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Product Details
H00004891-M01J
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
4C6
Immunogen
SLC11A2 (NP_000608, 1 a.a. approximately 65 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MVLGPEQKMS DDSVSGDHGE SASLGNINPA YSNPSLSQSP GDSEEYFATY FNEKISIPEE EYSCF
Target Information
This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dct-1; Divalent cation transporter 1; Divalent metal transporter 1; DMT-1; Natural resistance-associated macrophage protein 2; NRAMP 2; solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2; Solute carrier family 11 member 2
Gene Aliases: AHMIO1; DCT1; DMT1; NRAMP2; OK/SW-cl.20; SLC11A2
UniProt ID: (Human) P49281
Entrez Gene ID: (Human) 4891
copper ion transmembrane transporter activity
iron ion transmembrane transporter activity
manganese ion transmembrane transporter activity
protein binding
hydrogen ion transmembrane transporter activity
cadmium ion transmembrane transporter activity
cobalt ion transmembrane transporter activity
ferrous iron transmembrane transporter activity
lead ion transmembrane transporter activity
solute:proton symporter activity
ferrous iron uptake transmembrane transporter activity
transferrin transmembrane transporter activity
cadmium ion binding
transition metal ion transmembrane transporter activity
secondary carrier transporter
heme biosynthetic process
cobalt ion transport
copper ion transport
manganese ion transport
cellular iron ion homeostasis
learning or memory
response to iron ion
ferrous iron transport
lead ion transport
transferrin transport
copper ion transmembrane transport
dendrite morphogenesis
erythrocyte development
multicellular organismal iron ion homeostasis
cadmium ion transmembrane transport
ferrous iron import
manganese ion transmembrane transport
hydrogen ion transmembrane transport
ferrous iron transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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