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Ryanodine Receptor 1 Antibody (ARR-001-200UL) in IHC (P)
Expression of RyR1 in rat skeletal muscle - Immunohistochemical staining of paraffin embedded sections of ratquadriceps using Anti-Ryanodine Receptor 1 Antibody (#ARR-001), (1:100).RyR1is expressed in fibers of striate muscle. Note that smooth muscle in the arterial walls is negative as well as the surrounding connective tissue.Hematoxilin is used as the counterstain.
Product Details
ARR-001-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)RAENEKDATTEKNKKR, corresponding to amino acid residues 1371-1386 of human RyR1, Intracellular, N-terminus
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).
Target Information
Ryanodine receptors have been shown to play critical roles in the intracellular Ca2+ signaling occurring during cell activation in muscle cells and non-muscled cells. Ryanodine receptor, ~500 kDa, can be isolated from a variety of cell types such as lymphocytes, macrophages, granulocytes, fibroblasts, epithelial, endothelial cells, skeletal muscles, cardiac muscle and brain tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: calcium release channel; central core disease of muscle; protein phosphatase 1, regulatory subunit 137; Ryanodine receptor 1; ryanodine receptor 1 (skeletal); ryanodine receptor 1, skeletal muscle; ryanodine receptor 1-like, skeletal muscle; RYR-1; sarcoplasmic reticulum calcium release channel; Skeletal muscle calcium release channel; Skeletal muscle ryanodine receptor; Skeletal muscle-type ryanodine receptor; Type 1 ryanodine receptor; type 1-like ryanodine receptor
Gene Aliases: AI528790; CCO; MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; RYR1; Ryr1l; SKRR
UniProt ID: (Human) P21817, (Mouse) E9PZQ0
Entrez Gene ID: (Human) 6261, (Mouse) 20190, (Rat) 114207
protease binding
ryanodine-sensitive calcium-release channel activity
voltage-gated calcium channel activity
calcium channel activity
calcium ion binding
protein binding
calmodulin binding
calcium-release channel activity
ion channel activity
enzyme binding
ligand-gated ion channel
scaffold/adaptor protein
response to hypoxia
outflow tract morphogenesis
calcium ion transport
muscle contraction
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
response to caffeine
ion transmembrane transport
skin development
ossification involved in bone maturation
skeletal muscle fiber development
release of sequestered calcium ion into cytosol
regulation of cytosolic calcium ion concentration
cellular response to caffeine
regulation of cardiac conduction
transport
ion transport
cellular calcium ion homeostasis
regulation of muscle contraction
multicellular organism development
regulation of ion transmembrane transport
transmembrane transport
sarcoplasmic reticulum calcium ion transport
calcium ion transmembrane transport
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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