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Product Details
MA1-83782
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Dog,
Human,
Mouse,
Pig,
Rat
Published species
Human,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
G-1
Immunogen
Short synthetic polypeptide corresponding to the C-terminal domain of the ryanodine receptor.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
purified
Storage buffer
PBS
Contains
0.01% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2183056
Product Specific Information
For immunofluorescent applications, visualization by confocal microscopy is required. Detection by standard fluorescent microscopy will not be adequate to detect the RyR. Additionally, fluorescent, and not enzymatic, detection is required. Due to the intensity of confocal lasers, the use of an anti-fading agent such as DABCO is strongly recommended.
Mouse anti Human Ryanodine Receptor antibody, clone RYR-1 recognizes the human ryanodine receptor 1, also known as Skeletal muscle calcium release channel or skeletal muscle ryanodine receptor.
Target Information
Ryanodine receptors have been shown to play critical roles in the intracellular Ca2+ signaling occurring during cell activation in muscle cells and non-muscled cells. Ryanodine receptor, ~500 kDa, can be isolated from a variety of cell types such as lymphocytes, macrophages, granulocytes, fibroblasts, epithelial, endothelial cells, skeletal muscles, cardiac muscle and brain tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: calcium release channel; calcium release channel (ryanodine receptor 1); calcium release channel protein; central core disease of muscle; CRC1, RYR1; halothane; porcine stress syndrome; protein phosphatase 1, regulatory subunit 137; Ryanodine receptor 1; ryanodine receptor 1 (skeletal); ryanodine receptor 1, skeletal muscle; ryanodine receptor 1-like, skeletal muscle; RYR-1; sarcoplasmic reticulum calcium release channel; Skeletal muscle calcium release channel; Skeletal muscle ryanodine receptor; Skeletal muscle-type ryanodine receptor; Type 1 ryanodine receptor; type 1-like ryanodine receptor
Gene Aliases: AI528790; CCO; CRC; MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; RYR1; Ryr1l; SKRR
UniProt ID: (Human) P21817, (Mouse) E9PZQ0
Entrez Gene ID: (Pig) 396718, (Bovine) 100139857, (Human) 6261, (Dog) 606491, (Mouse) 20190, (Rat) 114207
ryanodine-sensitive calcium-release channel activity
voltage-gated calcium channel activity
calcium channel activity
calcium ion binding
calmodulin binding
ATP binding
protease binding
protein binding
calcium-release channel activity
ion channel activity
enzyme binding
ligand-gated ion channel
scaffold/adaptor protein
outflow tract morphogenesis
muscle contraction
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
skin development
ossification involved in bone maturation
skeletal muscle fiber development
protein homotetramerization
calcium ion transmembrane transport
cellular response to calcium ion
cellular response to caffeine
response to hypoxia
calcium ion transport
response to caffeine
ion transmembrane transport
release of sequestered calcium ion into cytosol
regulation of cytosolic calcium ion concentration
regulation of cardiac conduction
transport
ion transport
cellular calcium ion homeostasis
regulation of muscle contraction
multicellular organism development
regulation of ion transmembrane transport
transmembrane transport
sarcoplasmic reticulum calcium ion transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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