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Product Details
H00089858-M01
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
1D1
Immunogen
SIGLEC12 (NP_443729.1, 503 a.a. approximately 595 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
2 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
Immunogen sequence: RSCRKKSARP AVGVGDTGME DANAVRGSAS QGPLIESPAD DSPPHHAPPA LATPSPEEGE IQYASLSFHK ARPQYPQEQE AIGYEYSEIN IPK
Target Information
Sialic acid-binding immunoglobulin-like lectins are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: sialic acid binding Ig-like lectin 12; Sialic acid-binding Ig-like lectin 12; Sialic acid-binding Ig-like lectin-like 1; Siglec; Siglec-12; Siglec-L1; SIGLEC-like 1
Gene Aliases: S2V; Siglec-XII; SIGLEC12; SIGLECL1; SLG; UNQ9215/PRO34042
UniProt ID: (Human) Q96PQ1
Entrez Gene ID: (Human) 89858
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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