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Product Details
PA5-90667
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 60-390 of human SGPL1 (NP_0038922)
Conjugate
Form
Liquid
Concentration
0.69 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2806168
Product Specific Information
Immunogen sequence: VFQPESLWSR FKKKCFKLTR KMPIIGRKIQ DKLNKTKDDI SKNMSFLKVD KEYVKALPSQ GLSSSAVLEK LKEYSSMDAF WQEGRASGTV YSGEEKLTEL LVKAYGDFAW SNPLHPDIFP GLRKIEAEIV RIACSLFNGG PDSCGCVTSG GTESILMACK AYRDLAFEKG IKTPEIVAPQ SAHAAFNKAA SYFGMKIVRV PLTKMMEVDV RAMRRAISRN TAMLVCSTPQ FPHGVIDPVP EVAKLAVKYK IPLHVDACLG GFLIVFMEKA GYPLEHPFDF RVKGVTSISA DTHKYGYAPK GSSLVLYSDK KYRNYQFFVD TDWQGGIYAS P; Positive Samples: U-87MG, LO2, 293T, A-431, Mouse liver, Mouse kidnay, Mouse lung, Rat brain ; Cellular Location: Endoplasmic reticulum membrane, Single-pass type III membrane protein
Target Information
Sphingosine-1-phosphate lyase cleaves phosphorylated sphingoid bases, such as sphingosine-1 phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. The catalytic activity of sphingosine 1- phosphate lyase converts sphingosine 1-phosphate to phosphoethanolamine and palmitaldehyde using Pyridoxal phosphate as a co-factor. Sphingosine 1-phosphate lyase is a type III membrane protein found in the endoplasmic reticulum. Sphingosine 1-phosphate lyase is found primarily in the liver and kidney. Sphingosine 1-phosphate lyase belongs to the group II decarboxylase family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ13811; hSPL; mSPL; S1PL; SP-lyase 1; sphingosine phosphate lyase 1; Sphingosine-1-phosphate aldolase; Sphingosine-1-phosphate lyase 1; SPL 1
Gene Aliases: AI428538; D10Xrf456; KIAA1252; S1PL; SGPL1; Spgl1; SPL
UniProt ID: (Human) O95470, (Mouse) Q8R0X7, (Rat) Q8CHN6
Entrez Gene ID: (Human) 8879, (Mouse) 20397, (Rat) 286896
luteinization
vasculogenesis
kidney development
fatty acid metabolic process
ceramide metabolic process
spermatogenesis
androgen metabolic process
estrogen metabolic process
post-embryonic development
fibroblast migration
hemopoiesis
sphingolipid biosynthetic process
sphingolipid catabolic process
Leydig cell differentiation
regulation of multicellular organism growth
platelet-derived growth factor receptor signaling pathway
skeletal system morphogenesis
palate development
face morphogenesis
apoptotic signaling pathway
lipid metabolic process
sphingolipid metabolic process
nitrogen compound metabolic process
apoptotic process
female gonad development
carboxylic acid metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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