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Product Details
24840-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SETD7 Fusion Protein Ag18219 (1-366 aa encoded by BC121055)
Conjugate
Form
Liquid
Concentration
0.41 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MDSDDEMVE EAVEGHLDDD GLPHGFCTVT YSSTDRFEGN FVHGEKNGRG KFFFFDGSTL EGYYVDDALQ GQGVYTYEDG GVLQGTYVDG ELNGPAQEYD TDGRLIFKGQ YKDNIRHGVC WIYYPDGGSL VGEVNEDGEM TGEKIAYVYP DERTALYGKF IDGEMIEGKL ATLMSTEEGR PHFELMPGNS VYHFDKSTSS CISTNALLPD PYESERVYVA ESLISSAGEG LFSKVAVGPN TVMSFYNGVR ITHQEVDSRD WALNGNTLSL DEETVIDVPE PYNHVSKYCA SLGHKANHSF TPNCIYDMFV HPRFGPIKCI RTLRAVEADE ELTVAYGYDH SPPGKSGPEA PEWYQVELKA FQATQQK (1-366 aa encoded by BC121055)
Target Information
Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FLJ21193; H3-K4 methyltransferase; H3-K4-HMTase SETD7; Histone H3-K4 methyltransferase SETD7; histone H3-lysine 4-specific methyltransferase; Histone-lysine N-methyltransferase SETD7; Lysine N-methyltransferase 7; OTTHUMP00000220049; SET domain containing (lysine methyltransferase) 7; SET domain-containing protein 7; SET7/9
Gene Aliases: 1600028F23Rik; H3K4MT; KIAA1717; KMT7; mKIAA1717; SET7; SET7/9; SET9; SETD7
UniProt ID: (Human) Q8WTS6, (Mouse) Q8VHL1
Entrez Gene ID: (Human) 80854, (Rat) 689954, (Mouse) 73251
transcription, DNA-templated
cellular response to DNA damage stimulus
chromatin modification
peptidyl-lysine monomethylation
peptidyl-lysine dimethylation
histone lysine methylation
response to ethanol
positive regulation of transcription, DNA-templated
regulation of histone H3-K9 methylation
heterochromatin organization
biological_process
peptidyl-lysine methylation
negative regulation of transferase activity
regulation of transcription, DNA-templated
methylation
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