Proteintech

SERPINE2 Polyclonal Antibody

SERPINE2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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SERPINE2 Antibody (11303-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human pancreas cancer using 11303-1-AP (SERPINE2 antibody) at dilution of 1:50 (under 10x lens).

SERPINE2 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

SERPINE2 Antibody in Immunoprecipitation (IP)

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Product Details

11303-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 3 publications 3 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:50

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 3 publications 3 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SERPINE2 Fusion Protein Ag1830 (28-397 aa encoded by BC015663)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.19 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: EELGSNTGI QVFNQIVKSR PHDNIVISPH GIASVLGMLQ LGADGRTKKQ LAMVMRYGVN GVGKILKKIN KAIVSKKNKD IVTVANAVFV KNASEIEVPF VTRNKDVFQC EVRNVNFEDP ASACDSINAW VKNETRDMID NLLSPDLIDG VLTRLVLVNA VYFKGLWKSR FQPENTKKRT FVAADGKSYQ VPMLAQLSVF RCGSTSAPND LWYNFIELPY HGESISMLIA LPTESSTPLS AIIPHISTKT IDSWMSIMVP KRVQVILPKF TAVAQTDLKE PLKVLGITDM FDSSKANFAK ITTGSENLHV SHILQKAKIE VSEDGTKASA ATTAILIARS SPPWFIVDRP FLFFIRHNPT GAVLFMGQIN K (28-397 aa encoded by BC015663)

Target Information

This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

FOXP3+ macrophage represses acute ischemic stroke-induced neural inflammation.

Autophagy

Cai W,Hu M,Li C,Wu R,Lu D,Xie C,Zhang W,Li T,Shen S,Huang H,Qiu W,Liu Q,Lu Y,Lu Z

Sat Apr 01 00:00:00 EDT 2023

SERPINE2/PN-1 regulates the DNA damage response and radioresistance by activating ATM in lung cancer.

Cancer letters

Zhang J,Wu Q,Zhu L,Xie S,Tu L,Yang Y,Wu K,Zhao Y,Wang Y,Xu Y,Chen X,Ma S,Zhang S

Sat Jan 01 00:00:00 EST 2022

SERPINE2/PN-1 regulates the DNA damage response and radioresistance by activating ATM in lung cancer.

Cancer letters

Zhang J,Wu Q,Zhu L,Xie S,Tu L,Yang Y,Wu K,Zhao Y,Wang Y,Xu Y,Chen X,Ma S,Zhang S

Sat Jan 01 00:00:00 EST 2022

SERPINE2/PN-1 regulates the DNA damage response and radioresistance by activating ATM in lung cancer.

Cancer letters

Zhang J,Wu Q,Zhu L,Xie S,Tu L,Yang Y,Wu K,Zhao Y,Wang Y,Xu Y,Chen X,Ma S,Zhang S

Sat Jan 01 00:00:00 EST 2022

High expression level of serpin peptidase inhibitor clade E member 2 is associated with poor prognosis in lung adenocarcinoma.

Respiratory research

Dokuni R,Nagano T,Jimbo N,Sato H,Kiriu T,Yasuda Y,Yamamoto M,Tachihara M,Kobayashi K,Maniwa Y,Nishimura Y

Mon Dec 14 00:00:00 EST 2020

High expression level of serpin peptidase inhibitor clade E member 2 is associated with poor prognosis in lung adenocarcinoma.

Respiratory research

Dokuni R,Nagano T,Jimbo N,Sato H,Kiriu T,Yasuda Y,Yamamoto M,Tachihara M,Kobayashi K,Maniwa Y,Nishimura Y

Mon Dec 14 00:00:00 EST 2020

BAP31 Promotes Tumor Cell Proliferation by Stabilizing SERPINE2 in Hepatocellular Carcinoma.

Frontiers in cell and developmental biology

Zhang X,Jiang D,Yang S,Sun Y,Liu Y,Shi J,Hu C,Pan J,Liu T,Jin B,Yang K

Tue Dec 29 00:00:00 EST 2020

Deep Coverage Tissue and Cellular Proteomics Revealed IL-1β Can Independently Induce the Secretion of TNF-Associated Proteins from Human Synoviocytes.

Journal of immunology (Baltimore, Md. : 1950)

Tang S,Deng S,Guo J,Chen X,Zhang W,Cui Y,Luo Y,Yan Z,He QY,Shen S,Wang T

Mon Jan 15 00:00:00 EST 2018

Deep Coverage Tissue and Cellular Proteomics Revealed IL-1β Can Independently Induce the Secretion of TNF-Associated Proteins from Human Synoviocytes.

Journal of immunology (Baltimore, Md. : 1950)

Tang S,Deng S,Guo J,Chen X,Zhang W,Cui Y,Luo Y,Yan Z,He QY,Shen S,Wang T

Mon Jan 15 00:00:00 EST 2018

Proteomics analysis of site- and stage-specific protein expression after peripheral nerve injury.

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association

Aiki H,Wada T,Iba K,Oki G,Sohma H,Yamashita T,Kokai Y

Thu Nov 01 00:00:00 EDT 2018

Proteomics analysis of site- and stage-specific protein expression after peripheral nerve injury.

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association

Aiki H,Wada T,Iba K,Oki G,Sohma H,Yamashita T,Kokai Y

Thu Nov 01 00:00:00 EDT 2018

Molecular basis of Mitomycin C enhanced corneal sensory nerve repair after debridement wounding.

Scientific reports

Stepp MA,Pal-Ghosh S,Tadvalkar G,Li L,Brooks SR,Morasso MI

Fri Nov 16 00:00:00 EST 2018

Molecular basis of Mitomycin C enhanced corneal sensory nerve repair after debridement wounding.

Scientific reports

Stepp MA,Pal-Ghosh S,Tadvalkar G,Li L,Brooks SR,Morasso MI

Fri Nov 16 00:00:00 EST 2018

Transcriptional profiling of endometriosis tissues identifies genes related to organogenesis defects.

Journal of cellular physiology

Crispi S,Piccolo MT,D'Avino A,Donizetti A,Viceconte R,Spyrou M,Calogero RA,Baldi A,Signorile PG

Sun Sep 01 00:00:00 EDT 2013

Transcriptional profiling of endometriosis tissues identifies genes related to organogenesis defects.

Journal of cellular physiology

Crispi S,Piccolo MT,D'Avino A,Donizetti A,Viceconte R,Spyrou M,Calogero RA,Baldi A,Signorile PG

Sun Sep 01 00:00:00 EDT 2013

Bioinformatics

Protein Aliases: GDN; Glia derived nexin; Glia-derived nexin; Glia-derived nexin/protease nexin I; glial-derived neurite promoting factor; P17; Peptidase inhibitor 7; PI-7; plasminogen activator inhibitor type 1; PN-1; Protease nexin 1; Protease nexin I; protease nexin PN-1; serine (or cysteine) peptidase inhibitor, clade E, member 2; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; serine (or cysteine) proteinase inhibitor, clade E, member 2; serine protease inhibitor 4; Serine protease-inhibitor 4; Serpin E2; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; serpin peptidase inhibitor, clade E, member 2; SERPINE 2

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Gene Aliases: B230326M24Rik; GDN; GDNPF; Gdnpn1; PAI-1; PI-7; PI7; PN-1; PN1; PNI; SERPINE2; Spi4; Spin4

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UniProt ID: (Human) Q5D0C4, (Rat) P07092, (Mouse) Q07235

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Entrez Gene ID: (Human) 5270, (Rat) 29366, (Mouse) 20720

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Function(s)

serine-type endopeptidase inhibitor activity receptor binding protein binding glycosaminoglycan binding heparin binding peptidase inhibitor activity protease inhibitor

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SERPINE2 Polyclonal Antibody

SERPINE2 Antibody (11303-1-AP) in IHC (P)

Product Details

11303-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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