Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
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Positive Control: K562
Predicted Reactivity: Dog (97%), Pig (91%), Rabbit (89%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (89%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
SELK is a selenoprotein, containing a selenocysteine residue at its active site. SELK is localized to the endoplasmic reticulum and is highly expressed in the heart, where it may function as an antioxidant. SELK can bind to proteins such as the ER-associated degradation (ERAD) components p97 ATPase, Derlin-1 and -2, and SelS as well as proteins in the oligosaccharyltransferase complex, suggesting that SELK may be involved in the Derlin-dependent ERAD of glycosylated misfolded proteins. SELK is also thought to be important in Ca2+ flux in immune cells, and is cleaved by m-calpain in resting macrophages. When these macrophages are activated through different Toll-like receptors, this cleavage is inhibited.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Selenoprotein K; SelK
Gene Aliases: HSPC030; HSPC297; SELENOK; SELK
UniProt ID: (Human) Q9Y6D0
Entrez Gene ID: (Human) 58515
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