Proteintech

SFRS2 Polyclonal Antibody

SFRS2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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SFRS2 Antibody (20371-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using 20371-1-AP (SFRS2 antibody) at dilution of 1:200 (under 10x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

SFRS2 Antibody in Immunoprecipitation (IP)

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Product Details

20371-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

The antibody has no cross reaction to SFRS2B.

Target Information

The protein encoded by SC35 is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding the same protein and one non-coding transcript variant have been found for SC35. In addition, a pseudogene of SC35 has been found on chromosome 11.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

SRSF2 in Sertoli cells is essential for testicular development and spermatogenesis in mice.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Xie X,Sun L,Duan Y,Lv Z,Yao X,Wang C,Chen X,Tian S,Yan L,Shao Y,Luo H,Liu J

Mon May 01 00:00:00 EDT 2023

SRSF protein kinase 1 modulates RAN translation and suppresses CGG repeat toxicity.

EMBO molecular medicine

Malik I,Tseng YJ,Wright SE,Zheng K,Ramaiyer P,Green KM,Todd PK

Mon Nov 08 00:00:00 EST 2021

SFRS11 Loss Leads to Aging-Associated Cognitive Decline by Modulating LRP8 and ApoE.

Cell reports

Raihan O,Brishti A,Li Q,Zhang Q,Li D,Li X,Zhang Q,Xie Z,Li J,Zhang J,Liu Q

Tue Jul 02 00:00:00 EDT 2019

The Age-dependent Elevation of miR-335-3p Leads to Reduced Cholesterol and Impaired Memory in Brain.

Neuroscience

Raihan O,Brishti A,Molla MR,Li W,Zhang Q,Xu P,Khan MI,Zhang J,Liu Q

Mon Oct 15 00:00:00 EDT 2018

The Age-dependent Elevation of miR-335-3p Leads to Reduced Cholesterol and Impaired Memory in Brain.

Neuroscience

Raihan O,Brishti A,Molla MR,Li W,Zhang Q,Xu P,Khan MI,Zhang J,Liu Q

Mon Oct 15 00:00:00 EDT 2018

Mutually exclusive acetylation and ubiquitylation of the splicing factor SRSF5 control tumor growth.

Nature communications

Chen Y,Huang Q,Liu W,Zhu Q,Cui CP,Xu L,Guo X,Wang P,Liu J,Dong G,Wei W,Liu CH,Feng Z,He F,Zhang L

Mon Jun 25 00:00:00 EDT 2018

Mutually exclusive acetylation and ubiquitylation of the splicing factor SRSF5 control tumor growth.

Nature communications

Chen Y,Huang Q,Liu W,Zhu Q,Cui CP,Xu L,Guo X,Wang P,Liu J,Dong G,Wei W,Liu CH,Feng Z,He F,Zhang L

Mon Jun 25 00:00:00 EDT 2018

Bioinformatics

Protein Aliases: MRF-1; myelin regulatory factor 1; Protein PR264; Putative myelin regulatory factor 1; SC-35; Serine/arginine-rich splicing factor 2; Splicing component, 35 kDa; Splicing factor SC35; Splicing factor, arginine/serine-rich 2; splicing factor, arginine/serine-rich 2 (SC-35); SR splicing factor 2

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Gene Aliases: D11Wsu175e; MRF-1; PR264; SC-35; SC35; Sfrs10; SFRS2; SFRS2A; SRp30b; SRSF2

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UniProt ID: (Human) Q01130, (Mouse) Q62093, (Rat) Q6PDU1

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Entrez Gene ID: (Human) 6427, (Mouse) 20382, (Rat) 494445

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Function(s)

nucleotide binding transcription corepressor activity protein binding pre-mRNA binding poly(A) RNA binding nucleic acid binding RNA binding RNA splicing factor

Process(es)

regulation of alternative mRNA splicing, via spliceosome mRNA splicing, via spliceosome termination of RNA polymerase II transcription mRNA processing RNA export from nucleus mRNA export from nucleus RNA splicing mRNA 3'-end processing negative regulation of nucleic acid-templated transcription

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SFRS2 Polyclonal Antibody

SFRS2 Antibody (20371-1-AP) in IHC (P)

Product Details

20371-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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