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Invitrogen
SIRP beta/gamma Chimeric Recombinant Rabbit Monoclonal Antibody (OX117)
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SIRP beta/gamma Chimeric Antibody (MA5-47960) in Flow
Flow Cytometry analysis of SIRP beta/gamma in Human lymphocytes using SIRP beta/gamma Chimeric Monoclonal Antibody (Product # MA5-47960). Cells were stained with an isotype control, FITC Chimeric monoclonal antibody (Product # MA5-47752) (panel A), or SIRP beta/gamma Chimeric Monoclonal Antibody (panel B) at a concentration of 1 µg/mL for 30 mins at RT. After washing, bound antibody was detected using a AF4... View More
Product Details
MA5-47960
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
OX117
Immunogen
Recombinant human SIRPgamma:CD4 fusion protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.02% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_3074404
Product Specific Information
Specificity: This antibody binds to human SIRP-beta and gamma.
Target Information
SIRP beta and SIRP gamma are two members of the signal regulatory protein (SIRP) family. These proteins are transmembrane receptors that are expressed on the surface of various cells, including immune cells and neurons. The function of SIRP beta and SIRP gamma is to regulate cellular signaling pathways that are involved in immune responses, cell adhesion, and phagocytosis. Specifically, these proteins interact with the protein tyrosine phosphatase SHP-1, which is a negative regulator of immune cell activation. By binding to SHP-1, SIRP beta and SIRP gamma can inhibit immune cell activation and promote immune tolerance. In addition to their role in immune regulation, SIRP beta and SIRP gamma have also been implicated in neuronal signaling and synaptic plasticity. These proteins are thought to play a role in the formation and maintenance of synapses, as well as in the regulation of neuronal activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD172 antigen-like family member B; CD172b; CD172g; CD172g antigen; signal-regulatory protein beta 1; signal-regulatory protein beta 2; Signal-regulatory protein beta-1; Signal-regulatory protein beta-1 isoform 3; Signal-regulatory protein beta-2; Signal-regulatory protein gamma; SIRP beta 2; SIRP-b2; SIRP-beta-1; SIRP-beta-1 isoform 3; SIRP-beta-2; SIRP-gamma
Gene Aliases: bA77C3.1; CD172b; CD172g; SIRP-B2; SIRP-BETA-1; SIRPB1; SIRPB2; SIRPG; SIRPgamma
UniProt ID: (Human) O00241, (Human) Q9P1W8
Entrez Gene ID: (Human) 10326, (Human) 55423
signal transduction
cell surface receptor signaling pathway
innate immune response
cell adhesion
cell-cell signaling
positive regulation of cell proliferation
negative regulation of cell proliferation
positive regulation of cell-cell adhesion
intracellular signal transduction
positive regulation of T cell activation
leukocyte migration
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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