Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
This target displays homology in the following species: Cow: 93%; Dog: 93%; Goat: 80%; Guinea Pig: 100%; Horse: 79%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
This gene encodes an adapter protein that contains three N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The encoded protein facilitates protein-protein interactions and has been implicated in numerous cellular processes including apoptosis, cytoskeletal rearrangement, cell adhesion and in the regulation of clathrin-dependent endocytosis. Alternate splicing results in multiple transcript variants.
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Protein Aliases: Regulator of ubiquitous kinase; Ruk; SH3 domain-containing adapter protein; SH3 domain-containing kinase-binding protein 1; SH3-containing, expressed in tumorigenic astrocytes
Gene Aliases: Ruk; Seta; Sh3kbp1
UniProt ID: (Rat) Q925Q9
Entrez Gene ID: (Rat) 84357
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