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Product Details
PA5-29390
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to a region within amino acids 231 and 295 of Human FRP 2
Conjugate
Form
Liquid
Concentration
1.12 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2546866
Product Specific Information
Recommended positive controls: A431, HeLa.
Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (100%), Dog (100%), Pig (100%), Sheep (100%), Chimpanzee (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FRP 2; FRP-2; MGC128911; MGC153618; MGC53344; SARP 1; SARP-1; SDF 5; secreted apoptosis related protein 1; Secreted apoptosis-related protein 1; Secreted frizzled-related protein 2; sFRP 2; sFRP-2; Sfrp2 protein; testicular tissue protein Li 170
Gene Aliases: FKSG12; FRP-2; FRP2; SARP1; SDF-5; SFRP2; UNQ361/PRO697
UniProt ID: (Human) Q96HF1
Entrez Gene ID: (Human) 6423
patterning of blood vessels
chondrocyte development
outflow tract morphogenesis
cardiac left ventricle morphogenesis
apoptotic process
G-protein coupled receptor signaling pathway
cell-cell signaling
response to nutrient
positive regulation of cell proliferation
negative regulation of cell proliferation
male gonad development
negative regulation of gene expression
negative regulation of cardiac muscle cell apoptotic process
negative regulation of epithelial to mesenchymal transition
positive regulation of endopeptidase activity
negative regulation of Wnt signaling pathway
collagen fibril organization
positive regulation of cell growth
negative regulation of cell growth
negative regulation of cell migration
negative regulation of BMP signaling pathway
cellular response to extracellular stimulus
positive regulation of peptidyl-serine phosphorylation
positive regulation of cell adhesion mediated by integrin
positive regulation of catenin import into nucleus
non-canonical Wnt signaling pathway
post-anal tail morphogenesis
response to drug
negative regulation of mesodermal cell fate specification
embryonic digit morphogenesis
positive regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of JUN kinase activity
positive regulation of fat cell differentiation
positive regulation of osteoblast differentiation
positive regulation of angiogenesis
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
digestive tract morphogenesis
negative regulation of epithelial cell proliferation
negative regulation of peptidyl-tyrosine phosphorylation
convergent extension involved in axis elongation
bone morphogenesis
sclerotome development
negative regulation of dermatome development
hematopoietic stem cell proliferation
cellular response to X-ray
negative regulation of canonical Wnt signaling pathway
planar cell polarity pathway involved in neural tube closure
Wnt signaling pathway involved in somitogenesis
positive regulation of canonical Wnt signaling pathway
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
regulation of dopaminergic neuron differentiation
midbrain morphogenesis
regulation of stem cell division
negative regulation of planar cell polarity pathway involved in axis elongation
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