Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
FIGURE: 1 / 1
SHANK2 Antibody (MA5-24331) in IHC (P)
Immunohistochemical analysis of SHANK2 in immersion fixed paraffin-embedded sections of human brain (cerebellum). Samples were incubated in SHANK2 monoclonal antibody (Product # MA5-24331) using a dilution of 15 µg/mL overnight at 4 °C. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic . Tissue was stained using the Anti... View More
Product Details
MA5-24331
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
711924
Immunogen
E. coli-derived recombinant human SHANK2 Lys849-Thr1029
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2576486
Product Specific Information
Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.
Target Information
This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density of excitatory synapses. Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, and an SH3 domain. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the postsynaptic densities of the adult and developing brain. Alterations in the encoded protein may be associated with susceptibility to autism spectrum disorder. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: cortactin SH3 domain-binding protein; Cortactin-binding protein 1; CortBP1; CORTBP1CTTNBP1; GKAP/SAPAP interacting protein; proline-rich synapse associated protein 1; Proline-rich synapse-associated protein 1; SH3 and multiple ankyrin repeat domains protein 2; Shank2
Gene Aliases: AUTS17; CORTBP1; CTTNBP1; KIAA1022; PROSAP1; SHANK; SHANK2; SPANK-3
UniProt ID: (Human) Q9UPX8
Entrez Gene ID: (Human) 22941
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support