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Product Details
PA5-87746
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 172-431 of human SGK1 (NP_0056182)
Conjugate
Form
Liquid
Concentration
1.5 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2804383
Product Specific Information
Positive Samples: HeLa, Jurkat, 293T, HepG2, Mouse kidney, rat ovary, rat thymus; Cellular Location: Cell membrane, Cytoplasm, Endoplasmic reticulum membrane, Mitochondrion, Nucleus
Immunogen sequence: LYFVLDYING GELFYHLQRE RCFLEPRARF YAAEIASALG YLHSLNIVYR DLKPENILLD SQGHIVLTDF GLCKENIEHN STTSTFCGTP EYLAPEVLHK QPYDRTVDWW CLGAVLYEML YGLPPFYSRN TAEMYDNILN KPLQLKPNIT NSARHLLEGL LQKDRTKRLG AKDDFMEIKS HVFFSLINWD DLINKKITPP FNPNVSGPND LRHFDPEFTE EPVPNSIGKS PDSVLVTASV KEAAEAFLGF SYAPPTDSFL
Target Information
SGK (SGK1) is a serine/threonine kinase that may be a transcriptional target for p38/MAPK in hepatoma cells. SGK plays an important role in cellular stress response and cell survival. SGK1 is transcriptionally activated by numerous stimuli, including serum, glucocorticoids, osmotic stress, and hormones. It phosphorylates and negatively regulates pro-apoptotic FOXO3A. SGK1 is thought to play an essential function in nephropathy and cardiovascular development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: serine/threonine protein kinase SGK; Serine/threonine-protein kinase Sgk1; serum and glucocorticoid-dependent protein kinase; Serum/glucocorticoid-regulated kinase 1; Sgk1 variant i3
Gene Aliases: SGK; SGK1
UniProt ID: (Human) O00141, (Mouse) Q9WVC6
Entrez Gene ID: (Human) 6446, (Mouse) 20393, (Rat) 29517
protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
calcium channel regulator activity
protein binding
ATP binding
potassium channel regulator activity
sodium channel regulator activity
chloride channel regulator activity
3-phosphoinositide-dependent protein kinase binding
cofactor binding
tau protein binding
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
phosphatidylinositol binding
protein modifying enzyme
regulation of cell growth
protein phosphorylation
sodium ion transport
cellular sodium ion homeostasis
apoptotic process
response to stress
cellular response to DNA damage stimulus
microtubule depolymerization
long-term memory
regulation of blood pressure
visual learning
positive regulation of sodium ion transport
peptidyl-serine phosphorylation
positive regulation of cell growth
regulation of cell migration
negative regulation of microtubule polymerization
positive regulation of transporter activity
ion transmembrane transport
intracellular signal transduction
regulation of cell proliferation
regulation of apoptotic process
negative regulation of apoptotic process
glucocorticoid mediated signaling pathway
neuron projection morphogenesis
positive regulation of dendrite morphogenesis
regulation of catalytic activity
regulation of sequence-specific DNA binding transcription factor activity
regulation of cell cycle
regulation of gastric acid secretion
renal sodium ion absorption
phosphorylation
cellular response to insulin stimulus
regulation of protein localization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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