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Product Details
PA5-68785
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
synthetic peptide directed towards the N terminal region of mouse SIN3B
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2691102
Product Specific Information
This target displays homology in the following species: Mouse: 100%; Rat: 92%
Target Information
Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Histone deacetylase complex subunit Sin3b; Paired amphipathic helix protein Sin3b; SIN3 homolog B, transcription regulator; SIN3 homolog B, transcriptional regulator; SIN3 transcription regulator homolog B; SIN3B; Transcriptional corepressor Sin3b; transcriptional regulator, SIN3 yeast homolog B
Gene Aliases: 2810430C10Rik; KIAA0700; SIN3B
UniProt ID: (Human) O75182, (Mouse) Q62141
Entrez Gene ID: (Human) 23309, (Mouse) 20467
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
skeletal muscle tissue development
histone deacetylation
cellular lipid metabolic process
cardiac muscle tissue development
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
negative regulation of cell cycle
negative regulation of transcription, DNA-templated
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