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Product Details
H00083667-M01
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
1A12
Immunogen
SESN2 (AAH13304.1, 1 a.a. approximately 480 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
Immunogen sequence: MIVADSECRA ELKDYLRFAP GGVGDSGPGE EQRESRARRG PRGPSAFIPV EEVLREGAES LEQHLGLEAL MSSGRVDNLA VVMGLHPDYF TSFWRLHYLL LHTDGPLASS WRHYIAIMAA ARHQCSYLVG SHMAEFLQTG GDPEWLLGLH RAPEKLRKLS EINKLLAHRP WLITKEHIQA LLKTGEHTWS LAELIQALVL LTHCHSLSSF VFGCGILPEG DADGSPAPQA PTPPSEQSSP PSRDPLNNSG GFESARDVEA LMERMQQLQE SLLRDEGTSQ EEMESRFELE KSESLLVTPS ADILEPSPHP DMLCFVEDPT FGYEDFTRRG AQAPPTFRAQ DYTWEDHGYS LIQRLYPEGG QLLDEKFQAA YSLTYNTIAM HSGVDTSVLR RAIWNYIHCV FGIRYDDYDY GEVNQLLERN LKVYIKTVAC YPEKTTRRMY NLFWRHFRHS EKVHVNLLLL EARMQAALLY ALRAITRYMT
Target Information
This gene encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hypoxia induced gene 95; hypoxia-induced; Hypoxia-induced gene; Sestrin-2
Gene Aliases: HI95; SES2; SESN2; SEST2
UniProt ID: (Human) P58004
Entrez Gene ID: (Human) 83667
regulation of protein phosphorylation
fatty acid beta-oxidation
autophagy
response to glucose
positive regulation of macroautophagy
negative regulation of cell growth
DNA damage response, signal transduction by p53 class mediator
mitochondrial DNA metabolic process
response to insulin
cellular response to oxidative stress
positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress
protein kinase B signaling
glucose import
triglyceride homeostasis
cellular response to amino acid stimulus
cellular response to leucine
reactive oxygen species metabolic process
regulation of gluconeogenesis involved in cellular glucose homeostasis
cellular oxidant detoxification
positive regulation of protein localization to nucleus
regulation of response to reactive oxygen species
negative regulation of translation in response to endoplasmic reticulum stress
negative regulation of TORC1 signaling
regulation of cAMP-dependent protein kinase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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