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Apoptosis is related to many diseases and development. Mitochondrial proteins, such as cytochrome c, Apaf-1, and AIF play important role in apoptosis. A novel mitochondrial septin-like protein was identified recently and designated ARTS for apoptosis related protein in TGF-beta signaling pathway. ARTS that is encoded by the human septin H5/PNUTL2/CDCrel2b gene is located to mitochondria and translocates to the nucleus when apoptosis occurs. ARTS is expressed in many tissues. It enhances cell death induced by TGF-beta and, to a lesser extent, by other apoptotic agents, such as TNF-a and Fas ligand.
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Protein Aliases: 4-Sep; apoptosis-related protein in the TGF-beta signaling pathway; Bradeion beta; Brain protein H5; CE5B3 beta; Cell division control-related protein 2; cell division control-related protein 2b; cerebral protein 7; expression gene 3 in rat visual cortex; expression gene 3-1 in rat visual cortex; hCDCREL-2; M-Septin; peanut-like 2; peanut-like 2 homolog; Peanut-like protein 2; septin H5; Septin-4; septin-M
Gene Aliases: ARTS; Bh5; BRADEION; C17orf47; CE5B3; EG3-1RVC; EG3RVC; Gm11492; H5; hCDCREL-2; hucep-7; MART; OTTMUSG00000001265; PNUTL2; SEP4; SEPT4; SEPTIN4
UniProt ID: (Human) O43236, (Mouse) P28661
Entrez Gene ID: (Human) 5414, (Mouse) 18952, (Rat) 287606
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