for calcium activation of the mouse cardiac ryanodine receptor.
Sun Jul 01 00:00:00 EDT 2001
Dynamic localization and clustering of dendritic Kv2.1 voltage-dependent potassium channels in developing hippocampal neurons.
Neuroscience
Antonucci DE,Lim ST,Vassanelli S,Trimmer JS
MA3-925 was used in immunocytochemistry to study the distribution of Kv2.1 channels in developing rat hippocampal neurons
Wed Feb 20 00:00:00 EST 2002
Activation and propagation of Ca(2+) release during excitation-contraction coupling in atrial myocytes.
Biophysical journal
Kockskämper J,Sheehan KA,Bare DJ,Lipsius SL,Mignery GA,Blatter LA
MA3-925 was used in Immunocytochemistry to study excitation-contraction coupling in cat atrial myocytes which lack transverse tubules and contain both subsarcolemmal junctional and central nonjunctional sarcoplasmic reticulum.
Thu Nov 01 00:00:00 EST 2001
Effects of cardioplegic arrest and reperfusion on rabbit cardiac ryanodine receptors.
Japanese circulation journal
Ikeda Y,Gohra H,Hamano K,Zempo N,Ueyama T,Ohkusa T,Matsuzaki M,Esato K
MA3-925 was used in Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot to investigate cardioplegic arrest and reperfusion on ryanodine receptors.
Sun Apr 01 00:00:00 EST 2001
Restoration of diastolic function in senescent rat hearts through adenoviral gene transfer of sarcoplasmic reticulum Ca(2+)-ATPase.
Circulation
Schmidt U,del Monte F,Miyamoto MI,Matsui T,Gwathmey JK,Rosenzweig A,Hajjar RJ
MA3-925 was used in western blot to investigate the possible relationship between the restoration of the SR calcium-ATPase through adenoviral gene transfer in the aging heart and the normalization of diastolic function in vivo
Tue Feb 22 00:00:00 EST 2000
Ca2+-induced Ca2+ release supports the relay mode of activity in thalamocortical cells.
Neuron
Budde T,Sieg F,Braunewell KH,Gundelfinger ED,Pape HC
MA3-925 was used in western blot to investigate the mechanism for the calcium-induced calcium release in thalamocortical cells
Mon May 01 00:00:00 EDT 2000
Identification of a 97-kDa mastoparan-binding protein involving in Ca(2+) release from skeletal muscle sarcoplasmic reticulum.
Molecular pharmacology
Hirata Y,Nakahata N,Ohizumi Y
MA3-925 was used in immunoprecipitation to investigate the function of mastoparan in heavy fraction of SR of rabbit skeletal muscles
Thu Jun 01 00:00:00 EDT 2000
Translational diffusion of globular proteins in the cytoplasm of cultured muscle cells.
Biophysical journal
Arrio-Dupont M,Foucault G,Vacher M,Devaux PF,Cribier S
MA3-925 was used in immunocytochemistry to investigate the translational diffusion of globular proteins in the cytoplasm of cultured muscle cells
Tue Feb 01 00:00:00 EST 2000
Long-chain acylcarnitine induces Ca2+ efflux from the sarcoplasmic reticulum.
Journal of cardiovascular pharmacology
Yamada KA,Kanter EM,Newatia A
MA3-925 was used in western blot to investigate the role of long-chain acylcarnitine on caclium efflux from the sarcoplasmic reticulum
Sat Jul 01 00:00:00 EDT 2000
Enhanced sarcoplasmic reticulum Ca(2+) release following intermittent sprint training.
American journal of physiology. Regulatory, integrative and comparative physiology
Ortenblad N,Lunde PK,Levin K,Andersen JL,Pedersen PK
MA3-925 was used in western blot to study how intermittent sprint training affects sarcoplasmic reticulum functions
Sat Jul 01 00:00:00 EDT 2000
Isometric force and endurance in soleus muscle of thyroid hormone receptor-alpha(1)- or -beta-deficient mice.
American journal of physiology. Regulatory, integrative and comparative physiology
Johansson C,Lännergren J,Lunde PK,Vennström B,Thorén P,Westerblad H
MA3-925 was used in western blot to investigate the role of thyroid hormone receptor (TR)-alpha1 and -beta on skeletal muscle function
Wed Mar 01 00:00:00 EST 2000
Nitric oxide synthase in cardiac sarcoplasmic reticulum.
Proceedings of the National Academy of Sciences of the United States of America
Xu KY,Huso DL,Dawson TM,Bredt DS,Becker LC
MA3-925 was used in immunohistochemistry to study the localization and function of the nitric oxide synthase in heart.
Tue Jan 19 00:00:00 EST 1999
Further characterization of the type 3 ryanodine receptor (RyR3) purified from rabbit diaphragm.
The Journal of biological chemistry
Murayama T,Oba T,Katayama E,Oyamada H,Oguchi K,Kobayashi M,Otsuka K,Ogawa Y
MA3-925 was used in western blot to study the structure and function of type 3 ryanodine receptor (RyR3) in rabbit diaphragm
Fri Jun 11 00:00:00 EDT 1999
Skeletal muscle type ryanodine receptor is involved in calcium signaling in human B lymphocytes.
The Journal of biological chemistry
Sei Y,Gallagher KL,Basile AS
MA3-925 was used in western blot to study the role of skeletal muscle type RYR in calcium signaling in human B lymphocytes
Fri Feb 26 00:00:00 EST 1999
Cellular distribution of Ca2+ pumps and Ca2+ release channels in rat cardiac hypertrophy induced by aortic stenosis.
Circulation
Anger M,Lompré AM,Vallot O,Marotte F,Rappaport L,Samuel JL
MA3-925 was used in immunohistochemistry to study the cellular distribution of RyR in rat cardiac hypertrophy
Tue Dec 01 00:00:00 EST 1998
Role of ryanodine receptors in the assembly of calcium release units in skeletal muscle.
The Journal of cell biology
Protasi F,Franzini-Armstrong C,Allen PD
MA3-925 was used in immunohistochemistry to investigate the calcium release apparatus in skeletal muscle
Mon Feb 23 00:00:00 EST 1998
Positioning of major tryptic fragments in the Ca2+ release channel (ryanodine receptor) resulting from partial digestion of rabbit skeletal muscle sarcoplasmic reticulum.
The Journal of biological chemistry
Chen SR,Airey JA,MacLennan DH
MA3-925 was used in western blot to investigate the major tryptic fragments of RyR and their relationships with the insoluble membrane fraction and sedimentation behavior
Mon Oct 25 00:00:00 EDT 1993
