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Product Details
PA5-29682
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fragment corresponding to a region within amino acids 33 and 282 of Human SIAH1
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2547157
Product Specific Information
Recommended positive controls: U87-MG.
Predicted reactivity: Rat (99%), Zebrafish (97%), Xenopus laevis (99%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes a protein that is a member of the seven in absentia homolog family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E3 ubiquitin-protein ligase SIAH1; FLJ08065; h HUMSIAH; hSIAH1; RING-type E3 ubiquitin transferase SIAH1; Seven in absentia homolog 1; Siah-1; Siah-1a
Gene Aliases: HUMSIAH; SIAH1; SIAH1A
UniProt ID: (Human) Q8IUQ4
Entrez Gene ID: (Human) 6477
protein polyubiquitination
ubiquitin-dependent protein catabolic process
apoptotic process
cell cycle
spermatogenesis
nervous system development
axon guidance
anatomical structure morphogenesis
protein catabolic process
protein destabilization
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
positive regulation of apoptotic process
proteasome-mediated ubiquitin-dependent protein catabolic process
cellular protein metabolic process
neuron apoptotic process
positive regulation of intrinsic apoptotic signaling pathway
Performance Guarantee
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