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FIGURE: 1 / 1
SGK2 Antibody (PA5-88372) in WB
Western blot analysis of SGK2 in extracts of various cell lines. Samples were incubated with SGK2 Polyclonal antibody (Product # PA5-88372) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
Product Details
PA5-88372
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 228-367 of human SGK2 (NP_7337941)
Conjugate
Form
Liquid
Concentration
0.41 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2804865
Product Specific Information
Immunogen sequence: LHGLPPFYSQ DVSQMYENIL HQPLQIPGGR TVAACDLLQS LLHKDQRQRL GSKADFLEIK NHVFFSPINW DDLYHKRLTP PFNPNVTGPA DLKHFDPEFT QEAVSKSIGC TPDTVASSSG ASSAFLGFSY APEDDDILDC; Positive Samples: BxPC-3, 293T; Cellular Location: Cytoplasm, Nucleus
Target Information
SGK2 is a serine/threonine protein kinase which is similar to serum- and glucocorticoid-induced protein kinase (SGK). Unlike SGK, SGK2 is not induced by serum or glucocorticoids. It is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK. Although little is known about the transcriptional regulation of SGK2, the protein has been shown to be phosphorylated and activated by 3 phosphoinositide dependent protein kinase 1 (PDK1), and to a lesser extent insulin like growth factor 1, in vitro.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Serine/threonine-protein kinase Sgk2; serum/glucocorticoid regulated kinase 2; Serum/glucocorticoid-regulated kinase 2
Gene Aliases: dJ138B7.2; H-SGK2; SGK2
UniProt ID: (Human) Q9HBY8
Entrez Gene ID: (Human) 10110
regulation of cell growth
protein phosphorylation
cellular sodium ion homeostasis
response to oxidative stress
positive regulation of sodium ion transport
peptidyl-serine phosphorylation
positive regulation of transporter activity
ion transmembrane transport
intracellular signal transduction
regulation of cell proliferation
regulation of apoptotic process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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