Alomone Labs, LTD

SLC11A1/NRAMP1 (extracellular) Polyclonal Antibody, FITC

View all (10) SLC11A1 antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

ANT-201-F-50UL

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

5 µg
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide CANSSLHDYAKIFP(R), corresponding to amino acid residues 322-335 of human SLC11A1, Extracellular, 4th loop
View immunogen

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra spectra

Form

Lyophilized

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 15 µL or 50 µL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Information

NRAMP1, also known as SLC11A1, is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as leprosy and tuberculosis, and inflammatory diseases such as Crohn disease and rheumatoid arthritis. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

How to use the Panel Builder

Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: host resistance locus Bcg/Ity/Lsh; natural resistance associated macrophage protein 1; Natural resistance-associated macrophage protein 1; NRAMP 1; solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1; solute carrier family 11 (sodium/phosphate symporters), member 1; Solute carrier family 11 member 1

View more View less

Gene Aliases: Bcg; Itg; Ity; LSH; NRAMP; NRAMP1; SLC11A1

View more View less

UniProt ID: (Human) P49279, (Mouse) P41251, (Rat) P70553

View more View less

Entrez Gene ID: (Human) 6556, (Mouse) 18173, (Rat) 316519

View more View less

Function(s)
manganese ion transmembrane transporter activity protein homodimerization activity transition metal ion transmembrane transporter activity metal ion:proton antiporter activity transporter activity molecular_function secondary carrier transporter
Process(es)
protein import into nucleus, translocation negative regulation of cytokine production positive regulation of cytokine production T cell proliferation involved in immune response T cell cytokine production positive regulation of dendritic cell antigen processing and presentation positive regulation of T-helper 1 type immune response iron ion transport manganese ion transport cellular cadmium ion homeostasis cellular iron ion homeostasis phagocytosis inflammatory response vacuolar acidification response to bacterium positive regulation of gene expression nitrite transport activation of protein kinase activity response to lipopolysaccharide interleukin-2 production interleukin-3 production positive regulation of interferon-gamma production response to interferon-gamma wound healing macrophage activation defense response to bacterium defense response to protozoan L-arginine import MHC class II biosynthetic process cell redox homeostasis respiratory burst positive regulation of transcription from RNA polymerase II promoter antigen processing and presentation of peptide antigen mRNA stabilization positive regulation of phagocytosis defense response to Gram-negative bacterium iron ion homeostasis multicellular organismal iron ion homeostasis cadmium ion transmembrane transport divalent metal ion export manganese ion transmembrane transport MAPK cascade transport ion transport hydrogen ion transmembrane transport biological_process
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support