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The product of this gene is a mitogen induced GTPase activating protein. It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date.
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Protein Aliases: GTPase-activating protein Spa-1; MGC102688; MGC17037; p130 SPA-1; signal-induced proliferation-associated gene 1; Signal-induced proliferation-associated protein 1; Sipa-1
Gene Aliases: SIPA1; SPA1
UniProt ID: (Human) Q96FS4
Entrez Gene ID: (Human) 6494
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