Proteintech

SET Polyclonal Antibody

SET Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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SET Antibody (55201-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded mouse spleen tissue slide using (Product # 55201-1-AP) (SET/TAF-I antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

Product Image Gallery

Product Details

55201-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 7 publications 7 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is specific to SET. It can recognize isoform1 and isoform2 of SET.

Target Information

SET is a multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone binding. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The Effects of Protein Phosphatase 2A Activation with Novel Tricyclic Sulfonamides on Hepatoblastoma.

Journal of pediatric surgery

Bownes LV,Julson JR,Quinn CH,Hutchins SC,Erwin MH,Markert HR,Stewart JE,Mroczek-Musulman E,Aye J,Yoon KJ,Ohlmeyer M,Beierle EA

Thu Jun 01 00:00:00 EDT 2023

Pre-Clinical Study Evaluating Novel Protein Phosphatase 2A Activators as Therapeutics for Neuroblastoma.

Cancers

Bownes LV,Marayati R,Quinn CH,Beierle AM,Hutchins SC,Julson JR,Erwin MH,Stewart JE,Mroczek-Musulman E,Ohlmeyer M,Aye JM,Yoon KJ,Beierle EA

Wed Apr 13 00:00:00 EDT 2022

MicroRNA-1915-3p inhibits cell migration and invasion by targeting SET in non-small-cell lung cancer.

BMC cancer

Pan H,Pan Z,Guo F,Meng F,Zu L,Fan Y,Li Y,Li M,Du X,Zhang X,Shao Y,Wei M,Li X,Zhou Q

Sat Nov 13 00:00:00 EST 2021

MicroRNA-1915-3p inhibits cell migration and invasion by targeting SET in non-small-cell lung cancer.

BMC cancer

Pan H,Pan Z,Guo F,Meng F,Zu L,Fan Y,Li Y,Li M,Du X,Zhang X,Shao Y,Wei M,Li X,Zhou Q

Sat Nov 13 00:00:00 EST 2021

Selective Peptidomimetic Inhibitors of NTMT1/2: Rational Design, Synthesis, Characterization, and Crystallographic Studies.

Journal of medicinal chemistry

Mackie BD,Chen D,Dong G,Dong C,Parker H,Schaner Tooley CE,Noinaj N,Min J,Huang R

Thu Sep 10 00:00:00 EDT 2020

Overexpression of SET oncoprotein is associated with tumor progression and poor prognosis in human gastric cancer.

Oncology reports

Yuan X,Zhang T,Zheng X,Zhang Y,Feng T,Liu P,Sun Z,Qin S,Liu X,Zhang L,Song J,Liu Y

Fri Sep 01 00:00:00 EDT 2017

Overexpression of SET oncoprotein is associated with tumor progression and poor prognosis in human gastric cancer.

Oncology reports

Yuan X,Zhang T,Zheng X,Zhang Y,Feng T,Liu P,Sun Z,Qin S,Liu X,Zhang L,Song J,Liu Y

Fri Sep 01 00:00:00 EDT 2017

Overexpression of PP2A inhibitor SET oncoprotein is associated with tumor progression and poor prognosis in human non-small cell lung cancer.

Oncotarget

Liu H,Gu Y,Wang H,Yin J,Zheng G,Zhang Z,Lu M,Wang C,He Z

Sat Jun 20 00:00:00 EDT 2015

Overexpression of PP2A inhibitor SET oncoprotein is associated with tumor progression and poor prognosis in human non-small cell lung cancer.

Oncotarget

Liu H,Gu Y,Wang H,Yin J,Zheng G,Zhang Z,Lu M,Wang C,He Z

Sat Jun 20 00:00:00 EDT 2015

SET-mediated NDRG1 inhibition is involved in acquisition of epithelial-to-mesenchymal transition phenotype and cisplatin resistance in human lung cancer cell.

Cellular signalling

Liu H,Gu Y,Yin J,Zheng G,Wang C,Zhang Z,Deng M,Liu J,Jia X,He Z

Mon Dec 01 00:00:00 EST 2014

SET-mediated NDRG1 inhibition is involved in acquisition of epithelial-to-mesenchymal transition phenotype and cisplatin resistance in human lung cancer cell.

Cellular signalling

Liu H,Gu Y,Yin J,Zheng G,Wang C,Zhang Z,Deng M,Liu J,Jia X,He Z

Mon Dec 01 00:00:00 EST 2014

Reactivating PP2A by FTY720 as a novel therapy for AML with C-KIT tyrosine kinase domain mutation.

Journal of cellular biochemistry

Yang Y,Huang Q,Lu Y,Li X,Huang S

Sun Apr 01 00:00:00 EDT 2012

Reactivating PP2A by FTY720 as a novel therapy for AML with C-KIT tyrosine kinase domain mutation.

Journal of cellular biochemistry

Yang Y,Huang Q,Lu Y,Li X,Huang S

Sun Apr 01 00:00:00 EDT 2012

Bioinformatics

Protein Aliases: HLA-DR-associated protein II; I IGAAD; I-2PP2A; IGAAD; Inhibitor of granzyme A-activated DNase; inhibitor-2 of protein phosphatase-2A; OTTHUMP00000022286; PHAPII; Phosphatase 2A inhibitor I2PP2A; protein phosphatase type 2A inhibitor; Protein SET; RP11-216B9.3; SET nuclear oncogene; SET translocation (myeloid leukemia-associated); TAF-1a; TAF-1b; TAF-I; Template-activating factor I; Template-Activating Factor-I, chromatin remodelling factor

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Gene Aliases: 2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII; SET; TAF-I; TAF-IBETA

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UniProt ID: (Human) Q01105

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Entrez Gene ID: (Human) 6418

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Function(s)

DNA binding protein phosphatase inhibitor activity protein binding protein phosphatase type 2A regulator activity histone binding chromatin/chromatin-binding, or -regulatory protein

Process(es)

DNA replication nucleosome assembly nucleosome disassembly nucleocytoplasmic transport viral process regulation of protein phosphatase type 2A activity negative regulation of histone acetylation negative regulation of catalytic activity regulation of mRNA stability negative regulation of neuron apoptotic process negative regulation of transcription, DNA-templated

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SET Polyclonal Antibody

SET Antibody (55201-1-AP) in IHC (P)

Product Details

55201-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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