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Product Details
10774-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SFTPC Fusion Protein Ag1159 (1-197 aa encoded by BC005913)
Conjugate
Form
Liquid
Concentration
0.32 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody (Product # 10774-1-AP) is a rabbit polyclonal antibody raised with the full-length SFTPC of human origin.
Immunogen sequence: MDVGSKEVL MESPPDYSAA PRGRFGIPCC PVHLKRLLIV VVVVVLIVVV IVGALLMGLH MSQKHTEMVL EMSIGAPEAQ QRLALSEHLV TTATFSIGST GLVVYDYQQL LIAYKPAPGT CCYIMKIAPE SIPSLEALNR KVHNFQMECS LQAKPAVPTS KLGQAEGRDA GSAPSGGDPA FLGMAVNTLC GEVPLYYI (1-197 aa encoded by BC005913)
Target Information
This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: BRICHOS domain containing 6; PSP C; pulmonary surfactant apoprotein-2 SP-C; Pulmonary surfactant-associated protein C; Pulmonary surfactant-associated proteolipid SPL(Val); SFTP 2; SP C; SP-C; SP5; surfactant associated protein C; Surfactant protein C; Surfactant pulmonary-associated protein C; Surfactant, pulmonary-associated protein C
Gene Aliases: BRICD6; pro-SpC; PSP-C; Sftp-2; SFTP2; SFTPC; SMDP2; SP-C; SP5; SPC
UniProt ID: (Human) P11686, (Rat) P11685
Entrez Gene ID: (Human) 6440, (Mouse) 20389, (Rat) 50683
respiratory gaseous exchange
cellular protein metabolic process
protein homooligomerization
circadian rhythm
response to hormone
response to glucose
response to organic substance
response to lipopolysaccharide
response to retinoic acid
response to vitamin A
regulation of liquid surface tension
response to glucocorticoid
response to cAMP
response to hyperoxia
response to interleukin-6
response to growth factor
cellular response to mechanical stimulus
cellular response to nitric oxide
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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