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Lad (TSAD, TSAd, F2771, SH2D2A, SH2 domain protein 2A) is a 52 kDa cytoplasmic adapter protein that undergoes tyrosine-phosphorylation and influences T cell activation. Lad (SH2D2A) mRNA is present in peripheral blood leukocytes, thymus and spleen, and accumulates in the cytoplasm during T cell activation. The Lad gene maps to chromosome 1q21 in a region where alterations are characteristic to lymphomas.
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Protein Aliases: SH2 domain protein 2A; SH2 domain-containing adapter protein; SH2 domain-containing protein 2A; SH22A; T cell specific adapter protein TSAd; T cell-specific adapter protein; T lymphocyte specific adaptor protein; TSAd; VEGF receptor-associated protein
Gene Aliases: F2771; SCAP; SH2D2A; TSAD; VRAP
UniProt ID: (Human) Q9NP31
Entrez Gene ID: (Human) 9047
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