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SIPA1L2 Antibody (BS-7927R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded human cervical cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (normal goat serum) at 37°C for 20min; Antibody incubation with Rabbit Anti-SIPA1L2 Polyclonal Antibody, Unconjugated (bs-7927R) at 1:500 overnight at 4°C, followed by a conjugated secondary... View More
Product Details
BS-7927R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human SIPA1L2, amino acids 251-350.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Signal-induced proliferation associated-like protein 2 (SIPA1L2) is a member of the SIPA1 family of RapGAPs. Little is known of the role of the SIPA1L2 protein, but recent studies of SIPA indicate that its deregulation can cause myeloproliferative stem cell disorders in mice and increased metastases in human cancers. Other studies suggest SIPA1L1 may play important roles in embryo development and control of cell proliferation. Based on the amount of homology between SIPA family members, it is likely that SIPA1L2 plays a role in embryo development and cell proliferation, possibly including oncogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: serine-rich synapse associated protein 2; Serine-rich synapse-associated protein; signal-induced proliferation-associated 1 like 2; Signal-induced proliferation-associated 1-like protein 2; SIPA1-like protein 2; SPA-1-like 2
Gene Aliases: BC058408; Kiaa0545; KIAA1389; mKIAA1389; Sersap2; SIPA1L2; SPAL2; Spar2
UniProt ID: (Human) Q9P2F8, (Mouse) Q80TE4, (Rat) Q5JCS6
Entrez Gene ID: (Human) 57568, (Mouse) 244668, (Rat) 361442
Performance Guarantee
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