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Transport of folate compounds into mammalian cells can occur via receptor-mediated or carrier-mediated mechanisms. A functional coordination between these 2 mechanisms has been proposed to be the method of folate uptake in certain cell types. Methotrexate (MTX) is an antifolate chemotherapeutic agent that is actively transported by the carrier-mediated uptake system. RFC1 plays a role in maintaining intracellular concentrations of folate.
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Protein Aliases: folate transporter 1; IFC-1; Intestinal folate carrier 1; intestinal folate carrier protein; Methotrexate carrier 1; methotrexate carrier 2; methotrexate carrier 5; methotrexate carrier 6; MTX-1; Plasma membrane folate antiporter SLC19A1; Reduced folate carrier 1; Reduced folate transporter; RFC-1; RFC1; solute carrier family 19 (sodium/hydrogen exchanger), member 1; Solute carrier family 19 member 1; solute carrier family 19, member 1
Gene Aliases: AI323572; MTX1; RFC; RFC-1; RFC1; Slc19a1
UniProt ID: (Mouse) P41438, (Rat) Q62866
Entrez Gene ID: (Mouse) 20509, (Rat) 29723
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