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Product Details
67741-1-IG
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rabbit,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2D7D1
Immunogen
SIX1 Fusion Protein Ag28570
Conjugate
Form
Liquid
Concentration
1000 µg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Homeobox protein SIX1; Sine oculis homeobox homolog 1; sine oculis-related homeobox 1 homolog
Gene Aliases: BB138287; BOS3; DFNA23; SIX1; TIP39
UniProt ID: (Human) Q15475, (Mouse) Q62231
Entrez Gene ID: (Human) 6495, (Rabbit) 100349440, (Pig) 100156847, (Mouse) 20471, (Rat) 114634
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
transcription regulatory region DNA binding
homeodomain transcription factor
negative regulation of transcription from RNA polymerase II promoter
ureteric bud development
branching involved in ureteric bud morphogenesis
organ induction
kidney development
outflow tract morphogenesis
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
apoptotic process
pattern specification process
skeletal muscle tissue development
sensory perception of sound
cell proliferation
regulation of synaptic growth at neuromuscular junction
regulation of skeletal muscle satellite cell proliferation
facial nerve morphogenesis
epithelial cell differentiation
thyroid gland development
olfactory placode formation
regulation of protein localization
protein localization to nucleus
aorta morphogenesis
inner ear morphogenesis
middle ear morphogenesis
negative regulation of neuron apoptotic process
regulation of neuron differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
thymus development
neuron fate specification
generation of neurons
embryonic cranial skeleton morphogenesis
embryonic skeletal system morphogenesis
inner ear development
regulation of epithelial cell proliferation
myoblast migration
pharyngeal system development
myotome development
fungiform papilla morphogenesis
trigeminal ganglion development
otic vesicle development
metanephric mesenchyme development
regulation of branch elongation involved in ureteric bud branching
positive regulation of ureteric bud formation
mesonephric tubule formation
ureter smooth muscle cell differentiation
positive regulation of secondary heart field cardioblast proliferation
cochlea morphogenesis
positive regulation of branching involved in ureteric bud morphogenesis
negative regulation of branching involved in ureteric bud morphogenesis
positive regulation of mesenchymal cell proliferation involved in ureter development
regulation of skeletal muscle cell differentiation
transcription, DNA-templated
multicellular organism development
regulation of gene expression
neurogenesis
negative regulation of apoptotic process
tongue development
skeletal system morphogenesis
anatomical structure development
renal system development
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