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Product Details
PA5-45795
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the C-terminal of human SGPL1
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2609909
Product Specific Information
Peptide sequence: IHFCITLLHA RKRVAIQFLK DIRESVTQIM KNPKAKTTGM GAIYGMAQTT
Sequence homology: Cow: 100%; Dog: 100%; Goat: 93%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 91%
Target Information
Sphingosine-1-phosphate lyase cleaves phosphorylated sphingoid bases, such as sphingosine-1 phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. The catalytic activity of sphingosine 1- phosphate lyase converts sphingosine 1-phosphate to phosphoethanolamine and palmitaldehyde using Pyridoxal phosphate as a co-factor. Sphingosine 1-phosphate lyase is a type III membrane protein found in the endoplasmic reticulum. Sphingosine 1-phosphate lyase is found primarily in the liver and kidney. Sphingosine 1-phosphate lyase belongs to the group II decarboxylase family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ13811; hSPL; S1PL; SP-lyase 1; Sphingosine-1-phosphate aldolase; Sphingosine-1-phosphate lyase 1; SPL 1
Gene Aliases: KIAA1252; S1PL; SGPL1; SPL
UniProt ID: (Human) O95470
Entrez Gene ID: (Human) 8879
luteinization
vasculogenesis
kidney development
fatty acid metabolic process
ceramide metabolic process
spermatogenesis
androgen metabolic process
estrogen metabolic process
post-embryonic development
fibroblast migration
hemopoiesis
sphingolipid biosynthetic process
sphingolipid catabolic process
Leydig cell differentiation
regulation of multicellular organism growth
platelet-derived growth factor receptor signaling pathway
skeletal system morphogenesis
palate development
face morphogenesis
apoptotic signaling pathway
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