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Immunogen sequence: MNGPALQPS SPSSAPSASP AAAPRGWSEF CELHAVAAAR ELARQYWLFA REHPQHAPLR AELVSLQFTD LFQRYFCREV RDGRAPGRDY RDTGRGPPAK AEASPEPGPG PAAPGLPKAR SSEELAPPRP PGPCSFQHFR RSLRHIFRRR SAGELPAAHT AAAPGTPGEA AETPARPGLA KKFLPWSLAR EPPPEALKEA VLRYSLADEA SMDSGARWQR GRLALRRAPG PDGPDRVLEL FDPPKSSRPK LQAACSSIQE VRWCTRLEMP DNLYTFVLKV KDRTDIIFEV GDEQQLNSWM AELSECTGRG LESTEAEMHI PSALEPSTSS SPRGSTDSLN Q (1-340 aa encoded by BC136451)
This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Lymphocyte adapter protein; Lymphocyte-specific adapter protein Lnk; SH2B adapter protein 3; Signal transduction protein Lnk
Gene Aliases: IDDM20; LNK; SH2B3
UniProt ID: (Human) Q9UQQ2
Entrez Gene ID: (Human) 10019
Molecular Function:
scaffold/adaptor protein
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