Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: CFYRLYQDLE THRLPCTSRC PRPCRESAFK LSTGTSRWPS AKSAGWTLAT LGEQGLPHQS HRQRSSLAKI NIVYQELNYR SVEEAPVYSV PQLLSAMGS
SNX6 interacts with members of the transforming growth factor-beta family of receptor serine-threonine kinases. These receptors belong to two classes: type II receptors that bind ligand, and type I receptors that are subsequently recruited to transduce the signal. Of the type II receptors, SNX6 was found to interact strongly with ActRIIB and more moderately with wild type and kinase-defective mutants of TbetaRII. Of the type I receptors, SNX6 was found to interact only with inactivated TbetaRI. SNXs 1-4 also interacted with the transforming growth factor-beta receptor family, showing different receptor preferences. Conversely, SNX6 behaved similarly to the other SNX proteins in its interactions with receptor tyrosine kinases. Strong heteromeric interactions were also seen among SNX1, -2, -4, and -6, suggesting the formation in vivo of oligomeric complexes. These findings are the first evidence for the association of the SNX family of molecules with receptor serine-threonine kinases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Amiloride-sensitive sodium channel subunit delta; Delta-ENaC; Delta-NaCH; Epithelial Na(+) channel subunit delta; MGC149710; Nonvoltage-gated sodium channel 1 subunit delta; SCNED; sodium channel, non voltage gated 1 delta subunit; sodium channel, non-voltage-gated 1, delta subunit; sodium channel, nonvoltage-gated 1, delta; sodium channel, voltage-gated, type I, delta polypeptide
Gene Aliases: DNACH; ENaCd; ENaCdelta; SCNED; SCNN1D
UniProt ID: (Human) P51172
Entrez Gene ID: (Human) 6339
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support