Invitrogen

SIRT2 Polyclonal Antibody

View all (29) SIRT2 antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-20490

Applications
Tested Dilution
Publications

Western Blot (WB)

2.5-5 µg/mL
-

Immunohistochemistry (IHC)

2.5 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A 17 amino acid peptide near the amino terminus of the human SIRT2.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_11152520

Product Specific Information

A suggested positive control is human brain tissue lysate.

PA5-20490 can be used with blocking peptide PEP-0610.

Target Information

The SIRT2 protein (also known as Sirtuin for Silent Mating Type Information 2-Homolog) is a NAD-dependent deacytylase (NDAC) that has been shown to control gene silencing, cell cycle, and DNA damage repair. It is believed that SIRT2 may act as a tumor suppressor in human gliomas and may also serve as a novel molecular marker for these cells. SIRT2 has also been shown to act as a redox sensor to help regulate muscle gene expression in response to food intake and exercise. SIRT2 acts in the phosphorylation cascade involving mitosis where SIRT2 is phosphorylated in late G2 phase, during M phase, and into cytokinesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 5E5 antigen; mSIR2L2; NAD-dependent deacetylase sirtuin-2; NAD-dependent protein deacetylase sirtuin-2; NAD-dependent protein defatty-acylase sirtuin-2; Regulatory protein SIR2 homolog 2; silent information regulator 2; silent mating type information regulation 2, (S.cerevisiae, homolog)-like; sirtuin 2; SIR2-like protein 2; sir2-related protein type 2; sirtuin type 2; sirtuin-2

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Gene Aliases: 5730427M03Rik; SIR2; SIR2L; SIR2L2; SIRT2

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UniProt ID: (Human) Q8IXJ6, (Mouse) Q8VDQ8

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Entrez Gene ID: (Human) 22933, (Mouse) 64383, (Rat) 361532

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Function(s)
chromatin binding NAD+ ADP-ribosyltransferase activity histone deacetylase activity protein binding transcription factor binding zinc ion binding NAD-dependent histone deacetylase activity protein deacetylase activity NAD-dependent protein deacetylase activity histone acetyltransferase binding histone deacetylase binding tubulin deacetylase activity ubiquitin binding NAD-dependent histone deacetylase activity (H4-K16 specific) beta-tubulin binding NAD+ binding protein-N-terminal asparagine amidohydrolase activity UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides iprodione amidohydrolase activity (3,5-dichlorophenylurea)acetate amidohydrolase activity 4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity didemethylisoproturon amidohydrolase activity N-isopropylacetanilide amidohydrolase activity N-cyclohexylformamide amidohydrolase activity isonicotinic acid hydrazide hydrolase activity cis-aconitamide amidase activity gamma-N-formylaminovinylacetate hydrolase activity N2-acetyl-L-lysine deacetylase activity O-succinylbenzoate synthase activity indoleacetamide hydrolase activity N-acetylcitrulline deacetylase activity metal ion binding N-acetylgalactosamine-6-phosphate deacetylase activity NAD binding diacetylchitobiose deacetylase activity chitooligosaccharide deacetylase activity molecular_function
Process(es)
negative regulation of transcription from RNA polymerase II promoter transcription, DNA-templated regulation of transcription, DNA-templated protein deacetylation autophagy cell cycle mitotic nuclear division nervous system development negative regulation of cell proliferation negative regulation of autophagy negative regulation of peptidyl-threonine phosphorylation phosphatidylinositol 3-kinase signaling histone deacetylation myelination in peripheral nervous system cell differentiation regulation of myelination positive regulation of proteasomal ubiquitin-dependent protein catabolic process cellular response to oxidative stress peptidyl-lysine deacetylation cellular response to hepatocyte growth factor stimulus negative regulation of protein catabolic process negative regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of DNA binding protein kinase B signaling cellular lipid catabolic process regulation of fat cell differentiation negative regulation of fat cell differentiation positive regulation of meiotic nuclear division negative regulation of striated muscle tissue development negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter hepatocyte growth factor receptor signaling pathway negative regulation of oligodendrocyte differentiation cell division meiotic cell cycle regulation of cell cycle positive regulation of cell division positive regulation of attachment of spindle microtubules to kinetochore negative regulation of transcription from RNA polymerase II promoter in response to hypoxia cellular response to caloric restriction negative regulation of oligodendrocyte progenitor proliferation histone H3 deacetylation histone H4 deacetylation cellular response to molecule of bacterial origin cellular response to hypoxia cellular response to epinephrine stimulus tubulin deacetylation positive regulation of execution phase of apoptosis positive regulation of oocyte maturation negative regulation of NLRP3 inflammasome complex assembly negative regulation of defense response to bacterium ripoptosome assembly involved in necroptotic process negative regulation of reactive oxygen species metabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia central nervous system development substantia nigra development chromatin silencing at rDNA chromatin silencing chromatin silencing at telomere protein ADP-ribosylation regulation of exit from mitosis gene silencing regulation of phosphorylation innate immune response response to redox state
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