Invitrogen

SIRT5 Recombinant Rabbit Monoclonal Antibody (2U8A2)

View all (36) SIRT5 antibodies
Datasheet
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Datasheet
Protocols
Questions & Answers

Product Details

MA5-55336

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:5,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

2U8A2

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 37-310 of human SIRT5.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.89 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.05% ProClin 300

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Dry ice (international)

Product Specific Information

Immunogen Sequence: SSSMADFRKF FAKAKHIVII SGAGVSAESG VPTFRGAGGY WRKWQAQDLA TPLAFAHNPS RVWEFYHYRR EVMGSKEPNA GHRAIAECET RLGKQGRRVV VITQNIDELH RKAGTKNLLE IHGSLFKTRC TSCGVVAENY KSPICPALSG KGAPEPGTQD ASIPVEKLPR CEEAGCGGLL RPHVVWFGEN LDPAILEEVD RELAHCDLCL VVGTSSVVYP AAMFAPQVAA RGVPVAEFNT ETTPATNRFR FHFQGPCGTT LPEALACHEN ETVS

Target Information

SIRT5 is a human member of a family of proteins called Sirtuins (Sir2-like proteins) and are present in prokaryotes and eukaryotes. All Sir2-like proteins have a sirtuin core domain, which contains a series of sequence motifs conserved in organisms ranging from bacteria to humans. Bacterial, yeast and mammalian sirtuins are able to metabolize NAD and possibly at as mono-ADP-ribosyltransferases. The enzymatic function of sirtuins is not yet completely understood but recent reports of histone-activated Sir2-mediated NAD metabolism and NAD-activated Sir2-mediated histone deacetylation suggest a possible coupled reciprocal activation mechanism involving interactions of Sir2 with NAD and the N epsilon-acetyl-lysine groups of acetylated histones.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: FLJ36950; NAD-dependent deacetylase sirtuin-5; NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial; NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent protein deacylase sirtuin-5, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03160}; Regulatory protein SIR2 homolog 5; regulatory protein SIR2 homolog 5 {ECO:0000255|HAMAP-Rule:MF_03160}; silent mating type information regulation 2, S.cerevisiae, homolog 5; sir2-like 5; SIR2-like protein 5; SIR2-like protein 5 {ECO:0000255|HAMAP-Rule:MF_03160}; SIRT5; sirtuin type 5

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Gene Aliases: 0610012J09Rik; 1500032M05Rik; AV001953; SIR2L5; SIRT5

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UniProt ID: (Human) F5H5Z9, (Mouse) Q8K2C6, (Rat) Q68FX9

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Entrez Gene ID: (Human) 23408, (Mouse) 68346, (Rat) 306840

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Function(s)
NAD+ ADP-ribosyltransferase activity zinc ion binding protein-malonyllysine demalonylase activity protein-succinyllysine desuccinylase activity protein-glutaryllysine deglutarylase activity NAD+ binding histone deacetylase activity protein binding protein-N-terminal asparagine amidohydrolase activity UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity hydrolase activity iprodione amidohydrolase activity (3,5-dichlorophenylurea)acetate amidohydrolase activity 4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity didemethylisoproturon amidohydrolase activity N-isopropylacetanilide amidohydrolase activity N-cyclohexylformamide amidohydrolase activity isonicotinic acid hydrazide hydrolase activity cis-aconitamide amidase activity gamma-N-formylaminovinylacetate hydrolase activity N2-acetyl-L-lysine deacetylase activity O-succinylbenzoate synthase activity indoleacetamide hydrolase activity N-acetylcitrulline deacetylase activity metal ion binding N-acetylgalactosamine-6-phosphate deacetylase activity diacetylchitobiose deacetylase activity chitooligosaccharide deacetylase activity molecular_function
Process(es)
chromatin silencing protein ADP-ribosylation protein deacetylation regulation of ketone biosynthetic process negative regulation of cardiac muscle cell apoptotic process response to nutrient levels protein demalonylation peptidyl-lysine demalonylation protein desuccinylation peptidyl-lysine desuccinylation protein deglutarylation peptidyl-lysine deglutarylation negative regulation of reactive oxygen species metabolic process
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