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This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus.
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Protein Aliases: Lymphocyte adapter protein; Lymphocyte-specific adapter protein Lnk; SH2B adapter protein 3; Signal transduction protein Lnk
Gene Aliases: IDDM20; LNK; SH2B3
UniProt ID: (Human) Q9UQQ2
Entrez Gene ID: (Human) 10019
Molecular Function:
scaffold/adaptor protein
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