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Product Details
PA5-57508
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SLC26A3. Recombinant protein control fragment (Product #RP-89305).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2647427
Product Specific Information
Immunogen sequence: DQPINTTDLP FHIDWNDDLP LNIEVPKISL HSLILDFSAV SFLDVSSVRG LKSILQEFIR IKVDVYIVGT DDDFIEKLNR YEFFDGEVKS SIFFLTIHDA VLHILMKKDY STSKFNP
Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 85%.
Target Information
SLC26A3 is a chloride/bicarbonate exchanger that is involved in absorption inside the colon. SLC26A3 helps mediate electrolyte and fluid absorption. The protein encoded by the SLC26A3 gene is a transmembrane glycoprotein that functions as a sulfate transporter, and it is localized to the mucosa. The chloride ions transported by SLC26A3 cross the cell membrane in exchange for biocarbonate ions. SLC26A3 is localized in the mucosa of the lower intestinal tract, specifically the apical membrane of the columnar epithelium and in some goblet cells. Diseases associated with SLC26A3 protein dysfunction include congenital chloride diarrhea and congenital secretory chloride diarrhea 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Chloride anion exchanger; Down-regulated in adenoma; down-regulated in adenoma protein; Protein DRA; solute carrier family 26 (anion exchanger), member 3; Solute carrier family 26 member 3; solute carrier family 26, member 3
Gene Aliases: CLD; DRA; SLC26A3
UniProt ID: (Human) P40879
Entrez Gene ID: (Human) 1811
transcription factor activity, sequence-specific DNA binding
transcription cofactor activity
transporter activity
chloride channel activity
inorganic anion exchanger activity
protein binding
secondary active sulfate transmembrane transporter activity
bicarbonate transmembrane transporter activity
chloride transmembrane transporter activity
sulfate transmembrane transporter activity
anion:anion antiporter activity
oxalate transmembrane transporter activity
transporter
regulation of transcription, DNA-templated
ion transport
anion transport
excretion
bicarbonate transport
oxalate transport
regulation of membrane potential
sperm capacitation
regulation of intracellular pH
intracellular pH elevation
membrane hyperpolarization
cellular response to cAMP
sulfate transmembrane transport
chloride transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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