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Product Details
PA5-17392
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues surrounding Asp1163 of human SHIP1
Conjugate
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_10976931
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hp51CN; Inositol polyphosphate-5-phosphatase 145 kDa; Inositol polyphosphate-5-phosphatase D; Inositol polyphosphate-5-phosphatase of 145 kDa; Inositol polyphosphate-5-phosphatase, 145 kDa; inositol polyphosphate-5-phosphatase, 145kD; inositol polyphosphate-5-phosphatase, 145kDa; MGC104855; MGC142140; MGC142142; OTTHUMP00000165069; OTTHUMP00000165070; OTTHUMP00000165071; OTTHUMP00000165072; OTTHUMP00000203442; p150Ship; phosphatidylin; Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1; Phosphatidylinositol 4,5-bisphosphate 5-phosphatase; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1; Phosphatidylinositol-4,5-bisphosphate 5-phosphatase; SH2 domain-containing inositol 5'-phosphatase 1; SH2 domain-containing inositol phosphatase 1; SH2 domain-containing inositol-5'-phosphatase 1; SH2-containing inositol phosphatase SHIP; SHIP-1; signaling inositol polyphosphate 5 phosphatase SIP-145; signaling inositol polyphosphate phosphatase SHIP II; SIP-145; Src homology 2 domain-containing inositol-5-phosphatase
Gene Aliases: 7a33; hp51CN; INPP5D; p150Ship; s-SHIP; SHIP; SHIP-1; SHIP1; SIP-145
UniProt ID: (Human) Q92835, (Mouse) Q9ES52, (Rat) P97573
Entrez Gene ID: (Human) 3635, (Mouse) 16331, (Rat) 54259
inositol-polyphosphate 5-phosphatase activity
protein binding
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
SH3 domain binding
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
PTB domain binding
inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
hydrolase activity
inositol-4,5-bisphosphate 5-phosphatase activity
phosphatidylinositol trisphosphate phosphatase activity
immune system process
apoptotic process
negative regulation of cell proliferation
determination of adult lifespan
negative regulation of signal transduction
immunoglobulin mediated immune response
dephosphorylation
negative regulation of granulocyte differentiation
negative regulation of B cell proliferation
intracellular signal transduction
positive regulation of apoptotic process
negative regulation of interleukin-6 biosynthetic process
positive regulation of B cell differentiation
positive regulation of lymphocyte differentiation
positive regulation of erythrocyte differentiation
negative regulation of monocyte differentiation
negative regulation of neutrophil differentiation
negative regulation of osteoclast differentiation
negative regulation of bone resorption
phosphatidylinositol dephosphorylation
negative regulation of immune response
negative regulation of B cell activation
phosphatidylinositol biosynthetic process
phosphate-containing compound metabolic process
signal transduction
inositol phosphate metabolic process
T cell receptor signaling pathway
leukocyte migration
biological_process
Performance Guarantee
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