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Product Details
22432-1-AP
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SIKE1 Fusion Protein Ag18196 (108-207 aa encoded by BC005934)
Conjugate
Form
Liquid
Concentration
0.39 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: YRKQMLQLM VAKKAVDAEP VLKAHQSHSA EIESQIDRIC EMGEVMRKAV QVDDDQFCKI QEKLAQLELE NKELRELLSI SSESLQARKE NSMDTASQAI K (108-207 aa encoded by BC005934)
Target Information
Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Suppressor of IKBKE 1; suppressor of IKK epsilon; Suppressor of IKK-epsilon
Gene Aliases: SIKE; SIKE1
UniProt ID: (Human) Q9BRV8
Entrez Gene ID: (Human) 80143
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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