Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
18218-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SHROOM1 Fusion Protein Ag12977 (503-852 aa encoded by BC104914)
Conjugate
Form
Liquid
Concentration
0.26 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: VPADALGLS GNDTPGPSHN TALARGTGQP GSRPTWPSQC LEELVQELAR LDPSLCDPLA SQPSPEPPLG LLDGLIPLAE VRAAMRPACG EAGEEAASTF EPGSYQFSFT QLLPAPREET RLENPATHPV LDQPCGQGLP APNNSIQGKK VELAARLQKM LQDLHTEQER LQGEAQAWAR RQAALEAAVR QACAPQELER FSRFMADLER VLGLLLLLGS RLARVRRALA RAASDSDPDE QASLLQRLRL LQRQEEDAKE LKEHVARRER AVREVLVRAL PVEELRVYCA LLAGKAAVLA QQRNLDERIR LLQDQLDAIR DDLGHHAPSP SPARPPGTCP PVQPPFPLLL T (503-852 aa encoded by BC104914)
Target Information
SHROOM family members play diverse roles in the development of the nervous system and other tissues. SHROOM1 is a PDZ domain-containing actin-binding protein that is required for neural tube morphogenesis. It facilitates neurulation by regulating the morphology of neurepithelial cells via the apical positioning of an actomyosin network in the neurepithelium. SHROOM1 is also expressed in pulmonary arterial smooth muscle cells and its expression is significantly decreased in mouse and human models of pulmonary arterial hypertension, suggesting that there may be a link between SHROOM1 expression and pulmonary arterial hypertension.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Apical protein 2; Protein Shroom1; Shroom
Gene Aliases: APXL2; KIAA1960; SHROOM1
UniProt ID: (Human) Q2M3G4
Entrez Gene ID: (Human) 134549
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support