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Product Details
PA5-59853
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SIPA1L3. Recombinant protein control fragment (Product #RP-98995).
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2647313
Product Specific Information
Immunogen sequence: KGGSSDSGID TTLYTSSPSC MSLAKAPRPA KPHKPPGSMG LCGGGREAAG RSHHADRRRE VSPAPAVAGQ SKGYRPKLYS SG
Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 89%.
Target Information
Signal-induced proliferation associated-like protein 2 (SIPA1L3) is a member of the SIPA1 family of RapGAPs. SIPA1L3 was cloned as a novel molecular component of tight junctions and adherens junctions, suggesting that may function to balance Rap1 by counteracting RapGEFs. Recent studies of SIPA indicate that its deregulation can cause myeloproliferative stem cell disorders in mice and increased metastases in human cancers. Other studies suggest SIPA1L1 may play important roles in embryo development and control of cell proliferation. Based on the amount of homology between SIPA family members, it is possible that SIPA1L3 plays other roles development and cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: signal-induced proliferation-associated 1 like 3; Signal-induced proliferation-associated 1-like protein 3; SIPA1-like protein 3; SPA-1-like 3; SPA-1-like protein 3
Gene Aliases: CTRCT45; KIAA0545; SIPA1L3; SPAL3; SPAR3
UniProt ID: (Human) O60292
Entrez Gene ID: (Human) 23094
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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