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SESN2 Antibody (PA5-120259) in WB
Western blot analysis of SESN2 in extracts of various cell lines. Samples were incubated with SESN2 Polyclonal antibody (Product # PA5-120259) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
PA5-120259
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 211-480 of human SESN2 (NP_113647.1).
Conjugate
Form
Liquid
Concentration
0.63 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2913831
Product Specific Information
Positive test controls include: 293T, U-87MG, HepG2, K-562.
Immunogen sequence: VFGCGILPEG DADGSPAPQA PTPPSEQSSP PSRDPLNNSG GFESARDVEA LMERMQQLQE SLLRDEGTSQ EEMESRFELE KSESLLVTPS ADILEPSPHP DMLCFVEDPT FGYEDFTRRG AQAPPTFRAQ DYTWEDHGYS LIQRLYPEGG QLLDEKFQAA YSLTYNTIAM HSGVDTSVLR RAIWNYIHCV FGIRYDDYDY GEVNQLLERN LKVYIKTVAC YPEKTTRRMY NLFWRHFRHS EKVHVNLLLL EARMQAALLY ALRAITRYMT
Target Information
This gene encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hypoxia induced gene 95; hypoxia-induced; Hypoxia-induced gene; Sestrin-2
Gene Aliases: HI95; SES2; SESN2; SEST2
UniProt ID: (Human) P58004, (Mouse) P58043
Entrez Gene ID: (Human) 83667, (Mouse) 230784
regulation of protein phosphorylation
fatty acid beta-oxidation
autophagy
response to glucose
positive regulation of macroautophagy
negative regulation of cell growth
DNA damage response, signal transduction by p53 class mediator
mitochondrial DNA metabolic process
response to insulin
cellular response to oxidative stress
positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress
protein kinase B signaling
glucose import
triglyceride homeostasis
cellular response to amino acid stimulus
cellular response to leucine
reactive oxygen species metabolic process
regulation of gluconeogenesis involved in cellular glucose homeostasis
cellular oxidant detoxification
positive regulation of protein localization to nucleus
regulation of response to reactive oxygen species
negative regulation of translation in response to endoplasmic reticulum stress
negative regulation of TORC1 signaling
regulation of cAMP-dependent protein kinase activity
mitochondrion organization
glucose homeostasis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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