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Product Details
12436-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SHC3 Fusion Protein Ag3115 (244-594 aa encoded by BC026314)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: IIANHHMRS ISFASGGDPD TTDYVAYVTK DPVNRRACHI LECCDGLAQD VIGSIGQAFE LRFKQYLQCP TKIPALHDRM QSLDEPWTEE EGDGSDHPYY NSIPSKMPPP GGFLDTRLKP RPHAPDTAQF AGKEQTYYQG RHLGDTFGED WQQTPLRQGS SDIYSTPEGK LHVAPTGEAP TYVNTQQIPP QAWPAAVSSA ESSPRKDLFD MKPFEDALKN QPLGPVLSKA ASVECISPVS PRAPDAKMLE ELQAETWYQG EMSRKEAEGL LEKDGDFLVR KSTTNPGSFV LTGMHNGQAK HLLLVDPEGT IQTKDRVFDS ISHLINHHLE SSLPIVSAGS ELCLQQPVER KQ (244-594 aa encoded by BC026314)
Target Information
Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: N-Shc; Neuronal Shc; Protein Rai; SH2 domain protein C3; SHC (Src homology 2 domain containing) transforming protein 3; SHC-transforming protein 3; SHC-transforming protein C; Shc3 p51; src homology 2 domain-containing transforming protein C3; Src homology 2 domain-containing-transforming protein C3
Gene Aliases: N-Shc; NSHC; RAI; SHC3; SHCC
UniProt ID: (Human) Q92529, (Mouse) Q3ZAX2
Entrez Gene ID: (Human) 53358, (Rat) 114858, (Mouse) 20418
MAPK cascade
transmembrane receptor protein tyrosine kinase signaling pathway
epidermal growth factor receptor signaling pathway
Ras protein signal transduction
central nervous system development
learning or memory
synaptic transmission, glutamatergic
positive regulation of GTPase activity
intracellular signal transduction
signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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