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Product Details
PA5-18717
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sequence (DQSKKGKGKPQN) corresponding to the internal amino acids of Sall4
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_10984858
Product Specific Information
This antibody is predicted to react with mouse based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.
Target Information
Sall4 protein is encoded by the Sall4 gene located on chromosome 20 in humans and belongs to the Spalt-like protein family. It plays an important role in somatic stem cell maintenance and is studied as a stem cell biomarker. It is a zinc finger transcription factor that is upregulated during development and shown to interact with Oct4 and Sox2. It also forms a complex with Nanog to maintain the pluripotency of Embryonic Stem cells (ESCs). Several current research studies focus on its function as an oncogene and tumor biomarker. Some of the reported target genes of Sall4 include p53, Bmi-1, Bcl2 and XIAP.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: dJ1112F19.1; sal-like 4; Sal-like protein 4; spalt-like transcription factor 4; Zinc finger protein SALL4
Gene Aliases: 5730441M18Rik; AA407717; AL022809; AW536104; C330011P20Rik; C78083; C78563; Sall4; Tex20
UniProt ID: (Mouse) Q6S7E9
Entrez Gene ID: (Rat) 686412, (Mouse) 99377
negative regulation of transcription from RNA polymerase II promoter
in utero embryonic development
inner cell mass cell proliferation
neural tube closure
ventricular septum development
heart development
tissue development
stem cell population maintenance
neural tube development
embryonic limb morphogenesis
positive regulation of transcription from RNA polymerase II promoter
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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