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SERPING1/C1 Inactivator Polyclonal Antibody

SERPING1/C1 Inactivator Antibody in Immunocytochemistry (ICC/IF)

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SERPING1/C1 Inactivator Antibody (12259-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells using 12259-1-AP (SERPING1/C1 Inactivator antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).

SERPING1/C1 Inactivator Antibody in Immunohistochemistry (Paraffin) (IHC (P))

SERPING1/C1 Inactivator Antibody in Western Blot (WB)

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Product Details

12259-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 3 publications 3 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SERPING1/C1 Inactivator Fusion Protein Ag2819 (151-500 aa encoded by BC011171)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.19 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: LKLYHAFSA MKKVETNMAF SPFSIASLLT QVLLGAGENT KTNLESILSY PKDFTCVHQA LKGFTTKGVT SVSQIFHSPD LAIRDTFVNA SRTLYSSSPR VLSNNSDANL ELINTWVAKN TNNKISRLLD SLPSDTRLVL LNAIYLSAKW KTTFDPKKTR MEPFHFKNSV IKVPMMNSKK YPVAHFIDQT LKAKVGQLQL SHNLSLVILV PQNLKHRLED MEQALSPSVF KAIMEKLEMS KFQPTLLTLP RIKVTTSQDM LSIMEKLEFF DFSYDLNLCG LTEDPDLQVS AMQHQTVLEL TETGVEAAAA SAISVARTLL VFEVQQPFLF MLWDQQHKFP VFMGRVYDPR A (151-500 aa encoded by BC011171)

Target Information

This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

β-arrestin1 regulates astrocytic reactivity via Drp1-dependent mitochondrial fission: implications in postoperative delirium.

Journal of neuroinflammation

Hua F,Zhu H,Yu W,Zheng Q,Zhang L,Liang W,Lin Y,Xiao F,Yi P,Xiong Y,Dong Y,Li H,Fang L,Liu H,Ying J,Wang X

Thu May 11 00:00:00 EDT 2023

β-arrestin1 regulates astrocytic reactivity via Drp1-dependent mitochondrial fission: implications in postoperative delirium.

Journal of neuroinflammation

Hua F,Zhu H,Yu W,Zheng Q,Zhang L,Liang W,Lin Y,Xiao F,Yi P,Xiong Y,Dong Y,Li H,Fang L,Liu H,Ying J,Wang X

Thu May 11 00:00:00 EDT 2023

Fluoxetine inhibited the activation of A1 reactive astrocyte in a mouse model of major depressive disorder through astrocytic 5-HT_2BR/β-arrestin2 pathway.

Journal of neuroinflammation

Fang Y,Ding X,Zhang Y,Cai L,Ge Y,Ma K,Xu R,Li S,Song M,Zhu H,Liu J,Ding J,Lu M,Hu G

Sat Jan 29 00:00:00 EST 2022

Integrated Multiomics Analysis Identifies a Novel Biomarker Associated with Prognosis in Intracerebral Hemorrhage.

Oxidative medicine and cellular longevity

Shen Y,Yang W,Xiong X,Li X,Xiao Z,Yu J,Liu F,Gui S,Xie X,Lv F,Zhao L,Hu L,Manaenko A,Xie P,Li Q

Fri Oct 14 00:00:00 EDT 2022

A New Serum Biomarker Set to Detect Mild Cognitive Impairment and Alzheimer's Disease by Peptidome Technology.

Journal of Alzheimer's disease : JAD

Abe K,Shang J,Shi X,Yamashita T,Hishikawa N,Takemoto M,Morihara R,Nakano Y,Ohta Y,Deguchi K,Ikeda M,Ikeda Y,Okamoto K,Shoji M,Takatama M,Kojo M,Kuroda T,Ono K,Kimura N,Matsubara E,Osakada Y,Wakutani Y,Takao Y,Higashi Y,Asada K,Senga T,Lee LJ,Tanaka K

Mon Apr 19 00:00:00 EDT 2021

Knockdown of circulating C1 inhibitor induces neurovascular impairment, glial cell activation, neuroinflammation, and behavioral deficits.

Glia

Farfara D,Feierman E,Richards A,Revenko AS,MacLeod RA,Norris EH,Strickland S

Mon Jul 01 00:00:00 EDT 2019

Chronic Cerebral Hypoperfusion Activates the Coagulation and Complement Cascades in Alzheimer's Disease Mice.

Neuroscience

Shi X,Ohta Y,Liu X,Shang J,Morihara R,Nakano Y,Feng T,Huang Y,Sato K,Takemoto M,Hishikawa N,Yamashita T,Abe K

Sun Sep 15 00:00:00 EDT 2019

Chronic Cerebral Hypoperfusion Activates the Coagulation and Complement Cascades in Alzheimer's Disease Mice.

Neuroscience

Shi X,Ohta Y,Liu X,Shang J,Morihara R,Nakano Y,Feng T,Huang Y,Sato K,Takemoto M,Hishikawa N,Yamashita T,Abe K

Sun Sep 15 00:00:00 EDT 2019

Decreased expression of serine protease inhibitor family G1 (SERPING1) in prostate cancer can help distinguish high-risk prostate cancer and predicts malignant progression.

Urologic oncology

Peng S,Du T,Wu W,Chen X,Lai Y,Zhu D,Wang Q,Ma X,Lin C,Li Z,Guo Z,Huang H

Wed Aug 01 00:00:00 EDT 2018

Decreased expression of serine protease inhibitor family G1 (SERPING1) in prostate cancer can help distinguish high-risk prostate cancer and predicts malignant progression.

Urologic oncology

Peng S,Du T,Wu W,Chen X,Lai Y,Zhu D,Wang Q,Ma X,Lin C,Li Z,Guo Z,Huang H

Wed Aug 01 00:00:00 EDT 2018

The Alzheimer's disease peptide β-amyloid promotes thrombin generation through activation of coagulation factor XII.

Journal of thrombosis and haemostasis : JTH

Zamolodchikov D,Renné T,Strickland S

Sun May 01 00:00:00 EDT 2016

The Alzheimer's disease peptide β-amyloid promotes thrombin generation through activation of coagulation factor XII.

Journal of thrombosis and haemostasis : JTH

Zamolodchikov D,Renné T,Strickland S

Sun May 01 00:00:00 EDT 2016

The Alzheimer's disease peptide β-amyloid promotes thrombin generation through activation of coagulation factor XII: reply.

Journal of thrombosis and haemostasis : JTH

Zamolodchikov D,Strickland S

Fri Jul 01 00:00:00 EDT 2016

The Alzheimer's disease peptide β-amyloid promotes thrombin generation through activation of coagulation factor XII: reply.

Journal of thrombosis and haemostasis : JTH

Zamolodchikov D,Strickland S

Fri Jul 01 00:00:00 EDT 2016

Bioinformatics

Protein Aliases: anti-thrombin 3; antithrombin; Antithrombin-III; ATIII; C1 esterase inhibitor; C1 Inh; C1 inhibitor; C1-inhibiting factor; complement component 1 inhibitor; Plasma protease C1 inhibitor; serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1; serine (or cysteine) proteinase inhibitor, clade G (C1 inhibitor), member 1; serine (or cysteine) proteinase inhibitor, clade G, member 1; serine/cysteine proteinase inhibitor clade G member 1; Serpin C1; Serpin G1; serpin peptidase inhibitor clade C member 1; serpin peptidase inhibitor clade G member 1; serpin peptidase inhibitor, clade C (antithrombin), member 1; serpin peptidase inhibitor, clade C, member 1; serpin peptidase inhibitor, clade G (C1 inhibitor), member 1

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Gene Aliases: AI114908; At-3; AT3; AT3D; ATIII; C1IN; C1INH; C1NH; HAE1; HAE2; PRO0309; SERPINC1; SERPING1; THPH7

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UniProt ID: (Human) P01008, (Human) P05155, (Mouse) P32261, (Mouse) P97290

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Entrez Gene ID: (Human) 462, (Human) 710, (Mouse) 11905, (Mouse) 12258

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Function(s)

protease binding serine-type endopeptidase inhibitor activity protein binding heparin binding peptidase inhibitor activity complement binding protease inhibitor

Process(es)

response to nutrient blood coagulation negative regulation of endopeptidase activity negative regulation of inflammatory response regulation of blood coagulation, intrinsic pathway negative regulation of complement activation, lectin pathway platelet degranulation complement activation, classical pathway aging blood coagulation, intrinsic pathway blood circulation fibrinolysis innate immune response hemostasis negative regulation of peptidase activity immune system process regulation of blood coagulation negative regulation of complement activation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SERPING1/C1 Inactivator Polyclonal Antibody

SERPING1/C1 Inactivator Antibody (12259-1-AP) in ICC/IF

Product Details

12259-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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