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Invitrogen
SGOL1 Polyclonal Antibody
Advanced Verification
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 1
SGOL1 Antibody (PA5-84828)
Relative expression in different tissues in IHC: Detection of differential expression levels of SGOL1 demonstrates antibody specificity. Immunohistochemical analysis of SGOL1 using anti-SGOL1 Polyclonal Antibody (Product #PA5-84828), shows significant staining of SGOL1 in testis and shows minimal or weak staining in endometrium tissues. The relative expression levels of SGOL1 within each tissue is shown us... View More
Product Details
PA5-84828
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SGO1. Recombinant protein control fragment (Product #RP-105490).
Conjugate
Form
Liquid
Concentration
Lot-Specific
Purification
Anitgen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2791977
Product Specific Information
Immunogen sequence: TASVNYKEPT LASKLRRGDP FTDLCFLNSP IFKQKKDLRR SKKRALEVSP AKEAIFILYY VREFVSRFPD CRKCKLETH
Target Information
The protein encoded by this gene is a member of the shugoshin family of proteins. This protein is thought to protect centromeric cohesin from cleavage during mitotic prophase by preventing phosphorylation of a cohesin subunit. Reduced expression of this gene leads to the premature loss of centromeric cohesion, mis-segregation of sister chromatids, and mitotic arrest. Evidence suggests that this protein also protects a small subset of cohesin found along the length of the chromosome arms during mitotic prophase. An isoform lacking exon 6 has been shown to play a role in the cohesion of centrioles. Mutations in this gene have been associated with Chronic Atrial and Intestinal Dysrhythmia (CAID) syndrome, characterized by the co-occurrence of Sick Sinus Syndrome (SSS) and Chronic Intestinal Pseudo-obstruction (CIPO) within the first four decades of life. Fibroblast cells from CAID patients exhibited both increased cell proliferation and higher rates of senescence. Pseudogenes of this gene have been found on chromosomes 1 and 7. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hSgo1; Serologically defined breast cancer antigen NY-BR-85; Shugoshin 1; shugoshin 1AB protein; shugoshin 1CD protein; shugoshin 1EF protein; shugoshin 1GH protein; shugoshin 1KL protein; Shugoshin-like 1
Gene Aliases: CAID; NY-BR-85; SGO; SGO1; SGOL1
UniProt ID: (Human) Q5FBB7
Entrez Gene ID: (Human) 151648
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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