Product References
Characterization of SHARPIN knockout Syrian hamsters developed using CRISPR/Cas9 system.
Animal models and experimental medicine
Miao J,Lan T,Guo H,Wang J,Zhang G,Wang Z,Yang P,Li H,Zhang C,Wang Y,Li XM,Miao M
Sun Oct 01 00:00:00 EDT 2023
SPATA2 restricts OTULIN-dependent LUBAC activity independently of CYLD.
Cell reports
Griewahn L,Müller-Foxworth M,Peintner L,Wissler M,Weiss M,Brauns-Schubert P,Massoumi R,Borner C,Groß O,Yabal M,Charvet C,Maurer U
Tue Jan 31 00:00:00 EST 2023
Linear ubiquitination improves NFAT1 protein stability and facilitates NFAT1 signalling in Kawasaki disease.
The FEBS journal
Miao Y,Qian G,Zhang R,Yuan Y,Zuo Y,Ding Y,Li X,Tang Y,Zheng H,Lv H
Fri Sep 01 00:00:00 EDT 2023
Linear ubiquitination improves NFAT1 protein stability and facilitates NFAT1 signalling in Kawasaki disease.
The FEBS journal
Miao Y,Qian G,Zhang R,Yuan Y,Zuo Y,Ding Y,Li X,Tang Y,Zheng H,Lv H
Fri Sep 01 00:00:00 EDT 2023
Linear ubiquitination improves NFAT1 protein stability and facilitates NFAT1 signalling in Kawasaki disease.
The FEBS journal
Miao Y,Qian G,Zhang R,Yuan Y,Zuo Y,Ding Y,Li X,Tang Y,Zheng H,Lv H
Fri Sep 01 00:00:00 EDT 2023
Linear ubiquitination improves NFAT1 protein stability and facilitates NFAT1 signalling in Kawasaki disease.
The FEBS journal
Miao Y,Qian G,Zhang R,Yuan Y,Zuo Y,Ding Y,Li X,Tang Y,Zheng H,Lv H
Fri Sep 01 00:00:00 EDT 2023
Linear ubiquitination modification of NR6A1 by LUBAC inhibits RIPK3 kinase activity and attenuates apoptosis of vascular smooth muscle cells.
Journal of biochemical and molecular toxicology
Cai Z,He X,Liu S,Bai Y,Pan B,Wu K
Mon Aug 01 00:00:00 EDT 2022
The FDA-approved drug Auranofin has a dual inhibitory effect on SARS-CoV-2 entry and NF-κB signaling.
iScience
Laplantine E,Chable-Bessia C,Oudin A,Swain J,Soria A,Merida P,Gourdelier M,Mestiri S,Besseghe I,Bremaud E,Neyret A,Lyonnais S,Favard C,Benaroch P,Hubert M,Schwartz O,Guerin M,Danckaert A,Del Nery E,Muriaux D,Weil R
Fri Oct 21 00:00:00 EDT 2022
A20 controls RANK-dependent osteoclast formation and bone physiology.
EMBO reports
Martens A,Hertens P,Priem D,Rinotas V,Meletakos T,Gennadi M,Van Hove L,Louagie E,Coudenys J,De Muynck A,Gaublomme D,Sze M,van Hengel J,Catrysse L,Hoste E,Zajac JD,Davey RA,Van Hoorebeke L,Hochepied T,Bertrand MJM,Armaka M,Elewaut D,van Loo G
Tue Dec 06 00:00:00 EST 2022
HOIP modulates the stability of GPx4 by linear ubiquitination.
Proceedings of the National Academy of Sciences of the United States of America
Dong K,Wei R,Jin T,Zhang M,Shen J,Xiang H,Shan B,Yuan J,Li Y
Tue Nov 01 00:00:00 EDT 2022
Ubiquitin-binding domain in ABIN1 is critical for regulating cell death and inflammation during development.
Cell death and differentiation
Li M,Liu Y,Xu C,Zhao Q,Liu J,Xing M,Li X,Zhang H,Wu X,Wang L,Ou Y,Wu X,Zhao X,Liu H,Qiu L,Li F,Li J,Rong W,Luo Y,Deng J,Wang X,Wang Z,Zhao Y,Lv A,Li Q,Zhang H
Sat Oct 01 00:00:00 EDT 2022
Compound heterozygous variants in OTULIN are associated with fulminant atypical late-onset ORAS.
EMBO molecular medicine
Zinngrebe J,Moepps B,Monecke T,Gierschik P,Schlichtig F,Barth TFE,Strauß G,Boldrin E,Posovszky C,Schulz A,Beringer O,Rieser E,Jacobsen EM,Lorenz MR,Schwarz K,Pannicke U,Walczak H,Niessing D,Schuetz C,Fischer-Posovszky P,Debatin KM
Mon Mar 07 00:00:00 EST 2022
Human ZBP1 induces cell death-independent inflammatory signaling via RIPK3 and RIPK1.
EMBO reports
Peng R,Wang CK,Wang-Kan X,Idorn M,Kjaer M,Zhou FY,Fiil BK,Timmermann F,Orozco SL,McCarthy J,Leung CS,Lu X,Bagola K,Rehwinkel J,Oberst A,Maelfait J,Paludan SR,Gyrd-Hansen M
Tue Dec 06 00:00:00 EST 2022
Human ZBP1 induces cell death-independent inflammatory signaling via RIPK3 and RIPK1.
EMBO reports
Peng R,Wang CK,Wang-Kan X,Idorn M,Kjaer M,Zhou FY,Fiil BK,Timmermann F,Orozco SL,McCarthy J,Leung CS,Lu X,Bagola K,Rehwinkel J,Oberst A,Maelfait J,Paludan SR,Gyrd-Hansen M
Tue Dec 06 00:00:00 EST 2022
PP6 negatively modulates LUBAC-mediated M1-ubiquitination of RIPK1 and c-FLIPL to promote TNFα-mediated cell death.
Cell death & disease
Wu G,Li D,Liang W,Sun W,Xie X,Tong Y,Shan B,Zhang M,Lu X,Yuan J,Li Y
Wed Sep 07 00:00:00 EDT 2022
PP6 negatively modulates LUBAC-mediated M1-ubiquitination of RIPK1 and c-FLIPL to promote TNFα-mediated cell death.
Cell death & disease
Wu G,Li D,Liang W,Sun W,Xie X,Tong Y,Shan B,Zhang M,Lu X,Yuan J,Li Y
Wed Sep 07 00:00:00 EDT 2022
SHARPIN S146 phosphorylation mediates ARP2/3 interaction, cancer cell invasion and metastasis.
Journal of cell science
Butt U,Khan MH,Pouwels J,Westermarck J
Sat Oct 15 00:00:00 EDT 2022
SENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation.
Nature communications
Yan L,Zhang T,Wang K,Chen Z,Yang Y,Shan B,Sun Q,Zhang M,Zhang Y,Zhong Y,Liu N,Gu J,Xu D
Tue Nov 22 00:00:00 EST 2022
Linear ubiquitination of PTEN impairs its function to promote prostate cancer progression.
Oncogene
Guo Y,He J,Zhang H,Chen R,Li L,Liu X,Huang C,Qiang Z,Zhou Z,Wang Y,Huang J,Zhao X,Zheng J,Chen GQ,Yu J
Sat Oct 01 00:00:00 EDT 2022
Linear ubiquitination of PTEN impairs its function to promote prostate cancer progression.
Oncogene
Guo Y,He J,Zhang H,Chen R,Li L,Liu X,Huang C,Qiang Z,Zhou Z,Wang Y,Huang J,Zhao X,Zheng J,Chen GQ,Yu J
Sat Oct 01 00:00:00 EDT 2022
Identification and molecular analysis of RNF31 Q622H germline polymorphism.
Oncology letters
Nakazawa S,Mamiya R,Kawabata-Iwakawa R,Oikawa D,Kaira K,Tokunaga F,Nobusawa S,Sato Y,Sasaki A,Yajima T,Shirabe K
Tue Nov 01 00:00:00 EDT 2022
Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death.
Cell
Taft J,Markson M,Legarda D,Patel R,Chan M,Malle L,Richardson A,Gruber C,Martín-Fernández M,Mancini GMS,van Laar JAM,van Pelt P,Buta S,Wokke BHA,Sabli IKD,Sancho-Shimizu V,Chavan PP,Schnappauf O,Khubchandani R,Cüceoğlu MK,Özen S,Kastner DL,Ting AT,Aksentijevich I,Hollink IHIM,Bogunovic D
Thu Aug 19 00:00:00 EDT 2021
Regulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains.
Cell reports
Elliott PR,Leske D,Wagstaff J,Schlicher L,Berridge G,Maslen S,Timmermann F,Ma B,Fischer R,Freund SMV,Komander D,Gyrd-Hansen M
Tue Oct 05 00:00:00 EDT 2021
Hypoxia regulates overall mRNA homeostasis by inducing Met1-linked linear ubiquitination of AGO2 in cancer cells.
Nature communications
Zhang H,Zhao X,Guo Y,Chen R,He J,Li L,Qiang Z,Yang Q,Liu X,Huang C,Lu R,Fang J,Cao Y,Huang J,Wang Y,Huang J,Chen GQ,Cheng J,Yu J
Mon Sep 13 00:00:00 EDT 2021
OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin.
Molecular cell
Fu Y,Wang H,Dai H,Zhu Q,Cui CP,Sun X,Li Y,Deng Z,Zhou X,Ge Y,Peng Z,Yuan C,Wu B,Yang X,Li R,Liu CH,He F,Wei W,Zhang L
Thu Aug 05 00:00:00 EDT 2021
SHARPIN regulates the development of clear cell renal cell carcinoma by promoting von Hippel-Lindau protein ubiquitination and degradation.
Cancer science
Yin R,Liu S
Fri Oct 01 00:00:00 EDT 2021
SHARPIN regulates the development of clear cell renal cell carcinoma by promoting von Hippel-Lindau protein ubiquitination and degradation.
Cancer science
Yin R,Liu S
Fri Oct 01 00:00:00 EDT 2021
SHARPIN regulates the development of clear cell renal cell carcinoma by promoting von Hippel-Lindau protein ubiquitination and degradation.
Cancer science
Yin R,Liu S
Fri Oct 01 00:00:00 EDT 2021
T cell-derived tumor necrosis factor induces cytotoxicity by activating RIPK1-dependent target cell death.
JCI insight
Chun N,Ang RL,Chan M,Fairchild RL,Baldwin WM,Horwitz JK,Gelles JD,Chipuk JE,Kelliher MA,Pavlov VI,Li Y,Homann D,Heeger PS,Ting AT
Wed Dec 22 00:00:00 EST 2021
SHARPIN stabilizes β-catenin through a linear ubiquitination-independent manner to support gastric tumorigenesis.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
Zhang L,Liu Q,Liu KW,Qin ZY,Zhu GX,Shen LT,Zhang N,Liu BY,Che LR,Li JY,Wang T,Wen LZ,Liu KJ,Guo Y,Yin XR,Wang XW,Zhou ZH,Xiao HL,Cui YH,Bian XW,Lan CH,Chen D,Wang B
Mon Mar 01 00:00:00 EST 2021
Impaired RIPK1 ubiquitination sensitizes mice to TNF toxicity and inflammatory cell death.
Cell death and differentiation
Kist M,Kőműves LG,Goncharov T,Dugger DL,Yu C,Roose-Girma M,Newton K,Webster JD,Vucic D
Mon Mar 01 00:00:00 EST 2021
Impaired RIPK1 ubiquitination sensitizes mice to TNF toxicity and inflammatory cell death.
Cell death and differentiation
Kist M,Kőműves LG,Goncharov T,Dugger DL,Yu C,Roose-Girma M,Newton K,Webster JD,Vucic D
Mon Mar 01 00:00:00 EST 2021
Primidone blocks RIPK1-driven cell death and inflammation.
Cell death and differentiation
Riebeling T,Jamal K,Wilson R,Kolbrink B,von Samson-Himmelstjerna FA,Moerke C,Ramos Garcia L,Dahlke E,Michels F,Lühder F,Schunk D,Doldi P,Tyczynski B,Kribben A,Flüh C,Theilig F,Kunzendorf U,Meier P,Krautwald S
Sat May 01 00:00:00 EDT 2021
OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity.
Nature communications
Hoste E,Lecomte K,Annusver K,Vandamme N,Roels J,Maschalidi S,Verboom L,Vikkula HK,Sze M,Van Hove L,Verstaen K,Martens A,Hochepied T,Saeys Y,Ravichandran K,Kasper M,van Loo G
Fri Oct 08 00:00:00 EDT 2021
A unique death pathway keeps RIPK1 D325A mutant mice in check at embryonic day 10.5.
PLoS biology
Zhang Y,Huang K,Zhang Y,Han T,Li L,Ruan C,Sun YH,Shi W,Han W,Wu SQ,Song J,Liu J,Han J
Sun Aug 01 00:00:00 EDT 2021
Crosstalk Between NDP52 and LUBAC in Innate Immune Responses, Cell Death, and Xenophagy.
Frontiers in immunology
Miyashita H,Oikawa D,Terawaki S,Kabata D,Shintani A,Tokunaga F
Tue Sep 21 00:00:00 EDT 2021
Systematic analysis of the IL-17 receptor signalosome reveals a robust regulatory feedback loop.
The EMBO journal
Draberova H,Janusova S,Knizkova D,Semberova T,Pribikova M,Ujevic A,Harant K,Knapkova S,Hrdinka M,Fanfani V,Stracquadanio G,Drobek A,Ruppova K,Stepanek O,Draber P
Tue Sep 01 00:00:00 EDT 2020
The parkin-coregulated gene product PACRG promotes TNF signaling by stabilizing LUBAC.
Science signaling
Meschede J,Šadić M,Furthmann N,Miedema T,Sehr DA,Müller-Rischart AK,Bader V,Berlemann LA,Pilsl A,Schlierf A,Barkovits K,Kachholz B,Rittinger K,Ikeda F,Marcus K,Schaefer L,Tatzelt J,Winklhofer KF
Tue Feb 04 00:00:00 EST 2020
Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses.
Communications biology
Oikawa D,Sato Y,Ohtake F,Komakura K,Hanada K,Sugawara K,Terawaki S,Mizukami Y,Phuong HT,Iio K,Obika S,Fukushi M,Irie T,Tsuruta D,Sakamoto S,Tanaka K,Saeki Y,Fukai S,Tokunaga F
Fri Apr 03 00:00:00 EDT 2020
Cross-regulation between LUBAC and caspase-1 modulates cell death and inflammation.
The Journal of biological chemistry
Douglas T,Saleh M
Fri Apr 17 00:00:00 EDT 2020
Subquinocin, a small molecule inhibitor of CYLD and USP-family deubiquitinating enzymes, promotes NF-κB signaling.
Biochemical and biophysical research communications
Yamanaka S,Sato Y,Oikawa D,Goto E,Fukai S,Tokunaga F,Takahashi H,Sawasaki T
Thu Mar 26 00:00:00 EDT 2020
OTULIN Prevents Liver Inflammation and Hepatocellular Carcinoma by Inhibiting FADD- and RIPK1 Kinase-Mediated Hepatocyte Apoptosis.
Cell reports
Verboom L,Martens A,Priem D,Hoste E,Sze M,Vikkula H,Van Hove L,Voet S,Roels J,Maelfait J,Bongiovanni L,de Bruin A,Scott CL,Saeys Y,Pasparakis M,Bertrand MJM,van Loo G
Tue Feb 18 00:00:00 EST 2020
Ubiquitination of RIPK1 regulates its activation mediated by TNFR1 and TLRs signaling in distinct manners.
Nature communications
Li X,Zhang M,Huang X,Liang W,Li G,Lu X,Li Y,Pan H,Shi L,Zhu H,Qian L,Shan B,Yuan J
Fri Dec 11 00:00:00 EST 2020
Cellular and Mathematical Analyses of LUBAC Involvement in T Cell Receptor-Mediated NF-κB Activation Pathway.
Frontiers in immunology
Oikawa D,Hatanaka N,Suzuki T,Tokunaga F
Mon Jun 21 00:00:00 EDT 2021
RIPK1-mediated immunogenic cell death promotes anti-tumour immunity against soft-tissue sarcoma.
EMBO molecular medicine
Smith HG,Jamal K,Dayal JH,Tenev T,Kyula-Currie J,Guppy N,Gazinska P,Roulstone V,Liccardi G,Davies E,Roxanis I,Melcher AA,Hayes AJ,Inman GJ,Harrington KJ,Meier P
Mon Jun 08 00:00:00 EDT 2020
MST1 Negatively Regulates TNFα-Induced NF-κB Signaling through Modulating LUBAC Activity.
Molecular cell
Lee IY,Lim JM,Cho H,Kim E,Kim Y,Oh HK,Yang WS,Roh KH,Park HW,Mo JS,Yoon JH,Song HK,Choi EJ
Thu Mar 21 00:00:00 EDT 2019
The anticonvulsive Phenhydan® suppresses extrinsic cell death.
Cell death and differentiation
Moerke C,Jaco I,Dewitz C,Müller T,Jacobsen AV,Gautheron J,Fritsch J,Schmitz J,Bräsen JH,Günther C,Murphy JM,Kunzendorf U,Meier P,Krautwald S
Sun Sep 01 00:00:00 EDT 2019
The anticonvulsive Phenhydan® suppresses extrinsic cell death.
Cell death and differentiation
Moerke C,Jaco I,Dewitz C,Müller T,Jacobsen AV,Gautheron J,Fritsch J,Schmitz J,Bräsen JH,Günther C,Murphy JM,Kunzendorf U,Meier P,Krautwald S
Sun Sep 01 00:00:00 EDT 2019
Post-translational Modification of OTULIN Regulates Ubiquitin Dynamics and Cell Death.
Cell reports
Douglas T,Saleh M
Tue Dec 10 00:00:00 EST 2019
A novel inhibitor of nuclear factor kappa-B kinase subunit gamma mutation identified in an incontinentia pigmenti patient with syndromic tooth agenesis.
Archives of oral biology
Sun S,Li F,Liu Y,Qu H,Wong SW,Zeng L,Yu M,Feng H,Liu H,Han D
Wed May 01 00:00:00 EDT 2019
Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation.
Nature communications
Dondelinger Y,Delanghe T,Priem D,Wynosky-Dolfi MA,Sorobetea D,Rojas-Rivera D,Giansanti P,Roelandt R,Gropengiesser J,Ruckdeschel K,Savvides SN,Heck AJR,Vandenabeele P,Brodsky IE,Bertrand MJM
Mon Apr 15 00:00:00 EDT 2019
OTULIN limits cell death and inflammation by deubiquitinating LUBAC.
Nature
Heger K,Wickliffe KE,Ndoja A,Zhang J,Murthy A,Dugger DL,Maltzman A,de Sousa E Melo F,Hung J,Zeng Y,Verschueren E,Kirkpatrick DS,Vucic D,Lee WP,Roose-Girma M,Newman RJ,Warming S,Hsiao YC,Kőműves LG,Webster JD,Newton K,Dixit VM
Sun Jul 01 00:00:00 EDT 2018
OTULIN limits cell death and inflammation by deubiquitinating LUBAC.
Nature
Heger K,Wickliffe KE,Ndoja A,Zhang J,Murthy A,Dugger DL,Maltzman A,de Sousa E Melo F,Hung J,Zeng Y,Verschueren E,Kirkpatrick DS,Vucic D,Lee WP,Roose-Girma M,Newman RJ,Warming S,Hsiao YC,Kőműves LG,Webster JD,Newton K,Dixit VM
Sun Jul 01 00:00:00 EDT 2018
LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis.
Nature
Peltzer N,Darding M,Montinaro A,Draber P,Draberova H,Kupka S,Rieser E,Fisher A,Hutchinson C,Taraborrelli L,Hartwig T,Lafont E,Haas TL,Shimizu Y,Böiers C,Sarr A,Rickard J,Alvarez-Diaz S,Ashworth MT,Beal A,Enver T,Bertin J,Kaiser W,Strasser A,Silke J,Bouillet P,Walczak H
Tue May 01 00:00:00 EDT 2018
LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis.
Nature
Peltzer N,Darding M,Montinaro A,Draber P,Draberova H,Kupka S,Rieser E,Fisher A,Hutchinson C,Taraborrelli L,Hartwig T,Lafont E,Haas TL,Shimizu Y,Böiers C,Sarr A,Rickard J,Alvarez-Diaz S,Ashworth MT,Beal A,Enver T,Bertin J,Kaiser W,Strasser A,Silke J,Bouillet P,Walczak H
Tue May 01 00:00:00 EDT 2018
LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis.
Nature
Peltzer N,Darding M,Montinaro A,Draber P,Draberova H,Kupka S,Rieser E,Fisher A,Hutchinson C,Taraborrelli L,Hartwig T,Lafont E,Haas TL,Shimizu Y,Böiers C,Sarr A,Rickard J,Alvarez-Diaz S,Ashworth MT,Beal A,Enver T,Bertin J,Kaiser W,Strasser A,Silke J,Bouillet P,Walczak H
Tue May 01 00:00:00 EDT 2018
LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis.
Nature
Peltzer N,Darding M,Montinaro A,Draber P,Draberova H,Kupka S,Rieser E,Fisher A,Hutchinson C,Taraborrelli L,Hartwig T,Lafont E,Haas TL,Shimizu Y,Böiers C,Sarr A,Rickard J,Alvarez-Diaz S,Ashworth MT,Beal A,Enver T,Bertin J,Kaiser W,Strasser A,Silke J,Bouillet P,Walczak H
Tue May 01 00:00:00 EDT 2018
ABIN-1 regulates RIPK1 activation by linking Met1 ubiquitylation with Lys63 deubiquitylation in TNF-RSC.
Nature cell biology
Dziedzic SA,Su Z,Jean Barrett V,Najafov A,Mookhtiar AK,Amin P,Pan H,Sun L,Zhu H,Ma A,Abbott DW,Yuan J
Mon Jan 01 00:00:00 EST 2018
ABIN-1 regulates RIPK1 activation by linking Met1 ubiquitylation with Lys63 deubiquitylation in TNF-RSC.
Nature cell biology
Dziedzic SA,Su Z,Jean Barrett V,Najafov A,Mookhtiar AK,Amin P,Pan H,Sun L,Zhu H,Ma A,Abbott DW,Yuan J
Mon Jan 01 00:00:00 EST 2018
ABIN-1 regulates RIPK1 activation by linking Met1 ubiquitylation with Lys63 deubiquitylation in TNF-RSC.
Nature cell biology
Dziedzic SA,Su Z,Jean Barrett V,Najafov A,Mookhtiar AK,Amin P,Pan H,Sun L,Zhu H,Ma A,Abbott DW,Yuan J
Mon Jan 01 00:00:00 EST 2018
ABIN-1 regulates RIPK1 activation by linking Met1 ubiquitylation with Lys63 deubiquitylation in TNF-RSC.
Nature cell biology
Dziedzic SA,Su Z,Jean Barrett V,Najafov A,Mookhtiar AK,Amin P,Pan H,Sun L,Zhu H,Ma A,Abbott DW,Yuan J
Mon Jan 01 00:00:00 EST 2018
Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2.
Molecular cell
Annibaldi A,Wicky John S,Vanden Berghe T,Swatek KN,Ruan J,Liccardi G,Bianchi K,Elliott PR,Choi SM,Van Coillie S,Bertin J,Wu H,Komander D,Vandenabeele P,Silke J,Meier P
Thu Feb 15 00:00:00 EST 2018
Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2.
Molecular cell
Annibaldi A,Wicky John S,Vanden Berghe T,Swatek KN,Ruan J,Liccardi G,Bianchi K,Elliott PR,Choi SM,Van Coillie S,Bertin J,Wu H,Komander D,Vandenabeele P,Silke J,Meier P
Thu Feb 15 00:00:00 EST 2018
HOIL1 Is Essential for the Induction of Type I and III Interferons by MDA5 and Regulates Persistent Murine Norovirus Infection.
Journal of virology
MacDuff DA,Baldridge MT,Qaqish AM,Nice TJ,Darbandi AD,Hartley VL,Peterson ST,Miner JJ,Iwai K,Virgin HW
Sat Dec 01 00:00:00 EST 2018
HOIL1 Is Essential for the Induction of Type I and III Interferons by MDA5 and Regulates Persistent Murine Norovirus Infection.
Journal of virology
MacDuff DA,Baldridge MT,Qaqish AM,Nice TJ,Darbandi AD,Hartley VL,Peterson ST,Miner JJ,Iwai K,Virgin HW
Sat Dec 01 00:00:00 EST 2018
HOIL1 Is Essential for the Induction of Type I and III Interferons by MDA5 and Regulates Persistent Murine Norovirus Infection.
Journal of virology
MacDuff DA,Baldridge MT,Qaqish AM,Nice TJ,Darbandi AD,Hartley VL,Peterson ST,Miner JJ,Iwai K,Virgin HW
Sat Dec 01 00:00:00 EST 2018
LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L.
Nature communications
Taraborrelli L,Peltzer N,Montinaro A,Kupka S,Rieser E,Hartwig T,Sarr A,Darding M,Draber P,Haas TL,Akarca A,Marafioti T,Pasparakis M,Bertin J,Gough PJ,Bouillet P,Strasser A,Leverkus M,Silke J,Walczak H
Tue Sep 25 00:00:00 EDT 2018
LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L.
Nature communications
Taraborrelli L,Peltzer N,Montinaro A,Kupka S,Rieser E,Hartwig T,Sarr A,Darding M,Draber P,Haas TL,Akarca A,Marafioti T,Pasparakis M,Bertin J,Gough PJ,Bouillet P,Strasser A,Leverkus M,Silke J,Walczak H
Tue Sep 25 00:00:00 EDT 2018
Parkin regulates NF-κB by mediating site-specific ubiquitination of RIPK1.
Cell death & disease
Wang Y,Shan B,Liang Y,Wei H,Yuan J
Thu Jun 28 00:00:00 EDT 2018
Parkin regulates NF-κB by mediating site-specific ubiquitination of RIPK1.
Cell death & disease
Wang Y,Shan B,Liang Y,Wei H,Yuan J
Thu Jun 28 00:00:00 EDT 2018
A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development.
Cancer cell
Boege Y,Malehmir M,Healy ME,Bettermann K,Lorentzen A,Vucur M,Ahuja AK,Böhm F,Mertens JC,Shimizu Y,Frick L,Remouchamps C,Mutreja K,Kähne T,Sundaravinayagam D,Wolf MJ,Rehrauer H,Koppe C,Speicher T,Padrissa-Altés S,Maire R,Schattenberg JM,Jeong JS,Liu L,Zwirner S,Boger R,Hüser N,Davis RJ,Müllhaupt B,Moch H,Schulze-Bergkamen H,Clavien PA,Werner S,Borsig L,Luther SA,Jost PJ,Weinlich R,Unger K,Behrens A,Hillert L,Dillon C,Di Virgilio M,Wallach D,Dejardin E,Zender L,Naumann M,Walczak H,Green DR,Lopes M,Lavrik I,Luedde T,Heikenwalder M,Weber A
Mon Sep 11 00:00:00 EDT 2017
A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development.
Cancer cell
Boege Y,Malehmir M,Healy ME,Bettermann K,Lorentzen A,Vucur M,Ahuja AK,Böhm F,Mertens JC,Shimizu Y,Frick L,Remouchamps C,Mutreja K,Kähne T,Sundaravinayagam D,Wolf MJ,Rehrauer H,Koppe C,Speicher T,Padrissa-Altés S,Maire R,Schattenberg JM,Jeong JS,Liu L,Zwirner S,Boger R,Hüser N,Davis RJ,Müllhaupt B,Moch H,Schulze-Bergkamen H,Clavien PA,Werner S,Borsig L,Luther SA,Jost PJ,Weinlich R,Unger K,Behrens A,Hillert L,Dillon C,Di Virgilio M,Wallach D,Dejardin E,Zender L,Naumann M,Walczak H,Green DR,Lopes M,Lavrik I,Luedde T,Heikenwalder M,Weber A
Mon Sep 11 00:00:00 EDT 2017
MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death.
Molecular cell
Jaco I,Annibaldi A,Lalaoui N,Wilson R,Tenev T,Laurien L,Kim C,Jamal K,Wicky John S,Liccardi G,Chau D,Murphy JM,Brumatti G,Feltham R,Pasparakis M,Silke J,Meier P
Thu Jun 01 00:00:00 EDT 2017
MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death.
Molecular cell
Jaco I,Annibaldi A,Lalaoui N,Wilson R,Tenev T,Laurien L,Kim C,Jamal K,Wicky John S,Liccardi G,Chau D,Murphy JM,Brumatti G,Feltham R,Pasparakis M,Silke J,Meier P
Thu Jun 01 00:00:00 EDT 2017
SHARPIN regulates collagen architecture and ductal outgrowth in the developing mouse mammary gland.
The EMBO journal
Peuhu E,Kaukonen R,Lerche M,Saari M,Guzmán C,Rantakari P,De Franceschi N,Wärri A,Georgiadou M,Jacquemet G,Mattila E,Virtakoivu R,Liu Y,Attieh Y,Silva KA,Betz T,Sundberg JP,Salmi M,Deugnier MA,Eliceiri KW,Ivaska J
Tue Jan 17 00:00:00 EST 2017
SHARPIN regulates collagen architecture and ductal outgrowth in the developing mouse mammary gland.
The EMBO journal
Peuhu E,Kaukonen R,Lerche M,Saari M,Guzmán C,Rantakari P,De Franceschi N,Wärri A,Georgiadou M,Jacquemet G,Mattila E,Virtakoivu R,Liu Y,Attieh Y,Silva KA,Betz T,Sundberg JP,Salmi M,Deugnier MA,Eliceiri KW,Ivaska J
Tue Jan 17 00:00:00 EST 2017
The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death.
The EMBO journal
Lafont E,Kantari-Mimoun C,Draber P,De Miguel D,Hartwig T,Reichert M,Kupka S,Shimizu Y,Taraborrelli L,Spit M,Sprick MR,Walczak H
Tue May 02 00:00:00 EDT 2017
The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death.
The EMBO journal
Lafont E,Kantari-Mimoun C,Draber P,De Miguel D,Hartwig T,Reichert M,Kupka S,Shimizu Y,Taraborrelli L,Spit M,Sprick MR,Walczak H
Tue May 02 00:00:00 EDT 2017
SPATA2 regulates the activation of RIPK1 by modulating linear ubiquitination.
Genes & development
Wei R,Xu LW,Liu J,Li Y,Zhang P,Shan B,Lu X,Qian L,Wu Z,Dong K,Zhu H,Pan L,Yuan J,Pan H
Thu Jun 01 00:00:00 EDT 2017
SPATA2 regulates the activation of RIPK1 by modulating linear ubiquitination.
Genes & development
Wei R,Xu LW,Liu J,Li Y,Zhang P,Shan B,Lu X,Qian L,Wu Z,Dong K,Zhu H,Pan L,Yuan J,Pan H
Thu Jun 01 00:00:00 EDT 2017
Roles of the TRAF6 and Pellino E3 ligases in MyD88 and RANKL signaling.
Proceedings of the National Academy of Sciences of the United States of America
Strickson S,Emmerich CH,Goh ETH,Zhang J,Kelsall IR,Macartney T,Hastie CJ,Knebel A,Peggie M,Marchesi F,Arthur JSC,Cohen P
Tue Apr 25 00:00:00 EDT 2017
Roles of the TRAF6 and Pellino E3 ligases in MyD88 and RANKL signaling.
Proceedings of the National Academy of Sciences of the United States of America
Strickson S,Emmerich CH,Goh ETH,Zhang J,Kelsall IR,Macartney T,Hastie CJ,Knebel A,Peggie M,Marchesi F,Arthur JSC,Cohen P
Tue Apr 25 00:00:00 EDT 2017
HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63- and Met1-Linked Hybrid Polyubiquitin Chains.
PLoS pathogens
Shibata Y,Tokunaga F,Goto E,Komatsu G,Gohda J,Saeki Y,Tanaka K,Takahashi H,Sawasaki T,Inoue S,Oshiumi H,Seya T,Nakano H,Tanaka Y,Iwai K,Inoue JI
Sun Jan 01 00:00:00 EST 2017
HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63- and Met1-Linked Hybrid Polyubiquitin Chains.
PLoS pathogens
Shibata Y,Tokunaga F,Goto E,Komatsu G,Gohda J,Saeki Y,Tanaka K,Takahashi H,Sawasaki T,Inoue S,Oshiumi H,Seya T,Nakano H,Tanaka Y,Iwai K,Inoue JI
Sun Jan 01 00:00:00 EST 2017
The Sharpin interactome reveals a role for Sharpin in lamellipodium formation via the Arp2/3 complex.
Journal of cell science
Khan MH,Salomaa SI,Jacquemet G,Butt U,Miihkinen M,Deguchi T,Kremneva E,Lappalainen P,Humphries MJ,Pouwels J
Fri Sep 15 00:00:00 EDT 2017
The Sharpin interactome reveals a role for Sharpin in lamellipodium formation via the Arp2/3 complex.
Journal of cell science
Khan MH,Salomaa SI,Jacquemet G,Butt U,Miihkinen M,Deguchi T,Kremneva E,Lappalainen P,Humphries MJ,Pouwels J
Fri Sep 15 00:00:00 EDT 2017
The Sharpin interactome reveals a role for Sharpin in lamellipodium formation via the Arp2/3 complex.
Journal of cell science
Khan MH,Salomaa SI,Jacquemet G,Butt U,Miihkinen M,Deguchi T,Kremneva E,Lappalainen P,Humphries MJ,Pouwels J
Fri Sep 15 00:00:00 EDT 2017
The Sharpin interactome reveals a role for Sharpin in lamellipodium formation via the Arp2/3 complex.
Journal of cell science
Khan MH,Salomaa SI,Jacquemet G,Butt U,Miihkinen M,Deguchi T,Kremneva E,Lappalainen P,Humphries MJ,Pouwels J
Fri Sep 15 00:00:00 EDT 2017
Decreased linear ubiquitination of NEMO and FADD on apoptosis with caspase-mediated cleavage of HOIP.
Biochemical and biophysical research communications
Goto E,Tokunaga F
Sat Mar 25 00:00:00 EDT 2017
Decreased linear ubiquitination of NEMO and FADD on apoptosis with caspase-mediated cleavage of HOIP.
Biochemical and biophysical research communications
Goto E,Tokunaga F
Sat Mar 25 00:00:00 EDT 2017
Lack of interaction between NEMO and SHARPIN impairs linear ubiquitination and NF-κB activation and leads to incontinentia pigmenti.
The Journal of allergy and clinical immunology
Bal E,Laplantine E,Hamel Y,Dubosclard V,Boisson B,Pescatore A,Picard C,Hadj-Rabia S,Royer G,Steffann J,Bonnefont JP,Ursini VM,Vabres P,Munnich A,Casanova JL,Bodemer C,Weil R,Agou F,Smahi A
Fri Dec 01 00:00:00 EST 2017
Lack of interaction between NEMO and SHARPIN impairs linear ubiquitination and NF-κB activation and leads to incontinentia pigmenti.
The Journal of allergy and clinical immunology
Bal E,Laplantine E,Hamel Y,Dubosclard V,Boisson B,Pescatore A,Picard C,Hadj-Rabia S,Royer G,Steffann J,Bonnefont JP,Ursini VM,Vabres P,Munnich A,Casanova JL,Bodemer C,Weil R,Agou F,Smahi A
Fri Dec 01 00:00:00 EST 2017
Integrin beta 1 inhibition alleviates the chronic hyperproliferative dermatitis phenotype of SHARPIN-deficient mice.
PloS one
Peuhu E,Salomaa SI,De Franceschi N,Potter CS,Sundberg JP,Pouwels J
Mon Oct 30 00:00:00 EDT 2017
Integrin beta 1 inhibition alleviates the chronic hyperproliferative dermatitis phenotype of SHARPIN-deficient mice.
PloS one
Peuhu E,Salomaa SI,De Franceschi N,Potter CS,Sundberg JP,Pouwels J
Mon Oct 30 00:00:00 EDT 2017
A Linear Diubiquitin-Based Probe for Efficient and Selective Detection of the Deubiquitinating Enzyme OTULIN.
Cell chemical biology
Weber A,Elliott PR,Pinto-Fernandez A,Bonham S,Kessler BM,Komander D,El Oualid F,Krappmann D
Thu Oct 19 00:00:00 EDT 2017
A Linear Diubiquitin-Based Probe for Efficient and Selective Detection of the Deubiquitinating Enzyme OTULIN.
Cell chemical biology
Weber A,Elliott PR,Pinto-Fernandez A,Bonham S,Kessler BM,Komander D,El Oualid F,Krappmann D
Thu Oct 19 00:00:00 EDT 2017
The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity.
Cell
Damgaard RB,Walker JA,Marco-Casanova P,Morgan NV,Titheradge HL,Elliott PR,McHale D,Maher ER,McKenzie ANJ,Komander D
Thu Aug 25 00:00:00 EDT 2016
The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity.
Cell
Damgaard RB,Walker JA,Marco-Casanova P,Morgan NV,Titheradge HL,Elliott PR,McHale D,Maher ER,McKenzie ANJ,Komander D
Thu Aug 25 00:00:00 EDT 2016
SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling.
Molecular cell
Elliott PR,Leske D,Hrdinka M,Bagola K,Fiil BK,McLaughlin SH,Wagstaff J,Volkmar N,Christianson JC,Kessler BM,Freund SM,Komander D,Gyrd-Hansen M
Thu Sep 15 00:00:00 EDT 2016
SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling.
Molecular cell
Elliott PR,Leske D,Hrdinka M,Bagola K,Fiil BK,McLaughlin SH,Wagstaff J,Volkmar N,Christianson JC,Kessler BM,Freund SM,Komander D,Gyrd-Hansen M
Thu Sep 15 00:00:00 EDT 2016
--LUBAC deficiency perturbs TLR3 signaling to cause immunodeficiency and autoinflammation.
The Journal of experimental medicine
Zinngrebe J,Rieser E,Taraborrelli L,Peltzer N,Hartwig T,Ren H,Kovács I,Endres C,Draber P,Darding M,von Karstedt S,Lemke J,Dome B,Bergmann M,Ferguson BJ,Walczak H
Mon Nov 14 00:00:00 EST 2016
--LUBAC deficiency perturbs TLR3 signaling to cause immunodeficiency and autoinflammation.
The Journal of experimental medicine
Zinngrebe J,Rieser E,Taraborrelli L,Peltzer N,Hartwig T,Ren H,Kovács I,Endres C,Draber P,Darding M,von Karstedt S,Lemke J,Dome B,Bergmann M,Ferguson BJ,Walczak H
Mon Nov 14 00:00:00 EST 2016
SPATA2 promotes CYLD activity and regulates TNF-induced NF-κB signaling and cell death.
EMBO reports
Schlicher L,Wissler M,Preiss F,Brauns-Schubert P,Jakob C,Dumit V,Borner C,Dengjel J,Maurer U
Sat Oct 01 00:00:00 EDT 2016
SPATA2 promotes CYLD activity and regulates TNF-induced NF-κB signaling and cell death.
EMBO reports
Schlicher L,Wissler M,Preiss F,Brauns-Schubert P,Jakob C,Dumit V,Borner C,Dengjel J,Maurer U
Sat Oct 01 00:00:00 EDT 2016
An Essential Role for SHARPIN in the Regulation of Caspase 1 Activity in Sepsis.
The American journal of pathology
Nastase MV,Zeng-Brouwers J,Frey H,Hsieh LT,Poluzzi C,Beckmann J,Schroeder N,Pfeilschifter J,Lopez-Mosqueda J,Mersmann J,Ikeda F,Iozzo RV,Dikic I,Schaefer L
Sun May 01 00:00:00 EDT 2016
An Essential Role for SHARPIN in the Regulation of Caspase 1 Activity in Sepsis.
The American journal of pathology
Nastase MV,Zeng-Brouwers J,Frey H,Hsieh LT,Poluzzi C,Beckmann J,Schroeder N,Pfeilschifter J,Lopez-Mosqueda J,Mersmann J,Ikeda F,Iozzo RV,Dikic I,Schaefer L
Sun May 01 00:00:00 EDT 2016
An Essential Role for SHARPIN in the Regulation of Caspase 1 Activity in Sepsis.
The American journal of pathology
Nastase MV,Zeng-Brouwers J,Frey H,Hsieh LT,Poluzzi C,Beckmann J,Schroeder N,Pfeilschifter J,Lopez-Mosqueda J,Mersmann J,Ikeda F,Iozzo RV,Dikic I,Schaefer L
Sun May 01 00:00:00 EDT 2016
An Essential Role for SHARPIN in the Regulation of Caspase 1 Activity in Sepsis.
The American journal of pathology
Nastase MV,Zeng-Brouwers J,Frey H,Hsieh LT,Poluzzi C,Beckmann J,Schroeder N,Pfeilschifter J,Lopez-Mosqueda J,Mersmann J,Ikeda F,Iozzo RV,Dikic I,Schaefer L
Sun May 01 00:00:00 EDT 2016
Molecular Determinants of Scaffold-induced Linear Ubiquitinylation of B Cell Lymphoma/Leukemia 10 (Bcl10) during T Cell Receptor and Oncogenic Caspase Recruitment Domain-containing Protein 11 (CARD11) Signaling.
The Journal of biological chemistry
Yang YK,Yang C,Chan W,Wang Z,Deibel KE,Pomerantz JL
Fri Dec 09 00:00:00 EST 2016
Molecular Determinants of Scaffold-induced Linear Ubiquitinylation of B Cell Lymphoma/Leukemia 10 (Bcl10) during T Cell Receptor and Oncogenic Caspase Recruitment Domain-containing Protein 11 (CARD11) Signaling.
The Journal of biological chemistry
Yang YK,Yang C,Chan W,Wang Z,Deibel KE,Pomerantz JL
Fri Dec 09 00:00:00 EST 2016
CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling.
Cell reports
Hrdinka M,Fiil BK,Zucca M,Leske D,Bagola K,Yabal M,Elliott PR,Damgaard RB,Komander D,Jost PJ,Gyrd-Hansen M
Tue Mar 29 00:00:00 EDT 2016
CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling.
Cell reports
Hrdinka M,Fiil BK,Zucca M,Leske D,Bagola K,Yabal M,Elliott PR,Damgaard RB,Komander D,Jost PJ,Gyrd-Hansen M
Tue Mar 29 00:00:00 EDT 2016
SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes.
Cell reports
Kupka S,De Miguel D,Draber P,Martino L,Surinova S,Rittinger K,Walczak H
Tue Aug 30 00:00:00 EDT 2016
SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes.
Cell reports
Kupka S,De Miguel D,Draber P,Martino L,Surinova S,Rittinger K,Walczak H
Tue Aug 30 00:00:00 EDT 2016
Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis.
Nature communications
Nakazawa S,Oikawa D,Ishii R,Ayaki T,Takahashi H,Takeda H,Ishitani R,Kamei K,Takeyoshi I,Kawakami H,Iwai K,Hatada I,Sawasaki T,Ito H,Nureki O,Tokunaga F
Wed Aug 24 00:00:00 EDT 2016
Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis.
Nature communications
Nakazawa S,Oikawa D,Ishii R,Ayaki T,Takahashi H,Takeda H,Ishitani R,Kamei K,Takeyoshi I,Kawakami H,Iwai K,Hatada I,Sawasaki T,Ito H,Nureki O,Tokunaga F
Wed Aug 24 00:00:00 EDT 2016
Human HOIP and LUBAC deficiency underlies autoinflammation, immunodeficiency, amylopectinosis, and lymphangiectasia.
The Journal of experimental medicine
Boisson B,Laplantine E,Dobbs K,Cobat A,Tarantino N,Hazen M,Lidov HG,Hopkins G,Du L,Belkadi A,Chrabieh M,Itan Y,Picard C,Fournet JC,Eibel H,Tsitsikov E,Pai SY,Abel L,Al-Herz W,Casanova JL,Israel A,Notarangelo LD
Mon Jun 01 00:00:00 EDT 2015
Human HOIP and LUBAC deficiency underlies autoinflammation, immunodeficiency, amylopectinosis, and lymphangiectasia.
The Journal of experimental medicine
Boisson B,Laplantine E,Dobbs K,Cobat A,Tarantino N,Hazen M,Lidov HG,Hopkins G,Du L,Belkadi A,Chrabieh M,Itan Y,Picard C,Fournet JC,Eibel H,Tsitsikov E,Pai SY,Abel L,Al-Herz W,Casanova JL,Israel A,Notarangelo LD
Mon Jun 01 00:00:00 EDT 2015
The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice.
Journal of immunology (Baltimore, Md. : 1950)
Douglas T,Champagne C,Morizot A,Lapointe JM,Saleh M
Tue Sep 01 00:00:00 EDT 2015
The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice.
Journal of immunology (Baltimore, Md. : 1950)
Douglas T,Champagne C,Morizot A,Lapointe JM,Saleh M
Tue Sep 01 00:00:00 EDT 2015
LUBAC-Recruited CYLD and A20 Regulate Gene Activation and Cell Death by Exerting Opposing Effects on Linear Ubiquitin in Signaling Complexes.
Cell reports
Draber P,Kupka S,Reichert M,Draberova H,Lafont E,de Miguel D,Spilgies L,Surinova S,Taraborrelli L,Hartwig T,Rieser E,Martino L,Rittinger K,Walczak H
Tue Dec 15 00:00:00 EST 2015
LUBAC-Recruited CYLD and A20 Regulate Gene Activation and Cell Death by Exerting Opposing Effects on Linear Ubiquitin in Signaling Complexes.
Cell reports
Draber P,Kupka S,Reichert M,Draberova H,Lafont E,de Miguel D,Spilgies L,Surinova S,Taraborrelli L,Hartwig T,Rieser E,Martino L,Rittinger K,Walczak H
Tue Dec 15 00:00:00 EST 2015
Cellular IAP proteins and LUBAC differentially regulate necrosome-associated RIP1 ubiquitination.
Cell death & disease
de Almagro MC,Goncharov T,Newton K,Vucic D
Thu Jun 25 00:00:00 EDT 2015
Binding of OTULIN to the PUB domain of HOIP controls NF-κB signaling.
Molecular cell
Schaeffer V,Akutsu M,Olma MH,Gomes LC,Kawasaki M,Dikic I
Thu May 08 00:00:00 EDT 2014
Binding of OTULIN to the PUB domain of HOIP controls NF-κB signaling.
Molecular cell
Schaeffer V,Akutsu M,Olma MH,Gomes LC,Kawasaki M,Dikic I
Thu May 08 00:00:00 EDT 2014
Molecular basis and regulation of OTULIN-LUBAC interaction.
Molecular cell
Elliott PR,Nielsen SV,Marco-Casanova P,Fiil BK,Keusekotten K,Mailand N,Freund SM,Gyrd-Hansen M,Komander D
Thu May 08 00:00:00 EDT 2014
Molecular basis and regulation of OTULIN-LUBAC interaction.
Molecular cell
Elliott PR,Nielsen SV,Marco-Casanova P,Fiil BK,Keusekotten K,Mailand N,Freund SM,Gyrd-Hansen M,Komander D
Thu May 08 00:00:00 EDT 2014
TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice.
eLife
Rickard JA,Anderton H,Etemadi N,Nachbur U,Darding M,Peltzer N,Lalaoui N,Lawlor KE,Vanyai H,Hall C,Bankovacki A,Gangoda L,Wong WW,Corbin J,Huang C,Mocarski ES,Murphy JM,Alexander WS,Voss AK,Vaux DL,Kaiser WJ,Walczak H,Silke J
Tue Dec 02 00:00:00 EST 2014
TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice.
eLife
Rickard JA,Anderton H,Etemadi N,Nachbur U,Darding M,Peltzer N,Lalaoui N,Lawlor KE,Vanyai H,Hall C,Bankovacki A,Gangoda L,Wong WW,Corbin J,Huang C,Mocarski ES,Murphy JM,Alexander WS,Voss AK,Vaux DL,Kaiser WJ,Walczak H,Silke J
Tue Dec 02 00:00:00 EST 2014
HOIP deficiency causes embryonic lethality by aberrant TNFR1-mediated endothelial cell death.
Cell reports
Peltzer N,Rieser E,Taraborrelli L,Draber P,Darding M,Pernaute B,Shimizu Y,Sarr A,Draberova H,Montinaro A,Martinez-Barbera JP,Silke J,Rodriguez TA,Walczak H
Thu Oct 09 00:00:00 EDT 2014
HOIP deficiency causes embryonic lethality by aberrant TNFR1-mediated endothelial cell death.
Cell reports
Peltzer N,Rieser E,Taraborrelli L,Draber P,Darding M,Pernaute B,Shimizu Y,Sarr A,Draberova H,Montinaro A,Martinez-Barbera JP,Silke J,Rodriguez TA,Walczak H
Thu Oct 09 00:00:00 EDT 2014
OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin.
Cell
Keusekotten K,Elliott PR,Glockner L,Fiil BK,Damgaard RB,Kulathu Y,Wauer T,Hospenthal MK,Gyrd-Hansen M,Krappmann D,Hofmann K,Komander D
Thu Jun 06 00:00:00 EDT 2013
OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin.
Cell
Keusekotten K,Elliott PR,Glockner L,Fiil BK,Damgaard RB,Kulathu Y,Wauer T,Hospenthal MK,Gyrd-Hansen M,Krappmann D,Hofmann K,Komander D
Thu Jun 06 00:00:00 EDT 2013
OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin.
Cell
Keusekotten K,Elliott PR,Glockner L,Fiil BK,Damgaard RB,Kulathu Y,Wauer T,Hospenthal MK,Gyrd-Hansen M,Krappmann D,Hofmann K,Komander D
Thu Jun 06 00:00:00 EDT 2013
OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin.
Cell
Keusekotten K,Elliott PR,Glockner L,Fiil BK,Damgaard RB,Kulathu Y,Wauer T,Hospenthal MK,Gyrd-Hansen M,Krappmann D,Hofmann K,Komander D
Thu Jun 06 00:00:00 EDT 2013
Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis.
Nature immunology
Yang S,Wang B,Humphries F,Jackson R,Healy ME,Bergin R,Aviello G,Hall B,McNamara D,Darby T,Quinlan A,Shanahan F,Melgar S,Fallon PG,Moynagh PN
Sun Sep 01 00:00:00 EDT 2013
Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis.
Nature immunology
Yang S,Wang B,Humphries F,Jackson R,Healy ME,Bergin R,Aviello G,Hall B,McNamara D,Darby T,Quinlan A,Shanahan F,Melgar S,Fallon PG,Moynagh PN
Sun Sep 01 00:00:00 EDT 2013
OTULIN restricts Met1-linked ubiquitination to control innate immune signaling.
Molecular cell
Fiil BK,Damgaard RB,Wagner SA,Keusekotten K,Fritsch M,Bekker-Jensen S,Mailand N,Choudhary C,Komander D,Gyrd-Hansen M
Thu Jun 27 00:00:00 EDT 2013
OTULIN restricts Met1-linked ubiquitination to control innate immune signaling.
Molecular cell
Fiil BK,Damgaard RB,Wagner SA,Keusekotten K,Fritsch M,Bekker-Jensen S,Mailand N,Choudhary C,Komander D,Gyrd-Hansen M
Thu Jun 27 00:00:00 EDT 2013
Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling.
EMBO molecular medicine
Damgaard RB,Fiil BK,Speckmann C,Yabal M,zur Stadt U,Bekker-Jensen S,Jost PJ,Ehl S,Mailand N,Gyrd-Hansen M
Thu Aug 01 00:00:00 EDT 2013
Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling.
EMBO molecular medicine
Damgaard RB,Fiil BK,Speckmann C,Yabal M,zur Stadt U,Bekker-Jensen S,Jost PJ,Ehl S,Mailand N,Gyrd-Hansen M
Thu Aug 01 00:00:00 EDT 2013
Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency.
Nature immunology
Boisson B,Laplantine E,Prando C,Giliani S,Israelsson E,Xu Z,Abhyankar A,Israël L,Trevejo-Nunez G,Bogunovic D,Cepika AM,MacDuff D,Chrabieh M,Hubeau M,Bajolle F,Debré M,Mazzolari E,Vairo D,Agou F,Virgin HW,Bossuyt X,Rambaud C,Facchetti F,Bonnet D,Quartier P,Fournet JC,Pascual V,Chaussabel D,Notarangelo LD,Puel A,Israël A,Casanova JL,Picard C
Sat Dec 01 00:00:00 EST 2012
Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency.
Nature immunology
Boisson B,Laplantine E,Prando C,Giliani S,Israelsson E,Xu Z,Abhyankar A,Israël L,Trevejo-Nunez G,Bogunovic D,Cepika AM,MacDuff D,Chrabieh M,Hubeau M,Bajolle F,Debré M,Mazzolari E,Vairo D,Agou F,Virgin HW,Bossuyt X,Rambaud C,Facchetti F,Bonnet D,Quartier P,Fournet JC,Pascual V,Chaussabel D,Notarangelo LD,Puel A,Israël A,Casanova JL,Picard C
Sat Dec 01 00:00:00 EST 2012
The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity.
Molecular cell
Damgaard RB,Nachbur U,Yabal M,Wong WW,Fiil BK,Kastirr M,Rieser E,Rickard JA,Bankovacki A,Peschel C,Ruland J,Bekker-Jensen S,Mailand N,Kaufmann T,Strasser A,Walczak H,Silke J,Jost PJ,Gyrd-Hansen M
Fri Jun 29 00:00:00 EDT 2012
The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity.
Molecular cell
Damgaard RB,Nachbur U,Yabal M,Wong WW,Fiil BK,Kastirr M,Rieser E,Rickard JA,Bankovacki A,Peschel C,Ruland J,Bekker-Jensen S,Mailand N,Kaufmann T,Strasser A,Walczak H,Silke J,Jost PJ,Gyrd-Hansen M
Fri Jun 29 00:00:00 EDT 2012
