Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Peptide sequence: LLKLLSGAST KRKPRVSPPA SPTLEVELGS AELPLQGAVG PELPPGGGHG
Sequence homology: Cow: 93%; Dog: 93%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: E3 ubiquitin-protein ligase SH3RF1; FLJ21602; plenty of SH3 domains; Plenty of SH3s; Protein POSH; putative E3 ubiquitin-protein ligase SH3RF1; RING finger protein 142; RING-type E3 ubiquitin transferase SH3RF1; SH3 domain-containing RING finger protein 1; SH3 multiple domains 2; SH3 multiple domains protein 2
Gene Aliases: KIAA1494; POSH; POSH1; RNF142; SH3MD2; SH3RF1
UniProt ID: (Human) Q7Z6J0
Entrez Gene ID: (Human) 57630
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