Proteintech

SETDB1 Polyclonal Antibody

SETDB1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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SETDB1 Antibody (11231-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using (Product # 11231-1-AP) (SETDB1 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

SETDB1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

11231-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 48 publications 48 publications

Immunohistochemistry (IHC)

View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

Immunocytochemistry (ICC/IF)

View 8 publications 8 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 8 publications 8 publications

ChIP assay (ChIP)

Assay-dependent

View 21 publications 21 publications

Miscellaneous PubMed (Misc)

View 2 publications 2 publications

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SETDB1 Fusion Protein Ag1725 (1-350 aa encoded by BC009362)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is a rabbit polyclonal antibody raised against residues near the N terminus of human SETDB1.The calculated molecular weight of SETDB1 is 143 kDa, but the modified SETDB1 protein is about 170 kDa.

Immunogen sequence: MSSLPGCIG LDAATATVES EEIAELQQAV VEELGISMEE LRHFIDEELE KMDCVQQRKK QLAELETWVI QKESEVAHVD QLFDDASRAV TNCESLVKDF YSKLGLQYRD SSSEDESSRP TEIIEIPDED DDVLSIDSGD AGSRTPKDQK LREAMAALRK SAQDVQKFMD AVNKKSSSQD LHKGTLSQMS GELSKDGDLI VSMRILGKKR TKTWHKGTLI AIQTVGPGKK YKVKFDNKGK SLLSGNHIAY DYHPPADKLY VGSRVVAKYK DGNQVWLYAG IVAETPNVKN KLRFLIFFDD GYASYVTQSE LYPICRPLKK TWEDIEDISC RDFIEEYVTA YPNRPMVLLK S (1-350 aa encoded by BC009362)

Target Information

This gene encodes a histone methyltransferase. The encoded enzyme catalyzes the reaction of S-adenosyl-L-methionine and histone L-lysine to produce S-adenosyl-L-homocysteine and histone N(6)-methyl-L-lysine. The encoded protein likely functions in transcriptional repression. Alternatively spliced transcript variants have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Histone methyltransferase Setdb1 mediates osteogenic differentiation by suppressing the expression of miR-212-3p under mechanical unloading.

Cellular signalling

Zhang L,Xu L,Wang Y,Zhang X,Xue T,Sun Q,Tang H,Li M,Cao X,Shi F,Zhang G,Zhang S,Hu Z

Wed Feb 01 00:00:00 EST 2023

Histone methyltransferase Setdb1 mediates osteogenic differentiation by suppressing the expression of miR-212-3p under mechanical unloading.

Cellular signalling

Zhang L,Xu L,Wang Y,Zhang X,Xue T,Sun Q,Tang H,Li M,Cao X,Shi F,Zhang G,Zhang S,Hu Z

Wed Feb 01 00:00:00 EST 2023

Histone methyltransferase Setdb1 mediates osteogenic differentiation by suppressing the expression of miR-212-3p under mechanical unloading.

Cellular signalling

Zhang L,Xu L,Wang Y,Zhang X,Xue T,Sun Q,Tang H,Li M,Cao X,Shi F,Zhang G,Zhang S,Hu Z

Wed Feb 01 00:00:00 EST 2023

Histone methyltransferase Setdb1 mediates osteogenic differentiation by suppressing the expression of miR-212-3p under mechanical unloading.

Cellular signalling

Zhang L,Xu L,Wang Y,Zhang X,Xue T,Sun Q,Tang H,Li M,Cao X,Shi F,Zhang G,Zhang S,Hu Z

Wed Feb 01 00:00:00 EST 2023

Atf7ip Inhibits Osteoblast Differentiation via Negative Regulation of the Sp7 Transcription Factor.

International journal of molecular sciences

Hu G,Shi X,Qu X,Han C,Hu A,Jia Z,Yang J,Liu H,Wu Y

Tue Feb 21 00:00:00 EST 2023

Atf7ip Inhibits Osteoblast Differentiation via Negative Regulation of the Sp7 Transcription Factor.

International journal of molecular sciences

Hu G,Shi X,Qu X,Han C,Hu A,Jia Z,Yang J,Liu H,Wu Y

Tue Feb 21 00:00:00 EST 2023

DAXX adds a de novo H3.3K9me3 deposition pathway to the histone chaperone network.

Molecular cell

Carraro M,Hendriks IA,Hammond CM,Solis-Mezarino V,Völker-Albert M,Elsborg JD,Weisser MB,Spanos C,Montoya G,Rappsilber J,Imhof A,Nielsen ML,Groth A

Thu Apr 06 00:00:00 EDT 2023

CircPTK2/PABPC1/SETDB1 axis promotes EMT-mediated tumor metastasis and gemcitabine resistance in bladder cancer.

Cancer letters

Meng X,Xiao W,Sun J,Li W,Yuan H,Yu T,Zhang X,Dong W

Wed Feb 01 00:00:00 EST 2023

CircPTK2/PABPC1/SETDB1 axis promotes EMT-mediated tumor metastasis and gemcitabine resistance in bladder cancer.

Cancer letters

Meng X,Xiao W,Sun J,Li W,Yuan H,Yu T,Zhang X,Dong W

Wed Feb 01 00:00:00 EST 2023

Mechanism of SUMOylation-Mediated Regulation of Type I IFN Expression.

Journal of molecular biology

Du L,Liu W,Rosen ST,Chen Y

Wed Mar 01 00:00:00 EST 2023

SETDB1/NSD-dependent H3K9me3/H3K36me3 dual heterochromatin maintains gene expression profiles by bookmarking poised enhancers.

Molecular cell

Barral A,Pozo G,Ducrot L,Papadopoulos GL,Sauzet S,Oldfield AJ,Cavalli G,Déjardin J

Thu Feb 17 00:00:00 EST 2022

Expression of SET domain bifurcated histone lysine methyltransferase 1 and its clinical prognostic significance in hepatocellular carcinoma.

Journal of clinical laboratory analysis

Wang C,Xia Z,Li Z,Ye F,Ji S,Lu C,Zhang H

Sat Jan 01 00:00:00 EST 2022

SETDB1 interactions with PELP1 contributes to breast cancer endocrine therapy resistance.

Breast cancer research : BCR

Liu Z,Liu J,Ebrahimi B,Pratap UP,He Y,Altwegg KA,Tang W,Li X,Lai Z,Chen Y,Shen L,Sareddy GR,Viswanadhapalli S,Tekmal RR,Rao MK,Vadlamudi RK

Fri Apr 08 00:00:00 EDT 2022

Structure and functional mapping of the KRAB-KAP1 repressor complex.

The EMBO journal

Stoll GA,Pandiloski N,Douse CH,Modis Y

Thu Dec 15 00:00:00 EST 2022

Structure and functional mapping of the KRAB-KAP1 repressor complex.

The EMBO journal

Stoll GA,Pandiloski N,Douse CH,Modis Y

Thu Dec 15 00:00:00 EST 2022

Active DNA damage response signaling initiates and maintains meiotic sex chromosome inactivation.

Nature communications

Abe H,Yeh YH,Munakata Y,Ishiguro KI,Andreassen PR,Namekawa SH

Mon Nov 28 00:00:00 EST 2022

Functional dissection of N-terminal nuclear trafficking signals of SETDB1.

Frontiers in cell and developmental biology

Eom J,Jeon K,Park JS,Kang YK

Wed Jan 11 00:00:00 EST 2023

Functional dissection of N-terminal nuclear trafficking signals of SETDB1.

Frontiers in cell and developmental biology

Eom J,Jeon K,Park JS,Kang YK

Wed Jan 11 00:00:00 EST 2023

Nucleome programming is required for the foundation of totipotency in mammalian germline development.

The EMBO journal

Nagano M,Hu B,Yokobayashi S,Yamamura A,Umemura F,Coradin M,Ohta H,Yabuta Y,Ishikura Y,Okamoto I,Ikeda H,Kawahira N,Nosaka Y,Shimizu S,Kojima Y,Mizuta K,Kasahara T,Imoto Y,Meehan K,Stocsits R,Wutz G,Hiraoka Y,Murakawa Y,Yamamoto T,Tachibana K,Peters JM,Mirny LA,Garcia BA,Majewski J,Saitou M

Mon Jul 04 00:00:00 EDT 2022

The Oligodendrocyte Transcription Factor 2 OLIG2 regulates transcriptional repression during myelinogenesis in rodents.

Nature communications

Zhang K,Chen S,Yang Q,Guo S,Chen Q,Liu Z,Li L,Jiang M,Li H,Hu J,Pan X,Deng W,Xiao N,Wang B,Wang ZX,Zhang L,Mo W

Thu Mar 17 00:00:00 EDT 2022

The Oligodendrocyte Transcription Factor 2 OLIG2 regulates transcriptional repression during myelinogenesis in rodents.

Nature communications

Zhang K,Chen S,Yang Q,Guo S,Chen Q,Liu Z,Li L,Jiang M,Li H,Hu J,Pan X,Deng W,Xiao N,Wang B,Wang ZX,Zhang L,Mo W

Thu Mar 17 00:00:00 EDT 2022

Potential dual protective effects of melatonin on spermatogonia against hexavalent chromium.

Reproductive toxicology (Elmsford, N.Y.)

Li T,Zheng Y,Li T,Guo M,Wu X,Liu R,Liu Q,You X,Zeng W,Lv Y

Mon Aug 01 00:00:00 EDT 2022

Genome surveillance by HUSH-mediated silencing of intronless mobile elements.

Nature

Seczynska M,Bloor S,Cuesta SM,Lehner PJ

Sat Jan 01 00:00:00 EST 2022

Linkage of methionine addiction, histone lysine hypermethylation, and malignancy.

iScience

Yamamoto J,Inubushi S,Han Q,Tashiro Y,Sugisawa N,Hamada K,Aoki Y,Miyake K,Matsuyama R,Bouvet M,Clarke SG,Endo I,Hoffman RM

Fri Apr 15 00:00:00 EDT 2022

Epigenetic Silencing of Recombinant Adeno-associated Virus Genomes by NP220 and the HUSH Complex.

Journal of virology

Das A,Vijayan M,Walton EM,Stafford VG,Fiflis DN,Asokan A

Wed Feb 23 00:00:00 EST 2022

Gene repression through epigenetic modulation by PPARA enhances hepatocellular proliferation.

iScience

Aibara D,Takahashi S,Yagai T,Kim D,Brocker CN,Levi M,Matsusue K,Gonzalez FJ

Fri May 20 00:00:00 EDT 2022

Gene repression through epigenetic modulation by PPARA enhances hepatocellular proliferation.

iScience

Aibara D,Takahashi S,Yagai T,Kim D,Brocker CN,Levi M,Matsusue K,Gonzalez FJ

Fri May 20 00:00:00 EDT 2022

HP1 maintains protein stability of H3K9 methyltransferases and demethylases.

EMBO reports

Maeda R,Tachibana M

Tue Apr 05 00:00:00 EDT 2022

SETDB1 Restrains Endogenous Retrovirus Expression and Antitumor Immunity during Radiotherapy.

Cancer research

Pan D,Bao X,Hu M,Jiao M,Li F,Li CY

Wed Aug 03 00:00:00 EDT 2022

Coordinated regulation of microRNA genes in C19MC by SETDB1.

Biochemical and biophysical research communications

Jeon K,Eom J,Min B,Park JS,Kang YK

Sat Dec 31 00:00:00 EST 2022

METTL1-mediated m⁷G modification of Arg-TCT tRNA drives oncogenic transformation.

Molecular cell

Orellana EA,Liu Q,Yankova E,Pirouz M,De Braekeleer E,Zhang W,Lim J,Aspris D,Sendinc E,Garyfallos DA,Gu M,Ali R,Gutierrez A,Mikutis S,Bernardes GJL,Fischer ES,Bradley A,Vassiliou GS,Slack FJ,Tzelepis K,Gregory RI

Thu Aug 19 00:00:00 EDT 2021

ZNF382 controls mouse neuropathic pain via silencer-based epigenetic inhibition of Cxcl13 in DRG neurons.

The Journal of experimental medicine

Ma L,Yu L,Jiang BC,Wang J,Guo X,Huang Y,Ren J,Sun N,Gao DS,Ding H,Lu J,Zhou H,Zou L,Gao Y,Wang L,Sun K,Ming Y,Meng Z,Tao YX,Yan M

Mon Dec 06 00:00:00 EST 2021

ZNF382 controls mouse neuropathic pain via silencer-based epigenetic inhibition of Cxcl13 in DRG neurons.

The Journal of experimental medicine

Ma L,Yu L,Jiang BC,Wang J,Guo X,Huang Y,Ren J,Sun N,Gao DS,Ding H,Lu J,Zhou H,Zou L,Gao Y,Wang L,Sun K,Ming Y,Meng Z,Tao YX,Yan M

Mon Dec 06 00:00:00 EST 2021

KDM5B promotes immune evasion by recruiting SETDB1 to silence retroelements.

Nature

Zhang SM,Cai WL,Liu X,Thakral D,Luo J,Chan LH,McGeary MK,Song E,Blenman KRM,Micevic G,Jessel S,Zhang Y,Yin M,Booth CJ,Jilaveanu LB,Damsky W,Sznol M,Kluger HM,Iwasaki A,Bosenberg MW,Yan Q

Fri Oct 01 00:00:00 EDT 2021

KDM5B promotes immune evasion by recruiting SETDB1 to silence retroelements.

Nature

Zhang SM,Cai WL,Liu X,Thakral D,Luo J,Chan LH,McGeary MK,Song E,Blenman KRM,Micevic G,Jessel S,Zhang Y,Yin M,Booth CJ,Jilaveanu LB,Damsky W,Sznol M,Kluger HM,Iwasaki A,Bosenberg MW,Yan Q

Fri Oct 01 00:00:00 EDT 2021

KDM5B promotes immune evasion by recruiting SETDB1 to silence retroelements.

Nature

Zhang SM,Cai WL,Liu X,Thakral D,Luo J,Chan LH,McGeary MK,Song E,Blenman KRM,Micevic G,Jessel S,Zhang Y,Yin M,Booth CJ,Jilaveanu LB,Damsky W,Sznol M,Kluger HM,Iwasaki A,Bosenberg MW,Yan Q

Fri Oct 01 00:00:00 EDT 2021

The RNA m⁶A reader YTHDC1 silences retrotransposons and guards ES cell identity.

Nature

Liu J,Gao M,He J,Wu K,Lin S,Jin L,Chen Y,Liu H,Shi J,Wang X,Chang L,Lin Y,Zhao YL,Zhang X,Zhang M,Luo GZ,Wu G,Pei D,Wang J,Bao X,Chen J

Mon Mar 01 00:00:00 EST 2021

The RNA m⁶A reader YTHDC1 silences retrotransposons and guards ES cell identity.

Nature

Liu J,Gao M,He J,Wu K,Lin S,Jin L,Chen Y,Liu H,Shi J,Wang X,Chang L,Lin Y,Zhao YL,Zhang X,Zhang M,Luo GZ,Wu G,Pei D,Wang J,Bao X,Chen J

Mon Mar 01 00:00:00 EST 2021

Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity.

Nature

Griffin GK,Wu J,Iracheta-Vellve A,Patti JC,Hsu J,Davis T,Dele-Oni D,Du PP,Halawi AG,Ishizuka JJ,Kim SY,Klaeger S,Knudsen NH,Miller BC,Nguyen TH,Olander KE,Papanastasiou M,Rachimi S,Robitschek EJ,Schneider EM,Yeary MD,Zimmer MD,Jaffe JD,Carr SA,Doench JG,Haining WN,Yates KB,Manguso RT,Bernstein BE

Thu Jul 01 00:00:00 EDT 2021

KAP1-Mediated Epigenetic Suppression in Anti-RNA Viral Responses by Direct Targeting RIG-I and MDA5.

Journal of immunology (Baltimore, Md. : 1950)

Li Q,Qin Y,Wang W,Jia M,Zhao W,Zhao C

Fri Oct 01 00:00:00 EDT 2021

ATRX limits the accessibility of histone H3-occupied HSV genomes during lytic infection.

PLoS pathogens

Cabral JM,Cushman CH,Sodroski CN,Knipe DM

Thu Apr 01 00:00:00 EDT 2021

Repression of germline genes by PRC1.6 and SETDB1 in the early embryo precedes DNA methylation-mediated silencing.

Nature communications

Mochizuki K,Sharif J,Shirane K,Uranishi K,Bogutz AB,Janssen SM,Suzuki A,Okuda A,Koseki H,Lorincz MC

Thu Dec 02 00:00:00 EST 2021

METTL3 regulates heterochromatin in mouse embryonic stem cells.

Nature

Xu W,Li J,He C,Wen J,Ma H,Rong B,Diao J,Wang L,Wang J,Wu F,Tan L,Shi YG,Shi Y,Shen H

Mon Mar 01 00:00:00 EST 2021

TRIM28 inhibits alternative lengthening of telomere phenotypes by protecting SETDB1 from degradation.

Cell & bioscience

Wang C,Songyang Z,Huang Y

Fri Jul 30 00:00:00 EDT 2021

TRIM28 inhibits alternative lengthening of telomere phenotypes by protecting SETDB1 from degradation.

Cell & bioscience

Wang C,Songyang Z,Huang Y

Fri Jul 30 00:00:00 EDT 2021

DICER regulates the expression of major satellite repeat transcripts and meiotic chromosome segregation during spermatogenesis.

Nucleic acids research

Yadav RP,Mäkelä JA,Hyssälä H,Cisneros-Montalvo S,Kotaja N

Mon Jul 27 00:00:00 EDT 2020

DICER regulates the expression of major satellite repeat transcripts and meiotic chromosome segregation during spermatogenesis.

Nucleic acids research

Yadav RP,Mäkelä JA,Hyssälä H,Cisneros-Montalvo S,Kotaja N

Mon Jul 27 00:00:00 EDT 2020

High SET Domain Bifurcated 1 (SETDB1) Expression Predicts Poor Prognosis in Breast Carcinoma.

Medical science monitor : international medical journal of experimental and clinical research

Zhou Z,Wu B,Tang X,Yang W,Zou Q,Wang H

Sun Apr 19 00:00:00 EDT 2020

SETDB1 Inhibits p53-Mediated Apoptosis and Is Required for Formation of Pancreatic Ductal Adenocarcinomas in Mice.

Gastroenterology

Ogawa S,Fukuda A,Matsumoto Y,Hanyu Y,Sono M,Fukunaga Y,Masuda T,Araki O,Nagao M,Yoshikawa T,Goto N,Hiramatsu Y,Tsuda M,Maruno T,Nakanishi Y,Hussein MS,Tsuruyama T,Takaori K,Uemoto S,Seno H

Sat Aug 01 00:00:00 EDT 2020

SETDB1 Inhibits p53-Mediated Apoptosis and Is Required for Formation of Pancreatic Ductal Adenocarcinomas in Mice.

Gastroenterology

Ogawa S,Fukuda A,Matsumoto Y,Hanyu Y,Sono M,Fukunaga Y,Masuda T,Araki O,Nagao M,Yoshikawa T,Goto N,Hiramatsu Y,Tsuda M,Maruno T,Nakanishi Y,Hussein MS,Tsuruyama T,Takaori K,Uemoto S,Seno H

Sat Aug 01 00:00:00 EDT 2020

SETDB1 Inhibits p53-Mediated Apoptosis and Is Required for Formation of Pancreatic Ductal Adenocarcinomas in Mice.

Gastroenterology

Ogawa S,Fukuda A,Matsumoto Y,Hanyu Y,Sono M,Fukunaga Y,Masuda T,Araki O,Nagao M,Yoshikawa T,Goto N,Hiramatsu Y,Tsuda M,Maruno T,Nakanishi Y,Hussein MS,Tsuruyama T,Takaori K,Uemoto S,Seno H

Sat Aug 01 00:00:00 EDT 2020

SETDB1 Inhibits p53-Mediated Apoptosis and Is Required for Formation of Pancreatic Ductal Adenocarcinomas in Mice.

Gastroenterology

Ogawa S,Fukuda A,Matsumoto Y,Hanyu Y,Sono M,Fukunaga Y,Masuda T,Araki O,Nagao M,Yoshikawa T,Goto N,Hiramatsu Y,Tsuda M,Maruno T,Nakanishi Y,Hussein MS,Tsuruyama T,Takaori K,Uemoto S,Seno H

Sat Aug 01 00:00:00 EDT 2020

SETDB1 Inhibits p53-Mediated Apoptosis and Is Required for Formation of Pancreatic Ductal Adenocarcinomas in Mice.

Gastroenterology

Ogawa S,Fukuda A,Matsumoto Y,Hanyu Y,Sono M,Fukunaga Y,Masuda T,Araki O,Nagao M,Yoshikawa T,Goto N,Hiramatsu Y,Tsuda M,Maruno T,Nakanishi Y,Hussein MS,Tsuruyama T,Takaori K,Uemoto S,Seno H

Sat Aug 01 00:00:00 EDT 2020

SETDB1 Inhibits p53-Mediated Apoptosis and Is Required for Formation of Pancreatic Ductal Adenocarcinomas in Mice.

Gastroenterology

Ogawa S,Fukuda A,Matsumoto Y,Hanyu Y,Sono M,Fukunaga Y,Masuda T,Araki O,Nagao M,Yoshikawa T,Goto N,Hiramatsu Y,Tsuda M,Maruno T,Nakanishi Y,Hussein MS,Tsuruyama T,Takaori K,Uemoto S,Seno H

Sat Aug 01 00:00:00 EDT 2020

SETDB1 promotes the progression of colorectal cancer via epigenetically silencing p21 expression.

Cell death & disease

Cao N,Yu Y,Zhu H,Chen M,Chen P,Zhuo M,Mao Y,Li L,Zhao Q,Wu M,Ye M

Mon May 11 00:00:00 EDT 2020

SETDB1 promotes the progression of colorectal cancer via epigenetically silencing p21 expression.

Cell death & disease

Cao N,Yu Y,Zhu H,Chen M,Chen P,Zhuo M,Mao Y,Li L,Zhao Q,Wu M,Ye M

Mon May 11 00:00:00 EDT 2020

PIWIL4 Maintains HIV-1 Latency by Enforcing Epigenetically Suppressive Modifications on the 5' Long Terminal Repeat.

Journal of virology

He Z,Jing S,Yang T,Chen J,Huang F,Zhang W,Peng Z,Liu B,Ma X,Wu L,Pan T,Zhang X,Li L,Cai W,Tang X,Zhang J,Zhang H

Mon May 04 00:00:00 EDT 2020

PIWIL4 Maintains HIV-1 Latency by Enforcing Epigenetically Suppressive Modifications on the 5' Long Terminal Repeat.

Journal of virology

He Z,Jing S,Yang T,Chen J,Huang F,Zhang W,Peng Z,Liu B,Ma X,Wu L,Pan T,Zhang X,Li L,Cai W,Tang X,Zhang J,Zhang H

Mon May 04 00:00:00 EDT 2020

The Histone Methyltransferase SETDB1 Modulates Survival of Spermatogonial Stem/Progenitor Cells Through NADPH Oxidase.

Frontiers in genetics

Li X,Chen X,Liu Y,Zhang P,Zheng Y,Zeng W

Tue Nov 03 00:00:00 EST 2020

The Histone Methyltransferase SETDB1 Modulates Survival of Spermatogonial Stem/Progenitor Cells Through NADPH Oxidase.

Frontiers in genetics

Li X,Chen X,Liu Y,Zhang P,Zheng Y,Zeng W

Tue Nov 03 00:00:00 EST 2020

Hdac3, Setdb1, and Kap1 mark H3K9me3/H3K14ac bivalent regions in young and aged liver.

Aging cell

Price AJ,Manjegowda MC,Kain J,Anandh S,Bochkis IM

Sat Feb 01 00:00:00 EST 2020

Hdac3, Setdb1, and Kap1 mark H3K9me3/H3K14ac bivalent regions in young and aged liver.

Aging cell

Price AJ,Manjegowda MC,Kain J,Anandh S,Bochkis IM

Sat Feb 01 00:00:00 EST 2020

Defect of SLC38A3 promotes epithelial-mesenchymal transition and predicts poor prognosis in esophageal squamous cell carcinoma.

Chinese journal of cancer research = Chung-kuo yen cheng yen chiu

Liu R,Hong R,Wang Y,Gong Y,Yeerken D,Yang D,Li J,Fan J,Chen J,Zhang W,Zhan Q

Sat Oct 31 00:00:00 EDT 2020

Defect of SLC38A3 promotes epithelial-mesenchymal transition and predicts poor prognosis in esophageal squamous cell carcinoma.

Chinese journal of cancer research = Chung-kuo yen cheng yen chiu

Liu R,Hong R,Wang Y,Gong Y,Yeerken D,Yang D,Li J,Fan J,Chen J,Zhang W,Zhan Q

Sat Oct 31 00:00:00 EDT 2020

Defect of SLC38A3 promotes epithelial-mesenchymal transition and predicts poor prognosis in esophageal squamous cell carcinoma.

Chinese journal of cancer research = Chung-kuo yen cheng yen chiu

Liu R,Hong R,Wang Y,Gong Y,Yeerken D,Yang D,Li J,Fan J,Chen J,Zhang W,Zhan Q

Sat Oct 31 00:00:00 EDT 2020

ATF7IP regulates SETDB1 nuclear localization and increases its ubiquitination.

EMBO reports

Tsusaka T,Shimura C,Shinkai Y

Thu Dec 05 00:00:00 EST 2019

AFF3-DNA methylation interplay in maintaining the mono-allelic expression pattern of XIST in terminally differentiated cells.

Journal of molecular cell biology

Zhang Y,Wang C,Liu X,Yang Q,Ji H,Yang M,Xu M,Zhou Y,Xie W,Luo Z,Lin C

Thu Sep 19 00:00:00 EDT 2019

AFF3-DNA methylation interplay in maintaining the mono-allelic expression pattern of XIST in terminally differentiated cells.

Journal of molecular cell biology

Zhang Y,Wang C,Liu X,Yang Q,Ji H,Yang M,Xu M,Zhou Y,Xie W,Luo Z,Lin C

Thu Sep 19 00:00:00 EDT 2019

SETDB1 induces epithelial‑mesenchymal transition in breast carcinoma by directly binding with Snail promoter.

Oncology reports

Yang W,Su Y,Hou C,Chen L,Zhou D,Ren K,Zhou Z,Zhang R,Liu X

Fri Feb 01 00:00:00 EST 2019

SETDB1 induces epithelial‑mesenchymal transition in breast carcinoma by directly binding with Snail promoter.

Oncology reports

Yang W,Su Y,Hou C,Chen L,Zhou D,Ren K,Zhou Z,Zhang R,Liu X

Fri Feb 01 00:00:00 EST 2019

SETDB1 induces epithelial‑mesenchymal transition in breast carcinoma by directly binding with Snail promoter.

Oncology reports

Yang W,Su Y,Hou C,Chen L,Zhou D,Ren K,Zhou Z,Zhang R,Liu X

Fri Feb 01 00:00:00 EST 2019

AKT methylation by SETDB1 promotes AKT kinase activity and oncogenic functions.

Nature cell biology

Guo J,Dai X,Laurent B,Zheng N,Gan W,Zhang J,Guo A,Yuan M,Liu P,Asara JM,Toker A,Shi Y,Pandolfi PP,Wei W

Fri Feb 01 00:00:00 EST 2019

SETDB1 Links the Meiotic DNA Damage Response to Sex Chromosome Silencing in Mice.

Developmental cell

Hirota T,Blakeley P,Sangrithi MN,Mahadevaiah SK,Encheva V,Snijders AP,ElInati E,Ojarikre OA,de Rooij DG,Niakan KK,Turner JMA

Mon Dec 03 00:00:00 EST 2018

SETDB1 Links the Meiotic DNA Damage Response to Sex Chromosome Silencing in Mice.

Developmental cell

Hirota T,Blakeley P,Sangrithi MN,Mahadevaiah SK,Encheva V,Snijders AP,ElInati E,Ojarikre OA,de Rooij DG,Niakan KK,Turner JMA

Mon Dec 03 00:00:00 EST 2018

SETDB1 Links the Meiotic DNA Damage Response to Sex Chromosome Silencing in Mice.

Developmental cell

Hirota T,Blakeley P,Sangrithi MN,Mahadevaiah SK,Encheva V,Snijders AP,ElInati E,Ojarikre OA,de Rooij DG,Niakan KK,Turner JMA

Mon Dec 03 00:00:00 EST 2018

SETDB1 Links the Meiotic DNA Damage Response to Sex Chromosome Silencing in Mice.

Developmental cell

Hirota T,Blakeley P,Sangrithi MN,Mahadevaiah SK,Encheva V,Snijders AP,ElInati E,Ojarikre OA,de Rooij DG,Niakan KK,Turner JMA

Mon Dec 03 00:00:00 EST 2018

SETDB1 is essential for mouse primordial germ cell fate determination by ensuring BMP signaling.

Development (Cambridge, England)

Mochizuki K,Tando Y,Sekinaka T,Otsuka K,Hayashi Y,Kobayashi H,Kamio A,Ito-Matsuoka Y,Takehara A,Kono T,Osumi N,Matsui Y

Mon Dec 03 00:00:00 EST 2018

SETDB1 is essential for mouse primordial germ cell fate determination by ensuring BMP signaling.

Development (Cambridge, England)

Mochizuki K,Tando Y,Sekinaka T,Otsuka K,Hayashi Y,Kobayashi H,Kamio A,Ito-Matsuoka Y,Takehara A,Kono T,Osumi N,Matsui Y

Mon Dec 03 00:00:00 EST 2018

Melatonin protects mouse spermatogonial stem cells against hexavalent chromium-induced apoptosis and epigenetic histone modification.

Toxicology and applied pharmacology

Lv Y,Zhang P,Guo J,Zhu Z,Li X,Xu D,Zeng W

Thu Feb 01 00:00:00 EST 2018

Melatonin protects mouse spermatogonial stem cells against hexavalent chromium-induced apoptosis and epigenetic histone modification.

Toxicology and applied pharmacology

Lv Y,Zhang P,Guo J,Zhu Z,Li X,Xu D,Zeng W

Thu Feb 01 00:00:00 EST 2018

SUMO Safeguards Somatic and Pluripotent Cell Identities by Enforcing Distinct Chromatin States.

Cell stem cell

Cossec JC,Theurillat I,Chica C,Búa Aguín S,Gaume X,Andrieux A,Iturbide A,Jouvion G,Li H,Bossis G,Seeler JS,Torres-Padilla ME,Dejean A

Thu Nov 01 00:00:00 EDT 2018

SUMO Safeguards Somatic and Pluripotent Cell Identities by Enforcing Distinct Chromatin States.

Cell stem cell

Cossec JC,Theurillat I,Chica C,Búa Aguín S,Gaume X,Andrieux A,Iturbide A,Jouvion G,Li H,Bossis G,Seeler JS,Torres-Padilla ME,Dejean A

Thu Nov 01 00:00:00 EDT 2018

Primate immunodeficiency virus proteins Vpx and Vpr counteract transcriptional repression of proviruses by the HUSH complex.

Nature microbiology

Yurkovetskiy L,Guney MH,Kim K,Goh SL,McCauley S,Dauphin A,Diehl WE,Luban J

Sat Dec 01 00:00:00 EST 2018

Primate immunodeficiency virus proteins Vpx and Vpr counteract transcriptional repression of proviruses by the HUSH complex.

Nature microbiology

Yurkovetskiy L,Guney MH,Kim K,Goh SL,McCauley S,Dauphin A,Diehl WE,Luban J

Sat Dec 01 00:00:00 EST 2018

Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2.

Nature genetics

Tchasovnikarova IA,Timms RT,Douse CH,Roberts RC,Dougan G,Kingston RE,Modis Y,Lehner PJ

Sat Jul 01 00:00:00 EDT 2017

Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2.

Nature genetics

Tchasovnikarova IA,Timms RT,Douse CH,Roberts RC,Dougan G,Kingston RE,Modis Y,Lehner PJ

Sat Jul 01 00:00:00 EDT 2017

Histone methyltransferase SETDB1 maintains survival of mouse spermatogonial stem/progenitor cells via PTEN/AKT/FOXO1 pathway.

Biochimica et biophysica acta. Gene regulatory mechanisms

Liu T,Chen X,Li T,Li X,Lyu Y,Fan X,Zhang P,Zeng W

Sun Oct 01 00:00:00 EDT 2017

Histone methyltransferase SETDB1 maintains survival of mouse spermatogonial stem/progenitor cells via PTEN/AKT/FOXO1 pathway.

Biochimica et biophysica acta. Gene regulatory mechanisms

Liu T,Chen X,Li T,Li X,Lyu Y,Fan X,Zhang P,Zeng W

Sun Oct 01 00:00:00 EDT 2017

Histone Methyltransferase SETDB1 Promotes the Progression of Colorectal Cancer by Inhibiting the Expression of TP53.

Journal of Cancer

Chen K,Zhang F,Ding J,Liang Y,Zhan Z,Zhan Y,Chen LH,Ding Y

Thu Mar 17 00:00:00 EDT 2022

Histone Methyltransferase SETDB1 Promotes the Progression of Colorectal Cancer by Inhibiting the Expression of TP53.

Journal of Cancer

Chen K,Zhang F,Ding J,Liang Y,Zhan Z,Zhan Y,Chen LH,Ding Y

Thu Mar 17 00:00:00 EDT 2022

A Histone Methyltransferase ESET Is Critical for T Cell Development.

Journal of immunology (Baltimore, Md. : 1950)

Takikita S,Muro R,Takai T,Otsubo T,Kawamura YI,Dohi T,Oda H,Kitajima M,Oshima K,Hattori M,Endo TA,Toyoda T,Weis J,Shinkai Y,Suzuki H

Thu Sep 15 00:00:00 EDT 2016

Hypomethylation of ERVs in the sperm of mice haploinsufficient for the histone methyltransferase Setdb1 correlates with a paternal effect on phenotype.

Scientific reports

Daxinger L,Oey H,Isbel L,Whitelaw NC,Youngson NA,Spurling A,Vonk KK,Whitelaw E

Tue Apr 26 00:00:00 EDT 2016

Hypomethylation of ERVs in the sperm of mice haploinsufficient for the histone methyltransferase Setdb1 correlates with a paternal effect on phenotype.

Scientific reports

Daxinger L,Oey H,Isbel L,Whitelaw NC,Youngson NA,Spurling A,Vonk KK,Whitelaw E

Tue Apr 26 00:00:00 EDT 2016

ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex.

Cell reports

Timms RT,Tchasovnikarova IA,Antrobus R,Dougan G,Lehner PJ

Tue Oct 11 00:00:00 EDT 2016

ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex.

Cell reports

Timms RT,Tchasovnikarova IA,Antrobus R,Dougan G,Lehner PJ

Tue Oct 11 00:00:00 EDT 2016

Activation of Endogenous Retroviruses in Dnmt1(-/-) ESCs Involves Disruption of SETDB1-Mediated Repression by NP95 Binding to Hemimethylated DNA.

Cell stem cell

Sharif J,Endo TA,Nakayama M,Karimi MM,Shimada M,Katsuyama K,Goyal P,Brind'Amour J,Sun MA,Sun Z,Ishikura T,Mizutani-Koseki Y,Ohara O,Shinkai Y,Nakanishi M,Xie H,Lorincz MC,Koseki H

Thu Jul 07 00:00:00 EDT 2016

Activation of Endogenous Retroviruses in Dnmt1(-/-) ESCs Involves Disruption of SETDB1-Mediated Repression by NP95 Binding to Hemimethylated DNA.

Cell stem cell

Sharif J,Endo TA,Nakayama M,Karimi MM,Shimada M,Katsuyama K,Goyal P,Brind'Amour J,Sun MA,Sun Z,Ishikura T,Mizutani-Koseki Y,Ohara O,Shinkai Y,Nakanishi M,Xie H,Lorincz MC,Koseki H

Thu Jul 07 00:00:00 EDT 2016

Activation of Endogenous Retroviruses in Dnmt1(-/-) ESCs Involves Disruption of SETDB1-Mediated Repression by NP95 Binding to Hemimethylated DNA.

Cell stem cell

Sharif J,Endo TA,Nakayama M,Karimi MM,Shimada M,Katsuyama K,Goyal P,Brind'Amour J,Sun MA,Sun Z,Ishikura T,Mizutani-Koseki Y,Ohara O,Shinkai Y,Nakanishi M,Xie H,Lorincz MC,Koseki H

Thu Jul 07 00:00:00 EDT 2016

Activation of Endogenous Retroviruses in Dnmt1(-/-) ESCs Involves Disruption of SETDB1-Mediated Repression by NP95 Binding to Hemimethylated DNA.

Cell stem cell

Sharif J,Endo TA,Nakayama M,Karimi MM,Shimada M,Katsuyama K,Goyal P,Brind'Amour J,Sun MA,Sun Z,Ishikura T,Mizutani-Koseki Y,Ohara O,Shinkai Y,Nakanishi M,Xie H,Lorincz MC,Koseki H

Thu Jul 07 00:00:00 EDT 2016

GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells.

Science (New York, N.Y.)

Tchasovnikarova IA,Timms RT,Matheson NJ,Wals K,Antrobus R,Göttgens B,Dougan G,Dawson MA,Lehner PJ

Fri Jun 26 00:00:00 EDT 2015

GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells.

Science (New York, N.Y.)

Tchasovnikarova IA,Timms RT,Matheson NJ,Wals K,Antrobus R,Göttgens B,Dougan G,Dawson MA,Lehner PJ

Fri Jun 26 00:00:00 EDT 2015

The histone methyltransferase SETDB1 represses endogenous and exogenous retroviruses in B lymphocytes.

Proceedings of the National Academy of Sciences of the United States of America

Collins PL,Kyle KE,Egawa T,Shinkai Y,Oltz EM

Tue Jul 07 00:00:00 EDT 2015

The histone methyltransferase SETDB1 represses endogenous and exogenous retroviruses in B lymphocytes.

Proceedings of the National Academy of Sciences of the United States of America

Collins PL,Kyle KE,Egawa T,Shinkai Y,Oltz EM

Tue Jul 07 00:00:00 EDT 2015

SETDB1 accelerates tumourigenesis by regulating the WNT signalling pathway.

The Journal of pathology

Sun QY,Ding LW,Xiao JF,Chien W,Lim SL,Hattori N,Goodglick L,Chia D,Mah V,Alavi M,Kim SR,Doan NB,Said JW,Loh XY,Xu L,Liu LZ,Yang H,Hayano T,Shi S,Xie D,Lin DC,Koeffler HP

Sun Mar 01 00:00:00 EST 2015

SETDB1 accelerates tumourigenesis by regulating the WNT signalling pathway.

The Journal of pathology

Sun QY,Ding LW,Xiao JF,Chien W,Lim SL,Hattori N,Goodglick L,Chia D,Mah V,Alavi M,Kim SR,Doan NB,Said JW,Loh XY,Xu L,Liu LZ,Yang H,Hayano T,Shi S,Xie D,Lin DC,Koeffler HP

Sun Mar 01 00:00:00 EST 2015

SETDB1 accelerates tumourigenesis by regulating the WNT signalling pathway.

The Journal of pathology

Sun QY,Ding LW,Xiao JF,Chien W,Lim SL,Hattori N,Goodglick L,Chia D,Mah V,Alavi M,Kim SR,Doan NB,Said JW,Loh XY,Xu L,Liu LZ,Yang H,Hayano T,Shi S,Xie D,Lin DC,Koeffler HP

Sun Mar 01 00:00:00 EST 2015

SETDB1 accelerates tumourigenesis by regulating the WNT signalling pathway.

The Journal of pathology

Sun QY,Ding LW,Xiao JF,Chien W,Lim SL,Hattori N,Goodglick L,Chia D,Mah V,Alavi M,Kim SR,Doan NB,Said JW,Loh XY,Xu L,Liu LZ,Yang H,Hayano T,Shi S,Xie D,Lin DC,Koeffler HP

Sun Mar 01 00:00:00 EST 2015

KMT1E-mediated chromatin modifications at the FcγRIIb promoter regulate thymocyte development.

Genes and immunity

Martin FJ,Xu Y,Lohmann F,Ciccone DN,Nicholson TB,Loureiro JJ,Chen T,Huang Q

Sun Mar 01 00:00:00 EST 2015

KMT1E-mediated chromatin modifications at the FcγRIIb promoter regulate thymocyte development.

Genes and immunity

Martin FJ,Xu Y,Lohmann F,Ciccone DN,Nicholson TB,Loureiro JJ,Chen T,Huang Q

Sun Mar 01 00:00:00 EST 2015

Setdb1 is required for myogenic differentiation of C2C12 myoblast cells via maintenance of MyoD expression.

Molecules and cells

Song YJ,Choi JH,Lee H

Wed Apr 01 00:00:00 EDT 2015

Reactivation of maternal SNORD116 cluster via SETDB1 knockdown in Prader-Willi syndrome iPSCs.

Human molecular genetics

Cruvinel E,Budinetz T,Germain N,Chamberlain S,Lalande M,Martins-Taylor K

Mon Sep 01 00:00:00 EDT 2014

Reactivation of maternal SNORD116 cluster via SETDB1 knockdown in Prader-Willi syndrome iPSCs.

Human molecular genetics

Cruvinel E,Budinetz T,Germain N,Chamberlain S,Lalande M,Martins-Taylor K

Mon Sep 01 00:00:00 EDT 2014

The histone methyltransferase ESET is required for the survival of spermatogonial stem/progenitor cells in mice.

Cell death & disease