Osenses

SCNN1D Polyclonal Antibody

Product Details

OSR00100W-100UL

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

1:300-1:2,000

Miscellaneous PubMed (Misc)

View 5 publications 5 publications

Product Specifications

Species Reactivity

Human

Published species

Not Applicable

Host/Isotype

Rabbit / Ig

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide from the extracellular domain of human amiloride sensitive sodium channel subunit delta (SCNN1D, SCNED, Delta-ENaC) conjugated to an immunogenic carrier protein was used as the antigen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

Conc. Not Determined

Storage buffer

whole serum

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.

Specificity of this antibody: SCNN1D.

Target Information

SNX6 interacts with members of the transforming growth factor-beta family of receptor serine-threonine kinases. These receptors belong to two classes: type II receptors that bind ligand, and type I receptors that are subsequently recruited to transduce the signal. Of the type II receptors, SNX6 was found to interact strongly with ActRIIB and more moderately with wild type and kinase-defective mutants of TbetaRII. Of the type I receptors, SNX6 was found to interact only with inactivated TbetaRI. SNXs 1-4 also interacted with the transforming growth factor-beta receptor family, showing different receptor preferences. Conversely, SNX6 behaved similarly to the other SNX proteins in its interactions with receptor tyrosine kinases. Strong heteromeric interactions were also seen among SNX1, -2, -4, and -6, suggesting the formation in vivo of oligomeric complexes. These findings are the first evidence for the association of the SNX family of molecules with receptor serine-threonine kinases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Cloning and functional expression of a new epithelial sodium channel delta subunit isoform differentially expressed in neurons of the human and monkey telencephalon.

Journal of neurochemistry

Giraldez T,Afonso-Oramas D,Cruz-Muros I,Garcia-Marin V,Pagel P,González-Hernández T,Alvarez de la Rosa D

Wed Aug 01 00:00:00 EDT 2007

The DNA sequence and biological annotation of human chromosome 1.

Nature

Gregory SG,Barlow KF,McLay KE,Kaul R,Swarbreck D,Dunham A,Scott CE,Howe KL,Woodfine K,Spencer CC,Jones MC,Gillson C,Searle S,Zhou Y,Kokocinski F,McDonald L,Evans R,Phillips K,Atkinson A,Cooper R,Jones C,Hall RE,Andrews TD,Lloyd C,Ainscough R,Almeida JP,Ambrose KD,Anderson F,Andrew RW,Ashwell RI,Aubin K,Babbage AK,Bagguley CL,Bailey J,Beasley H,Bethel G,Bird CP,Bray-Allen S,Brown JY,Brown AJ,Buckley D,Burton J,Bye J,Carder C,Chapman JC,Clark SY,Clarke G,Clee C,Cobley V,Collier RE,Corby N,Coville GJ,Davies J,Deadman R,Dunn M,Earthrowl M,Ellington AG,Errington H,Frankish A,Frankland J,French L,Garner P,Garnett J,Gay L,Ghori MR,Gibson R,Gilby LM,Gillett W,Glithero RJ,Grafham DV,Griffiths C,Griffiths-Jones S,Grocock R,Hammond S,Harrison ES,Hart E,Haugen E,Heath PD,Holmes S,Holt K,Howden PJ,Hunt AR,Hunt SE,Hunter G,Isherwood J,James R,Johnson C,Johnson D,Joy A,Kay M,Kershaw JK,Kibukawa M,Kimberley AM,King A,Knights AJ,Lad H,Laird G,Lawlor S,Leongamornlert DA,Lloyd DM,Loveland J,Lovell J,Lush MJ,Lyne R,Martin S,Mashreghi-Mohammadi M,Matthews L,Matthews NS,McLaren S,Milne S,Mistry S,Moore MJ,Nickerson T,O'Dell CN,Oliver K,Palmeiri A,Palmer SA,Parker A,Patel D,Pearce AV,Peck AI,Pelan S,Phelps K,Phillimore BJ,Plumb R,Rajan J,Raymond C,Rouse G,Saenphimmachak C,Sehra HK,Sheridan E,Shownkeen R,Sims S,Skuce CD,Smith M,Steward C,Subramanian S,Sycamore N,Tracey A,Tromans A,Van Helmond Z,Wall M,Wallis JM,White S,Whitehead SL,Wilkinson JE,Willey DL,Williams H,Wilming L,Wray PW,Wu Z,Coulson A,Vaudin M,Sulston JE,Durbin R,Hubbard T,Wooster R,Dunham I,Carter NP,McVean G,Ross MT,Harrow J,Olson MV,Beck S,Rogers J,Bentley DR,Banerjee R,Bryant SP,Burford DC,Burrill WD,Clegg SM,Dhami P,Dovey O,Faulkner LM,Gribble SM,Langford CF,Pandian RD,Porter KM,Prigmore E

Thu May 18 00:00:00 EDT 2006

Delta-subunit confers novel biophysical features to alpha beta gamma-human epithelial sodium channel (ENaC) via a physical interaction.

The Journal of biological chemistry

Ji HL,Su XF,Kedar S,Li J,Barbry P,Smith PR,Matalon S,Benos DJ

Fri Mar 24 00:00:00 EST 2006

Complete sequencing and characterization of 21,243 full-length human cDNAs.

Nature genetics

Ota T,Suzuki Y,Nishikawa T,Otsuki T,Sugiyama T,Irie R,Wakamatsu A,Hayashi K,Sato H,Nagai K,Kimura K,Makita H,Sekine M,Obayashi M,Nishi T,Shibahara T,Tanaka T,Ishii S,Yamamoto J,Saito K,Kawai Y,Isono Y,Nakamura Y,Nagahari K,Murakami K,Yasuda T,Iwayanagi T,Wagatsuma M,Shiratori A,Sudo H,Hosoiri T,Kaku Y,Kodaira H,Kondo H,Sugawara M,Takahashi M,Kanda K,Yokoi T,Furuya T,Kikkawa E,Omura Y,Abe K,Kamihara K,Katsuta N,Sato K,Tanikawa M,Yamazaki M,Ninomiya K,Ishibashi T,Yamashita H,Murakawa K,Fujimori K,Tanai H,Kimata M,Watanabe M,Hiraoka S,Chiba Y,Ishida S,Ono Y,Takiguchi S,Watanabe S,Yosida M,Hotuta T,Kusano J,Kanehori K,Takahashi-Fujii A,Hara H,Tanase TO,Nomura Y,Togiya S,Komai F,Hara R,Takeuchi K,Arita M,Imose N,Musashino K,Yuuki H,Oshima A,Sasaki N,Aotsuka S,Yoshikawa Y,Matsunawa H,Ichihara T,Shiohata N,Sano S,Moriya S,Momiyama H,Satoh N,Takami S,Terashima Y,Suzuki O,Nakagawa S,Senoh A,Mizoguchi H,Goto Y,Shimizu F,Wakebe H,Hishigaki H,Watanabe T,Sugiyama A,Takemoto M,Kawakami B,Yamazaki M,Watanabe K,Kumagai A,Itakura S,Fukuzumi Y,Fujimori Y,Komiyama M,Tashiro H,Tanigami A,Fujiwara T,Ono T,Yamada K,Fujii Y,Ozaki K,Hirao M,Ohmori Y,Kawabata A,Hikiji T,Kobatake N,Inagaki H,Ikema Y,Okamoto S,Okitani R,Kawakami T,Noguchi S,Itoh T,Shigeta K,Senba T,Matsumura K,Nakajima Y,Mizuno T,Morinaga M,Sasaki M,Togashi T,Oyama M,Hata H,Watanabe M,Komatsu T,Mizushima-Sugano J,Satoh T,Shirai Y,Takahashi Y,Nakagawa K,Okumura K,Nagase T,Nomura N,Kikuchi H,Masuho Y,Yamashita R,Nakai K,Yada T,Nakamura Y,Ohara O,Isogai T,Sugano S

Thu Jan 01 00:00:00 EST 2004

Molecular cloning and functional expression of a novel amiloride-sensitive Na+ channel.

The Journal of biological chemistry

Waldmann R,Champigny G,Bassilana F,Voilley N,Lazdunski M

Fri Nov 17 00:00:00 EST 1995

Bioinformatics

Protein Aliases: Amiloride-sensitive sodium channel subunit delta; Delta-ENaC; Delta-NaCH; Epithelial Na(+) channel subunit delta; MGC149710; Nonvoltage-gated sodium channel 1 subunit delta; SCNED; sodium channel, non voltage gated 1 delta subunit; sodium channel, non-voltage-gated 1, delta subunit; sodium channel, nonvoltage-gated 1, delta; sodium channel, voltage-gated, type I, delta polypeptide

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Gene Aliases: DNACH; ENaCd; ENaCdelta; SCNED; SCNN1D

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UniProt ID: (Human) P51172

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Entrez Gene ID: (Human) 6339

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Function(s)

protein binding ligand-gated sodium channel activity ion channel

Process(es)

sodium ion transport ion transmembrane transport sodium ion transmembrane transport response to stimulus sensory perception of taste

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

SCNN1D Polyclonal Antibody

Product Details

OSR00100W-100UL

Immunohistochemistry (IHC)

Miscellaneous PubMed (Misc)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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