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SETD6 Antibody (MA5-27851) in IHC (P)
SETD6 Monoclonal Antibody (GT688) detects SETD6 protein at cytosol on human colon carcinoma by immunohistochemical analysis. Sample: Paraffin-embedded human colon carcinoma. SETD6 Monoclonal Antibody (GT688) (Product # MA5-27851) dilution: 1:100. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
Product Details
MA5-27851
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
GT688
Immunogen
Recombinant protein encompassing a sequence within the center region of human SETD6. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2735359
Product Specific Information
Positive Control: K562, THP-1, HL-60
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
SETD6 (SET domain-containing protein 6) is a 473 amino acid protein that belongs to the SETD6 family. Containing one SET domain, SETD6 is structurally similar to the Rubisco large subunit methyltransferase. SETD6 is a proteinlysine N-methyltransferase that specifically monomethylates "Lys-310" of the NFκB p65 subunit of NFκB complex, leading to down-regulate NFκB transcription factor activity. SETD6-mediated methylation renders NFκB p65 inert and attenuates NFκB p65-driven transcriptional programs, including inflammatory responses in primary immune cells. The SETD6-initiated lysine-methylation signaling cascade acts to restrain activation of NFκB-mediated inflammatory responses in diverse cell types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: N-lysine methyltransferase SETD6; SET domain-containing protein 6
Gene Aliases: SETD6
UniProt ID: (Human) Q8TBK2
Entrez Gene ID: (Human) 79918
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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