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NeoBiotechnologies
S100A9 + Calprotectin (S100A8/A9 Complex) Recombinant Rabbit Monoclonal Antibody (MAC3157R)
Product Details
6279-RBM5-P1
Product Specifications
Species Reactivity
Baboon,
Bovine,
Dog,
Horse,
Cat,
Guinea pig,
Goat,
Human,
Mouse,
Non-human primate,
Pig,
Rabbit,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
MAC3157R
Immunogen
Affinity Purified monocyte membrane preparation
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4° C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.
Target Information
The S100A8/A9 heterocomplex, also called MRP-8/MRP-14 complex or calprotectin, comprises 60% of the cytoplasmic protein fraction of circulating polymorphonuclear granulocytes and is also found in monocytes, macrophages and ileal tissue eosinophils. Peripheral blood monocytes carry the antigen extra- and intracellularly, neutrophils only intracellularly. The S100A8/A9 complex has antibacterial, antifungal, immunomodulating and antiproliferative effects. Besides this it is a potent chemotactic factor for neutrophils. Plasma concentrations are elevated in diseases associated with increased neutrophil activity, like inflammatory bowel disease. Granulocytes terminate their existence after transmigration through the intestinal wall. Therefore calprotectin is also detectable in feces. Elevated levels of calprotectin have been observed in body fluids such as plasma, saliva, gingival crevicular fluid, stools, and synovial fluid during infection and inflammatory conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AI323541; B8Ag; BEE11; BEE22; calcium binding protein; S100 protein; calgranulin A; calgranulin B; Calgranulin-A; Calgranulin-B; calprotectin; Calprotectin L1H subunit; Calprotectin L1L subunit; CFAG; Chemotactic cytokine CP-10; chemotactic S100 protein; Cystic fibrosis antigen; intracellular calcium-binding protein (MRP14); Leukocyte L1 complex heavy chain; Leukocyte L1 complex light chain; macrophage migration inhibitory factor-related protein-14; macrophage migration inhibitory factor-related protein-8; Migration inhibitory factor-related protein 14; Migration inhibitory factor-related protein 8; MRP-14; MRP-8; Myeloid-related protein 14; Neutrophil cytosolic 23 kDa protein; Neutrophil cytosolic 7 kDa protein; p14; p23; P7; p8; Pro-inflammatory S100 cytokine; Protein S100-A8; Protein S100-A9; S100 calcium binding protein A8; S100 calcium binding protein A8 (calgranulin A); S100 calcium binding protein A9 (calgranulin B); S100 calcium-binding protein A8; S100 calcium-binding protein A8 (calgranulin A); S100 calcium-binding protein A9; S100 calcium-binding protein A9 (calgranulin B); S100A8/S100A9; Urinary stone protein band A
Gene Aliases: 60B8AG; AI323541; AW546964; B8Ag; BEE22; CAGA; CAGB; CFAG; CGLA; CGLB; CP-10; GAGB; L1AG; LIAG; MA387; MAC387; MIF; MRP-14; MRP-8; MRP14; MRP8; NIF; P14; P8; S100A8; S100A9
UniProt ID: (Bovine) P28782, (Human) P05109, (Bovine) P28783, (Rabbit) P50117, (Human) P06702, (Rat) P50115, (Mouse) P27005, (Mouse) P31725, (Rat) P50116
Entrez Gene ID: (Guinea pig) 100735514, (Horse) 100061766, (Dog) 490461, (Bovine) 616818, (Pig) 100127488, (Rabbit) 100008985, (Goat) 102168876, (Human) 6279, (Dog) 490463, (Bovine) 532569, (Pig) 100127489, (Horse) 100061730, (Rabbit) 100008704, (Goat) 102182273, (Human) 6280, (Rat) 116547, (Mouse) 20201, (Mouse) 20202, (Guinea pig) 100735238, (Rat) 94195
leukocyte migration involved in inflammatory response
positive regulation of peptide secretion
autophagy
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
astrocyte development
peptidyl-cysteine S-nitrosylation
neutrophil chemotaxis
innate immune response
positive regulation of inflammatory response
neutrophil aggregation
cellular oxidant detoxification
positive regulation of intrinsic apoptotic signaling pathway
cytokine production
acute inflammatory response
chronic inflammatory response
inflammatory response
response to zinc ion
positive regulation of cell growth
sequestering of zinc ion
response to lipopolysaccharide
chemokine production
wound healing
defense response to bacterium
response to ethanol
defense response to fungus
positive regulation of NF-kappaB transcription factor activity
regulation of cytoskeleton organization
regulation of translation
signal transduction
cell-cell signaling
positive regulation of blood coagulation
actin cytoskeleton reorganization
peptidyl-cysteine S-trans-nitrosylation
regulation of integrin biosynthetic process
immune system process
chemotaxis
regulation of inflammatory response
leukocyte chemotaxis
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